Effect of murine thymic epithelial cell line (MTEC1) on the functional expression of CD4+CD8– thymocyte subgroups

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

Two types of mouse helper T-cell clone

1987 • 813 citations

Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production.

1991 • 705 citations

Activation events during thymic selection.

1992 • 326 citations

Negative Selection in the Thymus Includes Semimature T Cells

1997 • 224 citations

Th1 and Th2 cells

2001 • 217 citations

Quantitative Impact of Thymic Clonal Deletion on the T Cell Repertoire

1997 • 198 citations

Thymic emigration: conveyor belts or lucky dips?

1995 • 186 citations

CD28 is an inducible T cell surface antigen that transduces a proliferative signal in CD3+ mature thymocytes.

1990 • 173 citations

CD4+ and CD8+ T cells acquire specific lymphokine secretion potentials during thymic maturation

1991 • 155 citations

The majority of CD4+8- thymocytes are functionally immature.

1991 • 137 citations

Murine CD4+ T cell subsets defined.

1988 • 102 citations

Natural and Engineered Disorders of Lymphocyte Development

1998 • 102 citations

A Molecular Map of T Cell Development

1998 • 94 citations

Development, organization and function of the thymic medulla in normal, immunodeficient or autoimmune mice

1999 • 84 citations

Thymic cortical epithelium is sufficient for the development of mature T cells in relB-deficient mice.

1997 • 83 citations

Downregulation of CD1 Marks Acquisition of Functional Maturation of Human Thymocytes and Defines a Control Point in Late Stages of Human T Cell Development

1997 • 77 citations

Subpopulations of mature murine thymocytes: Properties of CD4−CD8+ and CD4+CD8− thymocytes lacking the heat-stable antigen

1988 • 58 citations

The majority of postselection CD4+ single-positive thymocytes requires the thymus to produce long-lived, functional T cells.

1995 • 55 citations

Timing and Casting for Actors of Thymic Negative Selection

1999 • 39 citations

Murine CD4⁺ T‐Cell Subsets

1991 • 38 citations

Differentiation to T helper cells in the thymus. Gradual acquisition of T helper cell function by CD3+CD4+ cells.

1995 • 35 citations

CD4+8- and CD4-8+ mature thymocytes require different post-selection processing for final development.

1993 • 34 citations

Phenotypic identification of the subgroups of murine T‐cell receptor αβ⁺ CD4⁺ CD8⁻ thymocytes and its implication in the late stage of thymocyte development

1999 • 31 citations

Intrathymic T cell receptor (TcR) targeting in mice lacking CD4 or major histocompatibility complex (MHC) class II: Rescue of CD4 T cell lineage without co‐engagement of TcR/CD4 by MHC class II

1995 • 19 citations

MTS-32 monoclonal antibody defines CD4+8- thymocyte subsets that differ in their maturation level, lymphokine secretion, and selection patterns.

1994 • 17 citations

Multiple types of cytokines constitutively produced by an established murine thymic epithelial cell line.

1992 • 14 citations

Functional maturation of mouse CD4+CD8- thymocytes induced by medullary-type thymus epithelial cells.

1996 • 6 citations