Eph receptors and ephrins in neural development

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

The Molecular Biology of Axon Guidance

1996 • 3,246 citations

CHEMOAFFINITY IN THE ORDERLY GROWTH OF NERVE FIBER PATTERNS AND CONNECTIONS

1963 • 1,947 citations

Molecular Distinction and Angiogenic Interaction between Embryonic Arteries and Veins Revealed by ephrin-B2 and Its Receptor Eph-B4

1998 • 1,663 citations

Eph Receptors and Ligands Comprise Two Major Specificity Subclasses and Are Reciprocally Compartmentalized during Embryogenesis

1996 • 851 citations

In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases

1995 • 849 citations

Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection map

1995 • 740 citations

Ligands for EPH-Related Receptor Tyrosine Kinases that Require Membrane Attachment or Clustering for Activity

1994 • 720 citations

Segmentation in the chick embryo hindbrain is defined by cell lineage restrictions

1990 • 685 citations

The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons

1995 • 566 citations

Nuk Controls Pathfinding of Commissural Axons in the Mammalian Central Nervous System

1996 • 536 citations

Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands

1996 • 526 citations

Mechanisms and Molecules that Control Growth Cone Guidance

1996 • 515 citations

Eph Family Transmembrane Ligands Can Mediate Repulsive Guidance of Trunk Neural Crest Migration and Motor Axon Outgrowth

1997 • 477 citations

Ephrin-A5 (AL-1/RAGS) Is Essential for Proper Retinal Axon Guidance and Topographic Mapping in the Mammalian Visual System

1998 • 460 citations

Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses

1998 • 423 citations

Topographically Specific Effects of ELF-1 on Retinal Axon Guidance In Vitro and Retinal Axon Mapping In Vivo

1996 • 418 citations

Tyrosine Phosphorylation of Transmembrane Ligands for Eph Receptors

1997 • 394 citations

Interactions of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration

1997 • 389 citations

Role of B61, the Ligand for the Eck Receptor Tyrosine Kinase, in TNF-α-Induced Angiogenesis

1995 • 368 citations

Development of topographic order in the mammalian retinocollicular projection

1992 • 360 citations

The EphA4 and EphB1 receptor tyrosine kinases and ephrin-B2 ligand regulate targeted migration of branchial neural crest cells

1997 • 343 citations

Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation.

1996 • 334 citations

Expression of truncated Sek-1 receptor tyrosine kinase disrupts the segmental restriction of gene expression in the Xenopus and zebrafish hindbrain

1995 • 315 citations

Axon Guidance by Gradients of a Target-Derived Component

1992 • 312 citations

Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells

1997 • 276 citations

Eph signaling is required for segmentation and differentiation of the somites

1998 • 265 citations

Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation

1995 • 261 citations

The VAB-1 Eph Receptor Tyrosine Kinase Functions in Neural and Epithelial Morphogenesis in C. elegans

1998 • 254 citations

Shared and distinct functions of RAGS and ELF-1 in guiding retinal axons

1997 • 239 citations

B61 is a ligand for the ECK receptor protein-tyrosine kinase

1994 • 239 citations

Distinct and Overlapping Expression Patterns of Ligands for Eph-Related Receptor Tyrosine Kinases during Mouse Embryogenesis

1996 • 215 citations

Detection of Ligands in Regions Anatomically Connected to Neurons Expressing the Eph Receptor Bsk: Potential Roles in Neuron–Target Interaction

1996 • 159 citations

Ephrins and their receptors: a repulsive topic?

1997 • 154 citations

Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity.

1994 • 151 citations

Nck Recruitment to Eph Receptor, EphB1/ELK, Couples Ligand Activation to c-Jun Kinase

1998 • 151 citations

Graded and Lamina-Specific Distributions of Ligands of EphB Receptor Tyrosine Kinases in the Developing Retinotectal System

1997 • 150 citations

Expression and Tyrosine Phosphorylation of Eph Receptors Suggest Multiple Mechanisms in Patterning of the Visual System

1998 • 149 citations

Signaling by Eph receptors and their ephrin ligands

1998 • 147 citations

Regulation of topographic projection in the brain: Elf-1 in the hippocamposeptal system.

1996 • 147 citations

Ligand Activation of ELK Receptor Tyrosine Kinase Promotes Its Association with Grb10 and Grb2 in Vascular Endothelial Cells

1996 • 145 citations

Regulation of thalamic neurite outgrowth by the Eph ligand ephrin-A5: Implications in the development of thalamocortical projections

1998 • 145 citations

Adhesive Recognition and Retinotectal Specificity

1973 • 140 citations

Biochemical investigations of retinotectal adhesive specificity

1977 • 138 citations

Eph Family Receptors and Their Ligands Distribute in Opposing Gradients in the Developing Mouse Retina

1996 • 137 citations

Selective dispersal of avian rhombomere cells in orthotopic and heterotopic grafts

1993 • 135 citations

Dual Action of a Ligand for Eph Receptor Tyrosine Kinases on Specific Populations of Axons during the Development of Cortical Circuits

1998 • 129 citations

Two Eph receptor tyrosine kinase ligands control axon growth and may be involved in the creation of the retinotectal map in the zebrafish

1997 • 125 citations

Polarized Expression of the Receptor Protein Tyrosine Kinase Cek5 in the Developing Avian Visual System

1995 • 125 citations

Control of Topographic Retinal Axon Branching by Inhibitory Membrane-Bound Molecules

1994 • 122 citations

ELK and LERK-2 in developing kidney and microvascular endothelial assembly.

1996 • 114 citations

Segmental migration of trunk neural crest: time-lapse analysis reveals a role for PNA-binding molecules

1995 • 109 citations

A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn.

1996 • 109 citations

The receptor tyrosine kinase, Cek8, is transiently expressed on subtypes of motoneurons in the spinal cord during development

1996 • 105 citations

Responses of retinal axons in vivo and in vitro to position-encoding molecules in the embryonic superior colliculus

1992 • 104 citations

AL‐1‐induced Growth Cone Collapse of Rat Cortical Neurons is Correlated with REK7 Expression and Rearrangement of the Actin Cytoskeleton

1997 • 103 citations

Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors

1997 • 101 citations

Reciprocal Expression of the Eph Receptor Cek5 and Its Ligand(s) in the Early Retina

1997 • 97 citations

Tyrosine phosphorylation of L1 family adhesion molecules: Implication of the Eph kinase Cek5

1997 • 94 citations

Segregation of Rhombomeres by Differential Chemoaffinity

1997 • 90 citations

Expression of theTyro4/Mek4/Cek4Gene Specifically Marks a Subset of Embryonic Motor Neurons and Their Muscle Targets

1996 • 84 citations

The Eph Kinase Ligand AL-1 Is Expressed by Rostral Muscles and Inhibits Outgrowth from Caudal Neurons

1996 • 84 citations

Loss of cell adhesion in Xenopus laevis embryos mediated by the cytoplasmic domain of XLerk, an erythropoietin-producing hepatocellular ligand

1998 • 81 citations

Adhesive recognition between developing retinal cells and the optic tecta of the chick embryo

1975 • 80 citations

Disruption of Cell Adhesion inXenopusEmbryos by Pagliaccio, an Eph-Class Receptor Tyrosine Kinase

1996 • 76 citations

Expression Pattern of Collagen IX and Potential Role in the Segmentation of the Peripheral Nervous System

1996 • 76 citations

Cellular morphology and extracellular space at rhombomere boundaries in the chick embryo hindbrain

1993 • 72 citations

Similarities and Differences in the Way Transmembrane-Type Ligands Interact with the Elk Subclass of Eph Receptors

1996 • 68 citations

Eph receptor–ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro

1998 • 62 citations

Target-independent diversification and target-specific projection of chemically defined retinal ganglion cell subsets

1995 • 57 citations

The inhibitory effect on neurite outgrowth of motoneurons exerted by the ligands ELF-1 and RAGS

1997 • 40 citations

Novel Expression Gradients of Eph-like Receptor Tyrosine Kinases in the Developing Chick Retina

1997 • 33 citations

Expression of an amphibian homolog of the Eph family of receptor tyrosine kinases is developmentally regulated.

1995 • 28 citations