Mechanisms and functions of eph and ephrin signalling

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Lipid rafts and signal transduction

2000 • 6,079 citations

Functional organization of the yeast proteome by systematic analysis of protein complexes

2002 • 4,751 citations

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

2002 • 3,624 citations

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

1997 • 2,268 citations

Molecular Distinction and Angiogenic Interaction between Embryonic Arteries and Veins Revealed by ephrin-B2 and Its Receptor Eph-B4

1998 • 1,663 citations

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

2000 • 1,398 citations

THE EPHRINS AND EPH RECEPTORS IN NEURAL DEVELOPMENT

1998 • 1,082 citations

Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis

1999 • 1,019 citations

RHO GTPASES in neuronal morphogenesis

2000 • 982 citations

Ligands for EPH-Related Receptor Tyrosine Kinases that Require Membrane Attachment or Clustering for Activity

1994 • 720 citations

Symmetrical Mutant Phenotypes of the Receptor EphB4 and Its Specific Transmembrane Ligand ephrin-B2 in Cardiovascular Development

1999 • 708 citations

EphB Receptors Interact with NMDA Receptors and Regulate Excitatory Synapse Formation

2000 • 702 citations

Rho Family GTPases and Neuronal Growth Cone Remodelling: Relationship between Increased Complexity Induced by Cdc42Hs, Rac1, and Acetylcholine and Collapse Induced by RhoA and Lysophosphatidic Acid

1997 • 601 citations

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos

1993 • 555 citations

Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor Induce Expression of CXCR4 on Human Endothelial Cells

1999 • 545 citations

Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation

1999 • 542 citations

EphA Receptors Regulate Growth Cone Dynamics through the Novel Guanine Nucleotide Exchange Factor Ephexin

2001 • 537 citations

Nuk Controls Pathfinding of Commissural Axons in the Mammalian Central Nervous System

1996 • 536 citations

Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands

1996 • 526 citations

Structure, development, and plasticity of dendritic spines

1999 • 511 citations

Integrin signalling and tyrosine phosphorylation: just the FAKs?

1998 • 502 citations

Eph Family Transmembrane Ligands Can Mediate Repulsive Guidance of Trunk Neural Crest Migration and Motor Axon Outgrowth

1997 • 477 citations

Eph receptors and ephrins restrict cell intermingling and communication

1999 • 469 citations

PDZ Proteins Bind, Cluster, and Synaptically Colocalize with Eph Receptors and Their Ephrin Ligands

1998 • 455 citations

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

1993 • 451 citations

In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrins

1999 • 431 citations

Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses

1998 • 423 citations

c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF

1999 • 420 citations

Chemokine Receptors in Human Endothelial Cells

1998 • 407 citations

Essential Roles for the Abl and Arg Tyrosine Kinases in Neurulation

1998 • 403 citations

Tyrosine Phosphorylation of Transmembrane Ligands for Eph Receptors

1997 • 394 citations

Ephrin-A5 Induces Collapse of Growth Cones by Activating Rho and Rho Kinase

2000 • 393 citations

Interactions of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration

1997 • 389 citations

Ephrin-B Reverse Signaling Is Mediated by a Novel PDZ-RGS Protein and Selectively Inhibits G Protein–Coupled Chemoattraction

2001 • 382 citations

The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization

2000 • 379 citations

Ephrin-B2 Selectively Marks Arterial Vessels and Neovascularization Sites in the Adult, with Expression in Both Endothelial and Smooth-Muscle Cells

2001 • 362 citations

Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway

2001 • 348 citations

Structural Basis for Autoinhibition of the EphB2 Receptor Tyrosine Kinase by the Unphosphorylated Juxtamembrane Region

2001 • 346 citations

EphrinB Ligands Recruit GRIP Family PDZ Adaptor Proteins into Raft Membrane Microdomains

1999 • 345 citations

Regulation of repulsion versus adhesion by different splice forms of an Eph receptor

2000 • 344 citations

The EphA4 and EphB1 receptor tyrosine kinases and ephrin-B2 ligand regulate targeted migration of branchial neural crest cells

1997 • 343 citations

Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation.

1996 • 334 citations

Eph receptors and ephrins in neural development

1999 • 330 citations

Crystal structure of an Eph receptor–ephrin complex

2001 • 330 citations

Cycling, stressed-out and nervous: cellular functions of c-Abl

1999 • 324 citations

The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals

2001 • 320 citations

The Receptor Tyrosine Kinase EphB2 Regulates NMDA-Dependent Synaptic Function

2001 • 309 citations

Kinase-Independent Requirement of EphB2 Receptors in Hippocampal Synaptic Plasticity

2001 • 307 citations

EphB/Syndecan-2 Signaling in Dendritic Spine Morphogenesis

2001 • 303 citations

EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract

1998 • 301 citations

EphrinB Phosphorylation and Reverse Signaling

2002 • 294 citations

Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion

1999 • 294 citations

Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells

1997 • 276 citations

Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity.

1995 • 273 citations

The Cytoplasmic Domain of the Ligand EphrinB2 Is Required for Vascular Morphogenesis but Not Cranial Neural Crest Migration

2001 • 264 citations

Kinase-Dependent and Kinase-Independent Functions of EphA4 Receptors in Major Axon Tract Formation In Vivo

2001 • 257 citations

The VAB-1 Eph Receptor Tyrosine Kinase Functions in Neural and Epithelial Morphogenesis in C. elegans

1998 • 254 citations

Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity.

1995 • 251 citations

Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control

2001 • 251 citations

The Carboxyl Terminus of B Class Ephrins Constitutes a PDZ Domain Binding Motif

1999 • 244 citations

Oligomeric Structure of the Human EphB2 Receptor SAM Domain

1999 • 233 citations

The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization.

1999 • 233 citations

Ephrin-A5 modulates cell adhesion and morphology in an integrin-dependent manner

2000 • 227 citations

Forward Signaling Mediated by Ephrin-B3 Prevents Contralateral Corticospinal Axons from Recrossing the Spinal Cord Midline

2001 • 218 citations

Eph receptors and ephrins: Regulators of guidance and assembly

2000 • 217 citations

EphB2 Guides Axons at the Midline and Is Necessary for Normal Vestibular Function

2000 • 210 citations

Phosphorylation of Tyrosine Residues in the Kinase Domain and Juxtamembrane Region Regulates the Biological and Catalytic Activities of Eph Receptors

2000 • 207 citations

Surface densities of ephrin-B1 determine EphB1-coupled activation of cell attachment through alpha vbeta 3 and alpha 5beta 1 integrins

1999 • 202 citations

PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor

1998 • 202 citations

An Eph receptor regulates integrin activity through R-Ras

1999 • 195 citations

The Junction-associated Protein AF-6 Interacts and Clusters with Specific Eph Receptor Tyrosine Kinases at Specialized Sites of Cell–Cell Contact in the Brain

1999 • 195 citations

Kinase independent function of EphB receptors in retinal axon pathfinding to the optic disc from dorsal but not ventral retina

2000 • 191 citations

Downregulation of the Ras–Mitogen-Activated Protein Kinase Pathway by the EphB2 Receptor Tyrosine Kinase Is Required for Ephrin-Induced Neurite Retraction

2001 • 187 citations

The Ephrin VAB-2/EFN-1 Functions in Neuronal Signaling to Regulate Epidermal Morphogenesis in C. elegans

1999 • 180 citations

An ephrin-A-dependent Signaling Pathway Controls Integrin Function and Is Linked to the Tyrosine Phosphorylation of a 120-kDa Protein

2001 • 175 citations

Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity.

1994 • 151 citations

Nck Recruitment to Eph Receptor, EphB1/ELK, Couples Ligand Activation to c-Jun Kinase

1998 • 151 citations

Signaling by Eph receptors and their ephrin ligands

1998 • 147 citations

A role for the EphA family in the topographic targeting of vomeronasal axons

2001 • 146 citations

Ligand Activation of ELK Receptor Tyrosine Kinase Promotes Its Association with Grb10 and Grb2 in Vascular Endothelial Cells

1996 • 145 citations

Membrane-bound LERK2 ligand can signal through three different Eph-related receptor tyrosine kinases.

1995 • 141 citations

Nck-Interacting Ste20 Kinase Couples Eph Receptors to c-Jun N-Terminal Kinase and Integrin Activation

2000 • 132 citations

Characterization of a Novel Src-like Adapter Protein That Associates with the Eck Receptor Tyrosine Kinase

1995 • 127 citations

Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region

1998 • 123 citations

Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses

2000 • 122 citations

Multiple Ephrins Control Cell Organization in C. elegans Using Kinase-Dependent and -Independent Functions of the VAB-1 Eph Receptor

1999 • 120 citations

A Role for CAP, a Novel, Multifunctional Src Homology 3 Domain-containing Protein in Formation of Actin Stress Fibers and Focal Adhesions

1998 • 116 citations

A Novel Signaling Intermediate, SHEP1, Directly Couples Eph Receptors to R-Ras and Rap1A

1999 • 116 citations

Crystal structure of the ligand-binding domain of the receptor tyrosine kinase EphB2

1998 • 114 citations

Full Activation of the Platelet-derived Growth Factor β-Receptor Kinase Involves Multiple Events

1998 • 113 citations

Five novel avian Eph-related tyrosine kinases are differentially expressed.

1993 • 112 citations

Dendritic spines shaped by synaptic activity

2000 • 109 citations

A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn.

1996 • 109 citations

Crystal Structure of an Ephrin Ectodomain

2001 • 106 citations

Cell-type specific and estrogen dependent expression of the receptor tyrosine kinase EphB4 and its ligand ephrin-B2 during mammary gland morphogenesis

1998 • 105 citations

Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor

2001 • 100 citations

The EphA8 Receptor Regulates Integrin Activity through p110γ Phosphatidylinositol-3 Kinase in a Tyrosine Kinase Activity-Independent Manner

2001 • 95 citations

Immunolocalization of the receptor tyrosine kinase EphA4 in the adult rat central nervous system

1997 • 89 citations

Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons

2002 • 85 citations

Fibroblast Growth Factor Receptor-Mediated Rescue of x-Ephrin B1-Induced Cell Dissociation in XenopusEmbryos

2000 • 83 citations

Multiple in Vivo Tyrosine Phosphorylation Sites in EphB Receptors

1999 • 82 citations

In Vivo Tyrosine Phosphorylation Sites of Activated Ephrin-B1 and EphB2 from Neural Tissue

2001 • 81 citations

The N-terminal globular domain of Eph receptors is sufficient for ligand binding and receptor signaling

1997 • 80 citations

Solution structure of the receptor tyrosine kinase EphB2 SAM domain and identification of two distinct homotypic interaction sites

1999 • 77 citations

Retinal axon growth cones respond to EphB extracellular domains as inhibitory axon guidance cues

2001 • 77 citations

Signal transfer by Eph receptors

1999 • 71 citations

Isolation and Characterization of Dek, a Drosophila Eph Receptor Protein Tyrosine Kinase

1999 • 60 citations

Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions

1998 • 56 citations

Biological and biochemical activities of a chimeric epidermal growth factor-Elk receptor tyrosine kinase.

1993 • 55 citations

Neural development: Bidirectional signals establish boundaries

1999 • 38 citations

Characterization of Grb4, an adapter protein interacting with Bcr-Abl

2000 • 27 citations

Functional activation of EphA5 receptor does not promote cell proliferation in the aberrant EphA5 expressing human glioblastoma U-118 MG cell line

1999 • 23 citations