Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation

Integrins: A family of cell surface receptors

1987 • 4,322 citations

Cell Migration: A Physically Integrated Molecular Process

1996 • 3,909 citations

Molecular Distinction and Angiogenic Interaction between Embryonic Arteries and Veins Revealed by ephrin-B2 and Its Receptor Eph-B4

1998 • 1,663 citations

Integrins: Emerging Paradigms of Signal Transduction

1995 • 1,591 citations

Tyrosine Phosphorylation of Focal Adhesion Kinase at Sites in the Catalytic Domain Regulates Kinase Activity: a Role for Src Family Kinases

1995 • 989 citations

Eph Receptors and Ligands Comprise Two Major Specificity Subclasses and Are Reciprocally Compartmentalized during Embryogenesis

1996 • 851 citations

In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases

1995 • 849 citations

Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

1992 • 831 citations

Protein tyrosine phosphatases in signal transduction

1997 • 766 citations

Ligands for EPH-Related Receptor Tyrosine Kinases that Require Membrane Attachment or Clustering for Activity

1994 • 720 citations

Integrin cytoplasmic domains mediate inside-out signal transduction

1994 • 682 citations

Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains.

1995 • 620 citations

Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn

1996 • 595 citations

pp125^FAK-Dependent Tyrosine Phosphorylation of Paxillin Creates a High-Affinity Binding Site for Crk

1995 • 534 citations

From Form to Function: Signaling by Protein Tyrosine Phosphatases

1996 • 526 citations

Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation.

1996 • 514 citations

Integrin signalling and tyrosine phosphorylation: just the FAKs?

1998 • 502 citations

A mechanism for regulation of the adhesion-associated protein tyrosine kinase pp125FAK

1996 • 488 citations

Eph Family Transmembrane Ligands Can Mediate Repulsive Guidance of Trunk Neural Crest Migration and Motor Axon Outgrowth

1997 • 477 citations

Eph receptors and ephrins restrict cell intermingling and communication

1999 • 469 citations

PDZ Proteins Bind, Cluster, and Synaptically Colocalize with Eph Receptors and Their Ephrin Ligands

1998 • 455 citations

Regulation of the fibronectin receptor affinity by divalent cations.

1988 • 441 citations

In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrins

1999 • 431 citations

Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses

1998 • 423 citations

L1-mediated axon outgrowth occurs via a homophilic binding mechanism

1989 • 423 citations

Interactions of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration

1997 • 389 citations

The EphA4 and EphB1 receptor tyrosine kinases and ephrin-B2 ligand regulate targeted migration of branchial neural crest cells

1997 • 343 citations

Inhibition of Cell Spreading by Expression of the C-Terminal Domain of Focal Adhesion Kinase (FAK) Is Rescued by Coexpression of Src or Catalytically Inactive FAK: a Role for Paxillin Tyrosine Phosphorylation

1997 • 329 citations

Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells

1997 • 276 citations

Signal transduction through integrins: A central role for focal adhesion kinase?

1995 • 273 citations

Affinity modulation of integrin alpha 5 beta 1: regulation of the functional response by soluble fibronectin.

1993 • 240 citations

cDNA Cloning and Characterization of eck, an Epithelial Cell Receptor Protein-Tyrosine Kinase in the eph/elk Family of Protein Kinases

1990 • 234 citations

Distinct and Overlapping Expression Patterns of Ligands for Eph-Related Receptor Tyrosine Kinases during Mouse Embryogenesis

1996 • 215 citations

Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells.

1994 • 214 citations

Surface densities of ephrin-B1 determine EphB1-coupled activation of cell attachment through alpha vbeta 3 and alpha 5beta 1 integrins

1999 • 202 citations

PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor

1998 • 202 citations

cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases.

1990 • 159 citations

Thyroid Hormone Modulates the Interaction between Iron Regulatory Proteins and the Ferritin mRNA Iron-responsive Element

1996 • 154 citations

Ephrins and their receptors: a repulsive topic?

1997 • 154 citations

Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity.

1994 • 151 citations

Ligand Activation of ELK Receptor Tyrosine Kinase Promotes Its Association with Grb10 and Grb2 in Vascular Endothelial Cells

1996 • 145 citations

Adhesion of T and B lymphocytes to extracellular matrix and endothelial cells can be regulated through the beta subunit of VLA

1992 • 139 citations

Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region

1998 • 123 citations

AL‐1‐induced Growth Cone Collapse of Rat Cortical Neurons is Correlated with REK7 Expression and Rearrangement of the Actin Cytoskeleton

1997 • 103 citations

Cell Signalling: Receptor orphans find a family

1995 • 82 citations

Focal Adhesion and Stress Fiber Formation Is Regulated by Tyrosine Phosphatase Activity

1996 • 81 citations

p125FAK Tyrosine Phosphorylation and Focal Adhesion Assembly: Studies with Phosphotyrosine Phosphatase Inhibitors

1995 • 71 citations

Low Molecular Weight Protein-tyrosine Phosphatase Tyrosine Phosphorylation by c-Src during Platelet-derived Growth Factor-induced Mitogenesis Correlates with Its Subcellular Targeting

1998 • 54 citations

Identification of the Major SHPTP2-binding Protein That Is Tyrosine-phosphorylated in Response to Insulin

1995 • 48 citations

Lerk2 (Ephrin-B1) Is a Collapsing Factor for a Subset of Cortical Growth Cones and Acts by a Mechanism Different from AL-1 (Ephrin-A5)

1997 • 47 citations