Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses

Cell Migration: A Physically Integrated Molecular Process

1996 • 3,909 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

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Proteins regulating Ras and its relatives

1993 • 1,930 citations

Actin-Based Cell Motility and Cell Locomotion

1996 • 1,536 citations

Regulation of transcription by MAP kinase cascades

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Receptor Protein-Tyrosine Kinases and Their Signal Transduction Pathways

1994 • 1,309 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

THE EPHRINS AND EPH RECEPTORS IN NEURAL DEVELOPMENT

1998 • 1,082 citations

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

1997 • 929 citations

In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases

1995 • 849 citations

Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton

1997 • 802 citations

Ligands for EPH-Related Receptor Tyrosine Kinases that Require Membrane Attachment or Clustering for Activity

1994 • 720 citations

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

1992 • 692 citations

Trk receptors use redundant signal transduction pathways involving SHC and PLC-γ1 to mediate NGF responses

1994 • 538 citations

Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation.

1995 • 535 citations

Suppression of Integrin Activation: A Novel Function of a Ras/Raf-Initiated MAP Kinase Pathway

1997 • 501 citations

Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

1996 • 479 citations

Eph Family Transmembrane Ligands Can Mediate Repulsive Guidance of Trunk Neural Crest Migration and Motor Axon Outgrowth

1997 • 477 citations

PDZ Proteins Bind, Cluster, and Synaptically Colocalize with Eph Receptors and Their Ephrin Ligands

1998 • 455 citations

Regulation of chemotaxis by the platelet-derived growth factor receptor-β

1994 • 441 citations

Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses

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Topographically Specific Effects of ELF-1 on Retinal Axon Guidance In Vitro and Retinal Axon Mapping In Vivo

1996 • 418 citations

Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis

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Integrin Activation by R-ras

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The Phosphorylation State of Eucaryotic Initiation Factor 2 Alters Translational Efficiency of Specific mRNAs

1989 • 393 citations

Association of mitogen-activated protein kinase with the microtubule cytoskeleton.

1995 • 354 citations

Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases.

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Activation of Both MAP Kinase and Phosphatidylinositide 3-Kinase by Ras Is Required for Hepatocyte Growth Factor/Scatter Factor–induced Adherens Junction Disassembly

1998 • 330 citations

Specific and redundant roles of Src and Fyn in organizing the cytoskeleton

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Autoregulatory Mechanisms in Protein-tyrosine Kinases

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Inactivation of isocitrate dehydrogenase by phosphorylation is mediated by the negative charge of the phosphate.

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A Phosphatidylinositol-3 Kinase Binds to Platelet-Derived Growth Factor Receptors through a Specific Receptor Sequence Containing Phosphotyrosine

1991 • 294 citations

Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells

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Fascin, an Actin-bundling Protein, Induces Membrane Protrusions and Increases Cell Motility of Epithelial Cells

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Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor.

1993 • 238 citations

Mitogen-Activated Protein Kinases (Erk1,2) Phosphorylate Lys-Ser-Pro (KSP) Repeats in Neurofilament Proteins NF-H and NF-M

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Guanine nucleotide exchange factors: Activators of the Ras superfamily of proteins

1995 • 217 citations

The Eph family of receptors

1997 • 205 citations

PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor

1998 • 202 citations

The Junction-associated Protein AF-6 Interacts and Clusters with Specific Eph Receptor Tyrosine Kinases at Specialized Sites of Cell–Cell Contact in the Brain

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Rho family small GTP-binding proteins in growth cone signalling

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Independent mechanisms account for the regulation by protein kinase C of the epidermal growth factor receptor affinity and tyrosine-protein kinase activity.

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Phosphorylation of serine 985 negatively regulates the hepatocyte growth factor receptor kinase.

1994 • 154 citations

Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity.

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Nck Recruitment to Eph Receptor, EphB1/ELK, Couples Ligand Activation to c-Jun Kinase

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Signaling by Eph receptors and their ephrin ligands

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Constitutive activation of Mek1 by mutation of serine phosphorylation sites.

1994 • 145 citations

Ligand Activation of ELK Receptor Tyrosine Kinase Promotes Its Association with Grb10 and Grb2 in Vascular Endothelial Cells

1996 • 145 citations

Aberrant Stress-induced Phosphorylation of Perikaryal Neurofilaments

1996 • 132 citations

The Rho's progress: a potential role during neuritogenesis for the Rho family of GTPases

1995 • 129 citations

Formation of stable microspikes containing actin and the 55 kDa actin bundling protein, fascin, is a consequence of cell adhesion to thrombospondin-1: implications for the anti-adhesive activities of thrombospondin-1

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Multifunctional calcium/calmodulin-dependent protein kinase made calcium-independent for functional studies

1990 • 127 citations

Polarized Expression of the Receptor Protein Tyrosine Kinase Cek5 in the Developing Avian Visual System

1995 • 125 citations

Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region

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A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine.

1991 • 119 citations

Common structural changes accompany the functional inactivation of HPr by seryl phosphorylation or by serine to aspartate substitution

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AL‐1‐induced Growth Cone Collapse of Rat Cortical Neurons is Correlated with REK7 Expression and Rearrangement of the Actin Cytoskeleton

1997 • 103 citations

Characterization of Cell–Matrix Adhesion Requirements for the Formation of Fascin Microspikes

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Reciprocal Expression of the Eph Receptor Cek5 and Its Ligand(s) in the Early Retina

1997 • 97 citations

The Eph family in the patterning of neural development

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Tyrosine phosphorylation of L1 family adhesion molecules: Implication of the Eph kinase Cek5

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Study of Proline-Directed Protein Kinases Involved in Phosphorylation of the Heavy Neurofilament Subunit

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Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells.

1994 • 88 citations

Multiple in Vivo Tyrosine Phosphorylation Sites in EphB Receptors

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Identification of chicken embryo kinase 5, a developmentally regulated receptor-type tyrosine kinase of the Eph family.

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The Eph family: a multitude of receptors that mediate cell recognition signals

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cDNA cloning and characterization of a ligand for the Cek5 receptor protein-tyrosine kinase.

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Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions

1998 • 56 citations

Lerk2 (Ephrin-B1) Is a Collapsing Factor for a Subset of Cortical Growth Cones and Acts by a Mechanism Different from AL-1 (Ephrin-A5)

1997 • 47 citations

NG2 proteoglycan and the actin-binding protein fascin define separate populations of actin-containing filopodia and lamellipodia during cell spreading and migration.

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Tyrosine 569 in the c-Fms juxtamembrane domain is essential for kinase activity and macrophage colony-stimulating factor-dependent internalization.

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Care of the Grieving Parent with Special Reference to Stillbirth

1990 • 3 citations