Tolerance and Autoimmunity

Somatic generation of antibody diversity

1983 • 3,275 citations

A Short-Term Study of Chimeric Monoclonal Antibody cA2 to Tumor Necrosis Factor α for Crohn's Disease

1997 • 3,152 citations

Lymphocyte Homing and Homeostasis

1996 • 2,934 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

Randomised double-blind placebo-controlled study of interferon β-1a in relapsing/remitting multiple sclerosis

1998 • 2,049 citations

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

1995 • 2,028 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Innate Immunity

2000 • 1,715 citations

Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis

1994 • 1,695 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

Treatment of Rheumatoid Arthritis with a Recombinant Human Tumor Necrosis Factor Receptor (p75)–Fc Fusion Protein

1997 • 1,651 citations

The Immune System

2000 • 1,647 citations

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

1988 • 1,562 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.

1996 • 1,498 citations

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1995 • 1,477 citations

Positional cloning of the APECED gene

1997 • 1,385 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

Long-Term Clinical Efficacy of Grass-Pollen Immunotherapy

1999 • 1,341 citations

The immune system evolved to discriminate infectious nonself from noninfectious self

1992 • 1,324 citations

Mutations in Fas Associated with Human Lymphoproliferative Syndrome and Autoimmunity

1995 • 1,306 citations

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

1996 • 1,281 citations

Regulatory T Cells in Autoimmmunity

2000 • 1,267 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

1997 • 1,155 citations

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

1999 • 1,131 citations

Oral gene delivery with chitosan–DNA nanoparticles generates immunologic protection in a murine model of peanut allergy

1999 • 1,100 citations

Age, Thymopoiesis, and CD4+ T-Lymphocyte Regeneration after Intensive Chemotherapy

1995 • 1,066 citations

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

1989 • 1,015 citations

TNF neutralization in MS

1999 • 968 citations

Amino Acid Homology Between the Encephalitogenic Site of Myelin Basic Protein and Virus: Mechanism for Autoimmunity

1985 • 941 citations

The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

1997 • 931 citations

Placebo-controlled multicentre randomised trial of interferon β-1b in treatment of secondary progressive multiple sclerosis

1998 • 931 citations

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

1996 • 909 citations

Identification of autoantibodies associated with myelin damage in multiple sclerosis

1999 • 881 citations

Immunologically Privileged Sites

1978 • 815 citations

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

1997 • 806 citations

Encephalitogenic potential of the myelin basic protein peptide (amino acids 83–99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand

2000 • 805 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

1991 • 766 citations

Discovery and analysis of inflammatory disease-related genes using cDNA microarrays

1997 • 740 citations

Maturation, Activation, and Protection of Dendritic Cells Induced by Double-stranded RNA

1999 • 727 citations

Altered Peptide Ligand–Induced Partial T Cell Activation: Molecular Mechanisms and Role in T Cell Biology

1996 • 698 citations

From Systemic T Cell Self-Reactivity to Organ-Specific Autoimmune Disease via Immunoglobulins

1999 • 689 citations

Treatment of Murine Lupus with CTLA4Ig

1994 • 683 citations

Allergen Immunotherapy: Therapeutic Vaccines for Allergic Diseases

1998 • 678 citations

Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry

1998 • 669 citations

Allergen-specific Th1 cells fail to counterbalance Th2 cell–induced airway hyperreactivity but cause severe airway inflammation

1999 • 642 citations

Effects of Oral Administration of Type II Collagen on Rheumatoid Arthritis

1993 • 634 citations

Arthritis Provoked by Linked T and B Cell Recognition of a Glycolytic Enzyme

1999 • 620 citations

Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases

1998 • 601 citations

The NOD mouse model of type 1 diabetes: As good as it gets?

1999 • 592 citations

Double-Blind Pilot Trial of Oral Tolerization with Myelin Antigens in Multiple Sclerosis

1993 • 592 citations

Microbial Lipopeptides Induce the Production of IL-17 in Th Cells

2000 • 589 citations

Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin.

1991 • 562 citations

Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading

1997 • 558 citations

Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells

1994 • 545 citations

High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice

1994 • 544 citations

T Cell Deletion in High Antigen Dose Therapy of Autoimmune Encephalomyelitis

1994 • 530 citations

Molecular Mimicry and Autoimmunity

1999 • 523 citations

Molecular identification of a novel retrovirus repeatedly isolated from patients with multiple sclerosis

1997 • 477 citations

The Immune System

2000 • 473 citations

Somatic recombination in a murine T-cell receptor gene

1984 • 468 citations

Epidemiologic evidence for multiple sclerosis as an infection

1993 • 467 citations

Arthritis induced by a T-lymphocyte clone that responds to Mycobacterium tuberculosis and to cartilage proteoglycans.

1985 • 463 citations

Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin.

1983 • 441 citations

Myelin Basic Protein–specific T Helper 2 (Th2) Cells Cause Experimental Autoimmune Encephalomyelitis in Immunodeficient Hosts Rather than Protect Them from the Disease

1997 • 433 citations

IL-10 is a key cytokine in psoriasis. Proof of principle by IL-10 therapy: a new therapeutic approach.

1998 • 414 citations

T-Independent Immune Response: New Aspects of B Cell Biology

2000 • 413 citations

Expansion or Elimination of B Cells In Vivo: Dual Roles for CD40- and Fas (CD95)-Ligands Modulated by the B Cell Antigen Receptor

1996 • 405 citations

Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells

2000 • 399 citations

Costimulatory regulation of T cell function

1999 • 391 citations

A Critical Role for Complement in Maintenance of Self-Tolerance

1998 • 373 citations

Molecular mimicry in virus infection: crossreaction of measles virus phosphoprotein or of herpes simplex virus protein with human intermediate filaments.

1983 • 363 citations

Suppression of type II collagen-induced arthritis by intragastric administration of soluble type II collagen.

1986 • 357 citations

A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity

1994 • 347 citations

A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus

1998 • 340 citations

T Cell Stimulation In Vivo by Lipopolysaccharide (LPS)

1997 • 335 citations

Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice.

1993 • 334 citations

A search for type 1 diabetes susceptibility genes in families from the United Kingdom

1998 • 329 citations

Blockade of T Lymphocyte Costimulation with Cytotoxic T Lymphocyte–Associated Antigen 4–Immunoglobulin (Ctla4ig) Reverses the Cellular Pathology of Psoriatic Plaques, Including the Activation of Keratinocytes, Dendritic Cells, and Endothelial Cells

2000 • 322 citations

CD4+ T Cell Help Impairs CD8+ T Cell Deletion Induced by Cross-presentation of Self-Antigens and Favors Autoimmunity

1997 • 320 citations

Late Complications of Immune Deviation Therapy in a Nonhuman Primate

1996 • 319 citations

Multiple sclerosis: Comparison of copolymer-1- reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells

2000 • 304 citations

Insulin prophylaxis in individuals at high risk of type 1 diabetes

1993 • 303 citations

Regulatory CD4+ T Cells Expressing Endogenous T Cell Receptor Chains Protect Myelin Basic Protein–specific Transgenic Mice from Spontaneous Autoimmune Encephalomyelitis

1998 • 299 citations

Suppression of experimental autoimmune encephalomyelitis by the oral administration of myelin basic protein

1988 • 291 citations

High Frequency of Autoreactive Myelin Proteolipid Protein–Specific T Cells in the Periphery of Naive Mice

2000 • 275 citations

Regulatory T Cells in the Control of Autoimmunity: the Essential Role of Transforming Growth Factor β and Interleukin 4 in the Prevention of Autoimmune Thyroiditis in Rats by Peripheral CD4+CD45RC− Cells and CD4+CD8− Thymocytes

1999 • 269 citations

Induction of Autoimmune Diabetes by Oral Administration of Autoantigen

1996 • 261 citations

Treatment of severe systemic lupus erythematosus with high-dose chemotherapy and haemopoietic stem-cell transplantation: a phase I study

2000 • 245 citations

Prevention and amelioration of collagen‐induced arthritis by blockade of the CD28 co‐stimulatory pathway: requirement for both B7‐1 and B7‐2

1996 • 244 citations

Sequence Homology Between Certain Viral Proteins and Proteins Related to Encephalomyelitis and Neuritis

1985 • 243 citations

Macrophage-dependent Apoptosis of CD4+ T Lymphocytes from HIV-infected Individuals Is Mediated by FasL and Tumor Necrosis Factor

1997 • 242 citations

Oral insulin administration and residual (β-cell function in recent-onset type 1 diabetes: a multicentre randomised controlled trial

2000 • 239 citations

Does rheumatoid arthritis remit during pregnancy and relapse postpartum?: Results from a nationwide study in the United Kingdom performed prospectively from late pregnancy

1999 • 231 citations

Levels of Peripheral T Cell Tolerance Induced by Different Doses of Tolerogen

1994 • 229 citations

Activation changes the spectrum but not the diversity of genes expressed by T cells

1999 • 227 citations

Receptor Selection in B and T Lymphocytes

2000 • 226 citations

Interleukin 10 Secretion and Impaired Effector Function of Major Histocompatibility Complex Class II–restricted T Cells Anergized In Vivo

1998 • 225 citations

T Helper 2 (Th2) T Cells Induce Acute Pancreatitis and Diabetes in Immune-compromised Nonobese Diabetic (NOD) Mice

1997 • 223 citations

C3d enhancement of antibodies to hemagglutinin accelerates protection against influenza virus challenge

2000 • 218 citations

Identification of candidate T-cell epitopes and molecular mimics in chronic Lyme disease

1999 • 217 citations

Genetic control of arthritis onset, severity and chronicity in a model for rheumatoid arthritis in rats

1998 • 215 citations

How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis

2000 • 212 citations

Studies on the Chemistry of Anaphylaxis (III). Experiments with Isolated Proteins, Especially those of the Hen's Egg

1911 • 211 citations

Cellular Sites of Immunologic Unresponsiveness

1970 • 202 citations

Epistatic Modifiers of Autoimmunity in a Murine Model of Lupus Nephritis

1999 • 200 citations

B‐lymphocyte quiescence, tolerance and activation as viewed by global gene expression profiling on microarrays

2000 • 186 citations

The Role of Autoantibodies in Autoimmune Disease

1993 • 184 citations

A Range of CD4 T Cell Tolerance: Partial Inactivation to Organ-Specific Antigen Allows Nondestructive Thyroiditis or Insulitis

1997 • 178 citations

In Autoimmune Diabetes the Transition from Benign to Pernicious Insulitis Requires an Islet Cell Response to Tumor Necrosis Factor α

1999 • 164 citations

The NOD Idd9 Genetic Interval Influences the Pathogenicity of Insulitis and Contains Molecular Variants of Cd30, Tnfr2, and Cd137

2000 • 163 citations

Long-term inhibition of murine experimental autoimmune encephalomyelitis using CTLA-4-Fc supports a key role for CD28 costimulation.

1995 • 160 citations

CD4+ T Cells Prevent Spontaneous Experimental Autoimmune Encephalomyelitis in Anti–Myelin Basic Protein T Cell Receptor Transgenic Mice

1998 • 159 citations

Predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology.

1998 • 156 citations

Treatment of Uveitis by Oral Administration of Retinal Antigens: Results of a Phase I/II Randomized Masked Trial

1997 • 155 citations

Immune Tolerance in Hemophilia-Principal Results from the International Registry

1994 • 140 citations

The “Clonal Selection Hypothesis” and Current Concepts of B Cell Tolerance

1996 • 126 citations

T cell receptor antagonist peptides are highly effective inhibitors of experimental allergic encephalomyelitis

1994 • 123 citations

Limited capacity for tolerization of CD4+ T cells specific for a pancreatic β cell neo-antigen

1995 • 121 citations

Cutting Edge: Predictable TCR Antigen Recognition Based on Peptide Scans Leads to the Identification of Agonist Ligands with No Sequence Homology

1998 • 118 citations

Regulation of Interleukin (IL)-12 Receptor β2 Subunit Expression by Endogenous IL-12: A Critical Step in the Differentiation of Pathogenic Autoreactive T Cells

1999 • 103 citations

Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells

2000 • 102 citations

T cell autoreactivity to insulin in diabetic and related non-diabetic individuals.

1988 • 100 citations

Cutting Edge: C1q Protects Against the Development of Glomerulonephritis Independently of C3 Activation

1999 • 86 citations

Outcome of rheumatoid arthritis and psoriasis following autologous stem cell transplantation for hematologic malignancy

1997 • 82 citations

Experimental mucosal induction of uveitis with the 60-kDa heat shock protein-derived peptide 336 – 351

1998 • 79 citations

Cross-Reactivity of Myelin Basic Protein-Specific T Cells with Multiple Microbial Peptides: Experimental Autoimmune Encephalomyelitis Induction in TCR Transgenic Mice

1999 • 76 citations

Early infection and subsequent insulin dependent diabetes

1997 • 76 citations

Immunological Treatment of Autoimmune Diseases

1998 • 75 citations

Genetics of Multiple Sclerosis

1998 • 74 citations

Immune Response to Human Papillomaviruses and the Prospects for Human Papillomavirus-Specific Immunisation

1994 • 72 citations

Self-reactive B Cells Are Not Eliminated or Inactivated by Autoantigen Expressed on Thyroid Epithelial Cells

1997 • 70 citations

Lack of efficacy of oral bovine type II collagen added to existing therapy in rheumatoid arthritis

1999 • 69 citations

Tolerance induction to myelin basic protein by intravenous synthetic peptides containing epitope P85VVHFFKNIVTP96 in chronic progressive multiple sclerosis

1997 • 66 citations

Pertussis toxin prevents the induction of peripheral T cell anergy and enhances the T cell response to an encephalitogenic peptide of myelin basic protein.

1991 • 65 citations

Lymphocyte Survival--Ignorance Is BLys

2000 • 58 citations

Two Genetic Loci Regulate T Cell–Dependent Islet Inflammation and Drive Autoimmune Diabetes Pathogenesis

2000 • 57 citations

Peripheral tolerance in T cell receptor‐transgenic mice: Evidence for T cell anergy

1996 • 54 citations

Multiple cross-reactive self-ligands forBorrelia burgdorferi-specific HLA-DR4-restricted T cells

2000 • 54 citations

Risk factors for allergy

1999 • 51 citations

T Cells Recognizing Multiple Peptides of Myelin Basic Protein are Found in Blood and Enriched in Cerebrospinal Fluid in Optic Neuritis and Multiple Sclerosis

1993 • 43 citations

Treatment of Experimental Allergic Encephalomyelitis with Encephalitogenic Basic Proteins

1972 • 34 citations

Clinical and Immunologic Effects of Component Peptides in Allervax<sup>®</sup> Cat

1997 • 27 citations

Myelin-specific T lymphocytes in multiple sclerosis patients and healthy individuals

1988 • 19 citations