Developing a new paradigm for thymus organogenesis

Immunobiology: the immune system in health and disease

1995 • 3,893 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

Hox genes in vertebrate development

1994 • 2,057 citations

IMMUNOBIOLOGY : the immunesystem in health and disease

2001 • 1,685 citations

IMMUNOLOGICAL FUNCTION OF THE THYMUS

1961 • 1,359 citations

Fate of the mammalian cardiac neural crest

2000 • 1,123 citations

Induction of T Cell Development from Hematopoietic Progenitor Cells by Delta-like-1 In Vitro

2002 • 1,095 citations

An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination

1998 • 1,048 citations

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

2001 • 1,043 citations

Mesenchymal derivatives of the neural crest: analysis of chimaeric quail and chick embryos

1975 • 966 citations

Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5

1991 • 856 citations

‘Nude’, a new hairless gene with pleiotropic effects in the mouse

1966 • 834 citations

Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities

1998 • 817 citations

The PDGFα receptor is required for neural crest cell development and for normal patterning of the somites

1997 • 706 citations

Absence of Thymus in a Mouse Mutant

1968 • 701 citations

The roles of FGFs in the early development of vertebrate limbs

1998 • 659 citations

New member of the winged-helix protein family disrupted in mouse and rat nude mutations

1994 • 651 citations

Selective Defects in the Development of the Fetal and Adult Lymphoid System in Mice with an Ikaros Null Mutation

1996 • 619 citations

The Eye-Specification Proteins So and Eya Form a Complex and Regulate Multiple Steps in Drosophila Eye Development

1997 • 587 citations

Developmental Biology

2023 • 522 citations

Dependence of Thymus Development on Derivatives of the Neural Crest

1984 • 463 citations

Lymphostromal interactions in thymic development and function

2001 • 461 citations

The thymic microenvironment

1993 • 459 citations

Two Genetically Separable Steps in the Differentiation of Thymic Epithelium

1996 • 447 citations

The role of Hoxa-3 in mouse thymus and thyroid development

1995 • 421 citations

Tracing of cells of the avian thymus through embryonic life in interspecific chimeras.

1975 • 409 citations

Genetic ablation of parathyroid glands reveals another source of parathyroid hormone

2000 • 400 citations

Mapping Precursor Movement through the Postnatal Thymus Reveals Specific Microenvironments Supporting Defined Stages of Early Lymphoid Development

2001 • 394 citations

Thymic Medullary Epithelial Cell Differentiation, Thymocyte Emigration, and the Control of Autoimmunity Require Lympho–Epithelial Cross Talk via LTβR

2003 • 361 citations

AnFgf8mouse mutant phenocopies human 22q11 deletion syndrome

2002 • 359 citations

Morphogenetic interactions in the development of the mouse thymus gland

1960 • 336 citations

It takes two to tango

2003 • 335 citations

The Immune System

2000 • 313 citations

Pax3 is required for cardiac neural crest migration in the mouse: evidence from the splotch (Sp 2H) mutant

1997 • 313 citations

Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes

1995 • 295 citations

Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment

1998 • 292 citations

Generation of a complete thymic microenvironment by MTS24+ thymic epithelial cells

2002 • 290 citations

HoxGroup 3 Paralogs Regulate the Development and Migration of the Thymus, Thyroid, and Parathyroid Glands

1998 • 286 citations

Development in the thymus: it takes two to tango

1993 • 281 citations

Eya1is required for the morphogenesis of mammalian thymus, parathyroid and thyroid

2002 • 270 citations

Identification and Characterization of Thymic Epithelial Progenitor Cells

2002 • 269 citations

Development of thymus, parathyroids, and ultimo‐branchial bodies in NMRI and nude mice

1980 • 264 citations

Transplantation of Thymus Tissue in Complete DiGeorge Syndrome

1999 • 256 citations

Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice

2002 • 254 citations

Development of the Thymus Requires Signaling Through the Fibroblast Growth Factor Receptor R2-IIIb

2001 • 241 citations

Gcm2 and Foxn1 mark early parathyroid- and thymus-specific domains in the developing third pharyngeal pouch

2001 • 237 citations

A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers of the human CD3E gene.

1994 • 233 citations

Critical Role for CXCR4 Signaling in Progenitor Localization and T Cell Differentiation in the Postnatal Thymus

2003 • 229 citations

Pax1 is expressed during development of the thymus epithelium and is required for normal T-cell maturation

1996 • 228 citations

The nu gene acts cell-autonomously and is required for differentiation of thymic epithelial progenitors.

1996 • 225 citations

Migration of cardiac neural crest cells in Splotch embryos

2000 • 221 citations

Stepwise development of thymic microenvironments in vivo is regulated by thymocyte subsets

2000 • 219 citations

Thymus, kidney and craniofacial abnormalities in Six1 deficient mice

2003 • 219 citations

Thymus medulla consisting of epithelial islets each derived from a single progenitor

2001 • 211 citations

Functional evidence for a single endodermal origin for the thymic epithelium

2004 • 209 citations

Isolation and characterization of mammalian homologs of the Drosophila gene glial cells missing

1998 • 201 citations

Promiscuous gene expression and central T-cell tolerance: more than meets the eye

2002 • 198 citations

Thymic epithelial cells provide unique signals for positive selection of CD4+CD8+ thymocytes in vitro.

1994 • 197 citations

Cutting Edge: Thymocyte-Independent and Thymocyte-Dependent Phases of Epithelial Patterning in the Fetal Thymus

2002 • 195 citations

Dissecting NK cell development using a novel alymphoid mouse model: investigating the role of the c-abl proto-oncogene in murine NK cell differentiation.

1999 • 186 citations

Cell migration and the control of post-natal T-cell lymphopoiesis in the thymus

2003 • 186 citations

Persistent truncus arteriosus in the Splotch mutant mouse

1989 • 184 citations

Dissecting NK Cell Development Using a Novel Alymphoid Mouse Model: Investigating the Role of the c-abl Proto-Oncogene in Murine NK Cell Differentiation

1999 • 163 citations

Thymus organogenesis and molecular mechanisms of thymic epithelial cell differentiation

2000 • 162 citations

Epithelial/mesenchymal interactions and branching morphogenesis of the lung

1998 • 156 citations

Differential Requirement for Mesenchyme in the Proliferation and Maturation of Thymic Epithelial Progenitors

2003 • 153 citations

Efficient generation of human T cells from a tissue-engineered thymic organoid

2000 • 152 citations

A domain of Foxn1 required for crosstalk-dependent thymic epithelial cell differentiation

2003 • 151 citations

Hoxa3 and Pax1 Regulate Epithelial Cell Death and Proliferation during Thymus and Parathyroid Organogenesis

2001 • 151 citations

Restriction specificities, alloreactivity, and allotolerance expressed by T cells from nude mice reconstituted with H-2-compatible or -incompatible thymus grafts.

1980 • 139 citations

Two distinct steps of immigration of hematopoietic progenitors into the early thymus anlage

2001 • 135 citations

Growth of Human Tumor Xenografts Implanted under the Renal Capsule of Normal Immunocompetent Mice

1979 • 133 citations

BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis

2003 • 124 citations

Medullary Thymic Epithelium: A Mosaic of Epithelial “Self”?

1998 • 114 citations

Organization of thymic medullary epithelial heterogeneity: implications for mechanisms of epithelial differentiation

2002 • 111 citations

Stromal cell types in the developing thymus of the normal and nude mouse embryo

1985 • 108 citations

The phenotypic heterogeneity of mouse thymic stromal cells.

1990 • 104 citations

Microenvironmental regulation of T cell development in the thymus

2000 • 102 citations

Role of thymic organ structure and stromal composition in steady‐state postnatal T‐cell production

2002 • 99 citations

Thymic epithelial cells provide Wnt signals to developing thymocytes

2003 • 91 citations

A developmental look at thymus organogenesis: where do the non-hematopoietic cells in the thymus come from?

2003 • 89 citations

Thymopoiesis requiresPax9 function in thymic epithelial cells

2002 • 85 citations

Tolerance induction by ‘megadose’ transplants of CD34+ stem cells: a new option for leukemia patients without an HLA-matched donor

2000 • 75 citations

In vitromodels of T cell development

1999 • 73 citations

One for all and all for one: thymic epithelial stem cells and regeneration

2002 • 72 citations

Nude Mouse Embryo: Ectodermal Nature of the Primordial Thymic Defect

1975 • 72 citations

Stem cell escalation enables HLA-disparate haematopoietic transplants in leukaemia patients

1999 • 62 citations

Thymic vasculature: organizer of the medullary epithelial compartment?

2000 • 61 citations

Cell migration and the anatomic control of thymocyte precursor differentiation

2000 • 59 citations

Role of the Nude Gene in Epithelial Terminal Differentiation

2002 • 55 citations

Early events in T lymphocyte genesis in the fetal thymus

1984 • 53 citations

Cloning and Characterization of Ehox, a Novel Homeobox Gene Essential for Embryonic Stem Cell Differentiation

2002 • 51 citations

Immuno-electron microscopy of the thymic epithelial microenvironment

1997 • 48 citations

Reconstitution of thymic function after stem cell transplantation in humans

2002 • 47 citations

Aortic arch and pharyngeal phenotype in the absence of BMP-dependent neural crest in the mouse

2002 • 43 citations

Characterization of stromal cell populations in the developing thymus of normal and nude mice

1984 • 35 citations

A Mouse Carrying Genetic Defect in the Choice Between T and B Lymphocytes

1998 • 30 citations

New serum‐free in vitro culture technique for midgestation mouse embryos

2003 • 30 citations

Expression of a novel homeobox gene Ehox in trophoblast stem cells and pharyngeal pouch endoderm

2003 • 22 citations

Effect of murine thymic epithelial cell line (MTEC1) on the functional expression of CD4+CD8– thymocyte subgroups

2000 • 19 citations

Neural crest function in thymus development.

1989 • 12 citations

Thymus Epithelial Cell Reaggregate Grafts

2000 • 11 citations