Symmetrical Mutant Phenotypes of the Receptor EphB4 and Its Specific Transmembrane Ligand ephrin-B2 in Cardiovascular Development

Mechanisms of angiogenesis

1997 • 5,696 citations

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

1996 • 2,844 citations

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1995 • 2,650 citations

Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

1996 • 1,969 citations

Visualizing an Olfactory Sensory Map

1996 • 1,969 citations

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

1995 • 1,808 citations

Molecular Distinction and Angiogenic Interaction between Embryonic Arteries and Veins Revealed by ephrin-B2 and Its Receptor Eph-B4

1998 • 1,663 citations

Vasculogenesis

1995 • 1,344 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

Blood Vessel Formation: What Is Its Molecular Basis?

1996 • 1,242 citations

A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF

1998 • 1,239 citations

Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate.

1994 • 1,032 citations

Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis

1999 • 1,019 citations

Eph Receptors and Ligands Comprise Two Major Specificity Subclasses and Are Reciprocally Compartmentalized during Embryogenesis

1996 • 851 citations

In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases

1995 • 849 citations

Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, Angiopoietins, and ephrins in vascular development

1999 • 795 citations

PDGF, TGF-β, and Heterotypic Cell–Cell Interactions Mediate Endothelial Cell–induced Recruitment of 10T1/2 Cells and Their Differentiation to a Smooth Muscle Fate

1998 • 789 citations

neurogenin1 Is Essential for the Determination of Neuronal Precursors for Proximal Cranial Sensory Ganglia

1998 • 731 citations

Induction of Neoangiogenesis in Ischemic Myocardium by Human Growth Factors

1998 • 541 citations

Nuk Controls Pathfinding of Commissural Axons in the Mammalian Central Nervous System

1996 • 536 citations

Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands

1996 • 526 citations

Eph Family Transmembrane Ligands Can Mediate Repulsive Guidance of Trunk Neural Crest Migration and Motor Axon Outgrowth

1997 • 477 citations

Eph receptors and ephrins restrict cell intermingling and communication

1999 • 469 citations

Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate

1998 • 455 citations

In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrins

1999 • 431 citations

Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses

1998 • 423 citations

Topographically Specific Effects of ELF-1 on Retinal Axon Guidance In Vitro and Retinal Axon Mapping In Vivo

1996 • 418 citations

Tyrosine Phosphorylation of Transmembrane Ligands for Eph Receptors

1997 • 394 citations

Interactions of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration

1997 • 389 citations

Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2

1998 • 376 citations

Role of B61, the Ligand for the Eck Receptor Tyrosine Kinase, in TNF-α-Induced Angiogenesis

1995 • 368 citations

The EphA4 and EphB1 receptor tyrosine kinases and ephrin-B2 ligand regulate targeted migration of branchial neural crest cells

1997 • 343 citations

Antiangiogenic gene therapy

1998 • 201 citations

ELF-2, a New Member of the Eph Ligand Family, Is Segmentally Expressed in Mouse Embryos in the Region of the Hindbrain and Newly Forming Somites

1995 • 155 citations

Membrane-bound LERK2 ligand can signal through three different Eph-related receptor tyrosine kinases.

1995 • 141 citations

Molecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase Htk.

1995 • 101 citations

Characterization of a ligand for receptor protein-tyrosine kinase HTK expressed in immature hematopoietic cells.

1996 • 89 citations