THE EPHRINS AND EPH RECEPTORS IN NEURAL DEVELOPMENT

The Molecular Biology of Axon Guidance

1996 • 3,246 citations

Epidermal Growth Factor

1979 • 2,964 citations

CD44 is the principal cell surface receptor for hyaluronate

1990 • 2,433 citations

CHEMOAFFINITY IN THE ORDERLY GROWTH OF NERVE FIBER PATTERNS AND CONNECTIONS

1963 • 1,947 citations

Physiology of the Neurotrophins

1996 • 1,908 citations

Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains

1997 • 1,371 citations

The origin of pattern and polarity in the Drosophila embryo

1992 • 1,367 citations

Receptor Protein-Tyrosine Kinases and Their Signal Transduction Pathways

1994 • 1,309 citations

[2] Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members

1991 • 1,225 citations

Patterning the Vertebrate Neuraxis

1996 • 1,151 citations

Collapsin: A protein in brain that induces the collapse and paralysis of neuronal growth cones

1993 • 1,146 citations

Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in xenopus embryos

1991 • 1,103 citations

Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes

1994 • 1,005 citations

The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules

1993 • 930 citations

Growth factors in the extracellular matrix

1997 • 879 citations

Eph Receptors and Ligands Comprise Two Major Specificity Subclasses and Are Reciprocally Compartmentalized during Embryogenesis

1996 • 851 citations

In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases

1995 • 849 citations

The kit ligand: A cell surface molecule altered in steel mutant fibroblasts

1990 • 777 citations

Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection map

1995 • 740 citations

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the SId mutant

1991 • 740 citations

Midbrain development induced by FGF8 in the chick embryo

1996 • 734 citations

Ligands for EPH-Related Receptor Tyrosine Kinases that Require Membrane Attachment or Clustering for Activity

1994 • 720 citations

The nerve growth factor: thirty-five years later.

1987 • 720 citations

MEMBRANE-ANCHORED GROWTH FACTORS

1993 • 676 citations

Developmental Neurobiology

1991 • 659 citations

A neu acquaintance for ErbB3 and ErbB4: A role for receptor heterodimerization in growth signaling

1994 • 601 citations

Effects of brain-derived neurotrophic factor on optic axon branching and remodelling in vivo

1995 • 583 citations

The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons

1995 • 566 citations

Nuk Controls Pathfinding of Commissural Axons in the Mammalian Central Nervous System

1996 • 536 citations

The Embryonic Vertebrate Forebrain: the Prosomeric Model

1994 • 530 citations

Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands

1996 • 526 citations

Regulation of signal transduction and signal diversity by receptor oligomerization

1994 • 485 citations

Eph Family Transmembrane Ligands Can Mediate Repulsive Guidance of Trunk Neural Crest Migration and Motor Axon Outgrowth

1997 • 477 citations

Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20.

1993 • 469 citations

Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain

1993 • 452 citations

Segmentation in the vertebrate nervous system

1984 • 440 citations

A Novel Putative Tyrosine Kinase Receptor Encoded by the eph Gene

1987 • 430 citations

An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system

1991 • 427 citations

Topographically Specific Effects of ELF-1 on Retinal Axon Guidance In Vitro and Retinal Axon Mapping In Vivo

1996 • 418 citations

Visuomotor coordination in the newt (triturus viridescens) after regeneration of the optic nerve

1943 • 398 citations

Segmental organization of embryonic diencephalon

1993 • 395 citations

Tyrosine Phosphorylation of Transmembrane Ligands for Eph Receptors

1997 • 394 citations

Interactions of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration

1997 • 389 citations

Control of oligodendrocyte number in the developing rat optic nerve

1994 • 385 citations

Avoidance of posterior tectal membranes by temporal retinal axons

1987 • 370 citations

Role of B61, the Ligand for the Eck Receptor Tyrosine Kinase, in TNF-α-Induced Angiogenesis

1995 • 368 citations

The EphA4 and EphB1 receptor tyrosine kinases and ephrin-B2 ligand regulate targeted migration of branchial neural crest cells

1997 • 343 citations

Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation.

1996 • 334 citations

Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases

1994 • 332 citations

PDZs and Receptor/Channel Clustering: Rounding Up the Latest Suspects

1996 • 322 citations

Capturing genes encoding membrane and secreted proteins important for mouse development.

1995 • 321 citations

Expression of truncated Sek-1 receptor tyrosine kinase disrupts the segmental restriction of gene expression in the Xenopus and zebrafish hindbrain

1995 • 315 citations

Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains.

1991 • 300 citations

The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation

1993 • 297 citations

Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development

1996 • 291 citations

Inaccuracies in initial growth and arborization of chick retinotectal axons followed by course corrections and axon remodeling to develop topographic order

1989 • 273 citations

Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation

1995 • 261 citations

Even-numbered rhombomeres control the apoptotic elimination of neural crest cells from odd-numbered rhombomeres in the chick hindbrain

1993 • 260 citations

Inhibition of Drosophila EGF receptor activation by the secreted protein Argos

1995 • 251 citations

Determination of Neuronal Cell Fate: Lessons from the R7 Neuron of Drosophila

1994 • 245 citations

Biochemical characterization of a putative axonal guidance molecule of the chick visual system

1990 • 241 citations

Shared and distinct functions of RAGS and ELF-1 in guiding retinal axons

1997 • 239 citations

B61 is a ligand for the ECK receptor protein-tyrosine kinase

1994 • 239 citations

cDNA Cloning and Characterization of eck, an Epithelial Cell Receptor Protein-Tyrosine Kinase in the eph/elk Family of Protein Kinases

1990 • 234 citations

A receptor protein tyrosine kinase implicated in the segmental patterning of the hindbrain and mesoderm

1992 • 226 citations

A topographic gradient of molecules in retina can be used to identify neuron position.

1981 • 216 citations

Distinct and Overlapping Expression Patterns of Ligands for Eph-Related Receptor Tyrosine Kinases during Mouse Embryogenesis

1996 • 215 citations

Regulatory gene expression boundaries demarcate sites of neuronal differentiation in the embryonic zebrafish forebrain

1994 • 213 citations

Segmental migration of the hindbrain neural crest does not arise from its segmental generation

1993 • 210 citations

Axonal guidance in the chick visual system: Posterior tectal membanes induce collapse of growth cones from the temporal retina

1990 • 208 citations

Eph receptor tyrosine kinases, axon repulsion, and the development of topographic maps

1995 • 187 citations

Rostral optic tectum acquires caudal characteristics following ectopic Engrailed expression

1996 • 179 citations

Immunolocalization of the Nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis.

1994 • 174 citations

Inhibition of PDGF β Receptor Signal Transduction by Coexpression of a Truncated Receptor

1991 • 173 citations

Inhibition of motor axon growth by T-cadherin substrata

1996 • 169 citations

Identification of a developmentally regulated protein-tyrosine kinase by using anti-phosphotyrosine antibodies to screen a cDNA expression library.

1989 • 165 citations

A Novel Immediate-Early Response Gene of Endothelium Is Induced by Cytokines and Encodes a Secreted Protein

1990 • 159 citations

Detection of Ligands in Regions Anatomically Connected to Neurons Expressing the Eph Receptor Bsk: Potential Roles in Neuron–Target Interaction

1996 • 159 citations

cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases.

1990 • 159 citations

ELF-2, a New Member of the Eph Ligand Family, Is Segmentally Expressed in Mouse Embryos in the Region of the Hindbrain and Newly Forming Somites

1995 • 155 citations

Thyroid Hormone Modulates the Interaction between Iron Regulatory Proteins and the Ferritin mRNA Iron-responsive Element

1996 • 154 citations

Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity.

1994 • 151 citations

Novel protein-tyrosine kinase cDNAs related to fps/fes and eph cloned using anti-phosphotyrosine antibody.

1988 • 151 citations

Graded and Lamina-Specific Distributions of Ligands of EphB Receptor Tyrosine Kinases in the Developing Retinotectal System

1997 • 150 citations

BDNF in the development of the visual system of Xenopus

1994 • 148 citations

Regulation of topographic projection in the brain: Elf-1 in the hippocamposeptal system.

1996 • 147 citations

Ligand Activation of ELK Receptor Tyrosine Kinase Promotes Its Association with Grb10 and Grb2 in Vascular Endothelial Cells

1996 • 145 citations

Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors.

1994 • 141 citations

Membrane-bound LERK2 ligand can signal through three different Eph-related receptor tyrosine kinases.

1995 • 141 citations

Eph Family Receptors and Their Ligands Distribute in Opposing Gradients in the Developing Mouse Retina

1996 • 137 citations

Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain

1994 • 135 citations

Developmental abnormalities in Steel17H mice result from a splicing defect in the steel factor cytoplasmic tail.

1992 • 134 citations

Spatially regulated expression of three receptor tyrosine kinase genes during gastrulation in the zebrafish

1994 • 132 citations

Characterization of a Novel Src-like Adapter Protein That Associates with the Eck Receptor Tyrosine Kinase

1995 • 127 citations

A Role for Gradient en Expression in Positional Specification on the Optic Tectum

1996 • 126 citations

The cytoplasmic carboxy-terminal amino acid specifies cleavage of membrane TGFα into soluble growth factor

1992 • 126 citations

Polarized Expression of the Receptor Protein Tyrosine Kinase Cek5 in the Developing Avian Visual System

1995 • 125 citations

Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis.

1994 • 125 citations

Two Eph receptor tyrosine kinase ligands control axon growth and may be involved in the creation of the retinotectal map in the zebrafish

1997 • 125 citations

Control of Topographic Retinal Axon Branching by Inhibitory Membrane-Bound Molecules

1994 • 122 citations

Retroviral Misexpression ofengrailedGenes in the Chick Optic Tectum Perturbs the Topographic Targeting of Retinal Axons

1996 • 121 citations

Progressive Spatial Restriction ofSek-1andKrox-20Gene Expression during Hindbrain Segmentation

1996 • 119 citations

Effects of mesodermal tissues on avian neural crest cell migration

1991 • 118 citations

Visual projection map specified by topographic expression of transcription factors in the retina

1996 • 118 citations

Position, guidance, and mapping in the developing visual system

1993 • 118 citations

Directional cues for growing axons forming the retinotectal projection

1987 • 117 citations

Overexpression of ERK, an EPH family receptor protein tyrosine kinase, in various human tumors.

1994 • 117 citations

Retinotectal Specificity: Models and Experiments in Search of a Mapping Function

1980 • 116 citations

Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor plate, roof plate and hindbrain segments.

1996 • 115 citations

The Retinoblastoma Susceptibility Gene Product Represses Transcription When Directly Bound to the Promoter

1995 • 115 citations

Function of the Eph-related kinase rtk1 in patterning of the zebrafish forebrain

1996 • 113 citations

Five novel avian Eph-related tyrosine kinases are differentially expressed.

1993 • 112 citations

eph, the largest known family of putative growth factor receptors

1994 • 112 citations

A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein.

1990 • 109 citations

A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn.

1996 • 109 citations

The receptor tyrosine kinase, Cek8, is transiently expressed on subtypes of motoneurons in the spinal cord during development

1996 • 105 citations

AL‐1‐induced Growth Cone Collapse of Rat Cortical Neurons is Correlated with REK7 Expression and Rearrangement of the Actin Cytoskeleton

1997 • 103 citations

Molecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase Htk.

1995 • 101 citations

Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors

1997 • 101 citations

A new member of the Eph family of receptors that lacks protein tyrosine kinase activity.

1996 • 100 citations

The expression of the receptor-protein tyrosine kinase gene, eck, is highly restricted during early mouse development

1994 • 98 citations

Reciprocal Expression of the Eph Receptor Cek5 and Its Ligand(s) in the Early Retina

1997 • 97 citations

Krox-20 is a key regulator of rhombomere-specific gene expression in the developing hindbrain

1997 • 94 citations

A common denominator of growth cone guidance and collapse?

1990 • 93 citations

Isolation and characterization of a novel receptor-type protein tyrosine kinase (hek) from a human pre-B cell line.

1992 • 92 citations

Expression of the BDNF gene in the developing visual system of the chick

1994 • 92 citations

Characterization of a ligand for receptor protein-tyrosine kinase HTK expressed in immature hematopoietic cells.

1996 • 89 citations

A gradient of adhesive specificity in developing avian retina.

1976 • 88 citations

The Expression Pattern of the Mouse Receptor Tyrosine Kinase Gene MDK1 Is Conserved through Evolution and Requires Hoxa-2 for Rhombomere-Specific Expression in Mouse Embryos

1996 • 88 citations

The Eph Kinase Ligand AL-1 Is Expressed by Rostral Muscles and Inhibits Outgrowth from Caudal Neurons

1996 • 84 citations

Expression of theTyro4/Mek4/Cek4Gene Specifically Marks a Subset of Embryonic Motor Neurons and Their Muscle Targets

1996 • 84 citations

Ehk-1 and Ehk-2: two novel members of the Eph receptor-like tyrosine kinase family with distinctive structures and neuronal expression.

1993 • 84 citations

Association of the transmembrane TGF-alpha precursor with a protein kinase complex.

1994 • 83 citations

Epidermal growth factor: Is the precursor a receptor?

1985 • 81 citations

Preferential adhesion of tectal membranes to anterior embryonic chick retina neurites

1981 • 80 citations

Topographic maps and molecular gradients

1993 • 79 citations

Asymmetric expression of a novel homeobox gene in vertebrate sensory organs

1994 • 79 citations

The Eck receptor tyrosine kinase is implicated in pattern formation during gastrulation, hindbrain segmentation and limb development.

1994 • 78 citations

Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube

1998 • 76 citations

Disruption of Cell Adhesion inXenopusEmbryos by Pagliaccio, an Eph-Class Receptor Tyrosine Kinase

1996 • 76 citations

Identification of chicken embryo kinase 5, a developmentally regulated receptor-type tyrosine kinase of the Eph family.

1991 • 76 citations

Expression Pattern of Collagen IX and Potential Role in the Segmentation of the Peripheral Nervous System

1996 • 76 citations

Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily.

1994 • 74 citations

A monoclonal antibody that distinguishes between temporal and nasal retinal axons

1991 • 73 citations

cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases.

1995 • 69 citations

Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins.

1995 • 68 citations

Similarities and Differences in the Way Transmembrane-Type Ligands Interact with the Elk Subclass of Eph Receptors

1996 • 68 citations

Identification of alternatively spliced mRNAs encoding variants of MDK1, a novel receptor tyrosine kinase expressed in the murine nervous system.

1995 • 66 citations

Identification of a new eph-related receptor tyrosine kinase gene from mouse and chicken that is developmentally regulated and encodes at least two forms of the receptor.

1991 • 66 citations

Long-distance intraretinal connections in birds

1987 • 65 citations

Isolation and characterization of Bsk, a growth factor receptor‐like tyrosine kinase associated with the limbic system

1994 • 65 citations

Embryo brain kinase: a novel gene of the eph/elk receptor tyrosine kinase family

1995 • 63 citations

Characterization of the expression of the Cek8 receptor-type tyrosine kinase during development and in tumor cell lines.

1994 • 62 citations

cDNA cloning and characterization of a ligand for the Cek5 receptor protein-tyrosine kinase.

1994 • 62 citations

Germ-line inactivation of the murine Eck receptor tyrosine kinase by gene trap retroviral insertion.

1996 • 60 citations

Neuronal target recognition

1995 • 57 citations

Cek5, a membrane receptor-type tyrosine kinase, is in neurons of the embryonic and postnatal avian brain

1992 • 57 citations

Cloning, characterization, and differential expression of MDK2 and MDK5, two novel receptor tyrosine kinases of the eck/eph family.

1995 • 57 citations

Chromophore-assisted laser inactivation of a repulsive axonal guidance molecule

1996 • 55 citations

Cells and cell‐interactions that guide motor axons in the developing chick embryo

1991 • 51 citations

Pagliaccio, a member of the Eph family of receptor tyrosine kinase genes, has localized expression in a subset of neural crest and neural tissues in Xenopus laevis embryos

1994 • 51 citations

Isolation of LERK-5: A ligand of the eph-related receptor tyrosine kinases

1995 • 50 citations

Embryonic stem cells express multiple Eph-subfamily receptor tyrosine kinases.

1996 • 49 citations

Identification of full-length and truncated forms of Ehk-3, a novel member of the Eph receptor tyrosine kinase family.

1995 • 49 citations

The Receptor Tyrosine Kinase QEK5 mRNA Is Expressed in a Gradient within the Neural Retina and the Tectum

1995 • 48 citations

Engrailed and retinotectal topography

1996 • 46 citations

PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2.

1993 • 46 citations

Transmembrane kit ligand cleavage does not require a signal in the cytoplasmic domain and occurs at a site dependent on spacing from the membrane.

1994 • 44 citations

Molecular cloning of tyrosine kinases in the early Xenopus embryo: Identification of eck‐related genes expressed in cranial neural crest cells of the second (Hyoid) Arch

1995 • 40 citations

Molecular cloning of TOPAP: A topographically graded protein in the developing chick visual system

1995 • 39 citations

B61, a ligand for the Eck receptor protein-tyrosine kinase, exhibits neurotrophic activity in cultures of rat spinal cord neurons

1996 • 39 citations

cDNA Cloning and Characterization of a Cek7 Receptor Protein-tyrosine Kinase Ligand That Is Identical to the Ligand (ELF-1) for the Mek-4 and Sek Receptor Protein-tyrosine Kinases

1995 • 37 citations

Characterisation of five novel zebrafish Eph -related receptor tyrosine kinases suggests roles in patterning the neural plate

1997 • 36 citations

Mechanisms and molecules controlling the development of retinal maps.

1995 • 36 citations

eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases.

1991 • 35 citations

Genomic organization and alternatively processed forms of Cek5, a receptor protein-tyrosine kinase of the Eph subfamily.

1995 • 32 citations

From tags to RAGS: Chemoaffinity finally has receptors and ligands

1995 • 31 citations

Novel members of the eph receptor tyrosine kinase subfamily expressed during Xenopus development.

1995 • 31 citations

Identification of a complete Cek7 receptor protein tyrosine kinase coding sequence and cDNAs of alternatively spliced transcripts

1994 • 29 citations

Expression of an amphibian homolog of the Eph family of receptor tyrosine kinases is developmentally regulated.

1995 • 28 citations

Patterning of retinotectal connections in the vertebrate visual system

1992 • 28 citations

cDNA Cloning, Molecular Characterization, and Chromosomal Localization ofNET(EPHT2),a HumanEPH-Related Receptor Protein-Tyrosine Kinase Gene Preferentially Expressed in Brain

1995 • 27 citations

The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands

1997 • 25 citations

Embryonic expression of eph signalling factors in Xenopus

1996 • 16 citations

Molecular Cloning of Two Novel Transmembrane Ligands for Eph-Related Kinases (LERKS) that are Related to LERK-2

1996 • 16 citations

Characterisation of Cek-11, a member of the EPH-receptor family in the chick embryo.

1996 • 2 citations