Increased antigen presenting cell‐mediated T cell activation in mice and patients without the autoimmune regulator

Tolerogenic Dendritic Cells

2003 • 3,131 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

Identification of an inducible endothelial-leukocyte adhesion molecule.

1987 • 1,639 citations

Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements

1998 • 1,460 citations

T-Cell Function and Migration — Two Sides of the Same Coin

2000 • 1,437 citations

T Cell Anergy

2003 • 1,418 citations

Positional cloning of the APECED gene

1997 • 1,385 citations

A Controlled Trial of Natalizumab for Relapsing Multiple Sclerosis

2003 • 1,228 citations

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

1997 • 1,155 citations

Clinical Variation of Autoimmune Polyendocrinopathy–Candidiasis–Ectodermal Dystrophy (APECED) in a Series of 68 Patients

1990 • 1,041 citations

C-type lectin receptors on dendritic cells and langerhans cells

2002 • 824 citations

Natalizumab for Active Crohn's Disease

2003 • 815 citations

Aire regulates negative selection of organ-specific T cells

2003 • 789 citations

Autoimmune Polyendocrine Syndromes

2004 • 650 citations

The Cellular Mechanism of Aire Control of T Cell Tolerance

2005 • 622 citations

Activation‐induced cell death in T cells

2003 • 613 citations

Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

2005 • 540 citations

Self- and Nonself-Recognition by C-Type Lectins on Dendritic Cells

2004 • 500 citations

Central Tolerance to Tissue-specific Antigens Mediated by Direct and Indirect Antigen Presentation

2004 • 474 citations

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

2002 • 463 citations

Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in human microvascular endothelial cells.

1996 • 418 citations

Identification of α-Fodrin as a Candidate Autoantigen in Primary Sjögren's Syndrome

1997 • 400 citations

An autosomal locus causing autoimmune disease: autoimmune polyglandular disease type I assigned to chromosome 21

1994 • 379 citations

Impact of Negative Selection on the T Cell Repertoire Reactive to a Self-Peptide

2000 • 377 citations

Mutations in the AIRE Gene: Effects on Subcellular Location and Transactivation Function of the Autoimmune Polyendocrinopathy-Candidiasis–Ectodermal Dystrophy Protein

2000 • 358 citations

Speed congenics: a classic technique in the fast lane (relatively speaking)

1997 • 347 citations

Polyglandular autoimmune syndrome type I among Iranian Jews.

1992 • 308 citations

Vascular and nonvascular expression of INCAM-110. A target for mononuclear leukocyte adhesion in normal and inflamed human tissues.

1991 • 306 citations

Adhesion of Human B Cells to Germinal Centers in Vitro Involves VLA-4 and INCAM-110

1990 • 295 citations

Autoimmune Regulator Is Expressed in the Cells Regulating Immune Tolerance in Thymus Medulla

1999 • 293 citations

Origin and differentiation of dendritic cells

2001 • 291 citations

Gene Dosage–limiting Role ofAirein Thymic Expression, Clonal Deletion, and Organ-specific Autoimmunity

2004 • 291 citations

Development of Autoimmunity against Transcriptionally Unrepressed Target Antigen in the Thymus of Aire-Deficient Mice

2005 • 287 citations

IL-4 acts synergistically with IL-1 beta to promote lymphocyte adhesion to microvascular endothelium by induction of vascular cell adhesion molecule-1.

1990 • 286 citations

Normal Thymic Architecture and Negative Selection Are Associated with Aire Expression, the Gene Defective in the Autoimmune-Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED)

2000 • 261 citations

A common mutation in Sardinian autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy patients

1998 • 244 citations

The Autoimmune Regulator Protein Has Transcriptional Transactivating Properties and Interacts with the Common Coactivator CREB-binding Protein

2000 • 239 citations

Vascular cell adhesion molecule 1 induces T-cell antigen receptor-dependent activation of CD4+T lymphocytes.

1991 • 234 citations

Prevalence and Clinical Associations of 10 Defined Autoantibodies in Autoimmune Polyendocrine Syndrome Type I

2004 • 234 citations

Modifier loci condition autoimmunity provoked by Aire deficiency

2005 • 233 citations

Two different cytochrome P450 enzymes are the adrenal antigens in autoimmune polyendocrine syndrome type I and Addison's disease.

1993 • 203 citations

RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse

2000 • 185 citations

Altered Antigen Presentation in Mice Lacking H2-O

1998 • 180 citations

Heterogeneity of Endothelial Cells from Different Organ Sites in T-Cell Subset Recruitment

2003 • 148 citations

AIRE deficiency in thymus of 2 patients with Omenn syndrome

2005 • 145 citations

AIRE Functions As an E3 Ubiquitin Ligase

2004 • 145 citations

AIRE deficiency in thymus of 2 patients with Omenn syndrome

2005 • 144 citations

Expression of AIRE gene in peripheral monocyte/dendritic cell lineage

2002 • 130 citations

Subcellular Localization of the Autoimmune Regulator Protein

2001 • 127 citations

Chromosomal clustering of genes controlled by the aire transcription factor

2005 • 126 citations

The Activity of Soluble VCAM-1 in Angiogenesis Stimulated by IL-4 and IL-13

2000 • 126 citations

Genetic homogeneity of autoimmune polyglandular disease type I.

1996 • 117 citations

The Polyglandular Failure Syndrome: Disease Inheritance, HLA Type, and Immune Function

1979 • 106 citations

Subcellular Location and Expression Pattern of Autoimmune Regulator (Aire), the Mouse Orthologue for Human Gene Defective in Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED)

2001 • 97 citations

Systematic mutagenesis of the functional domains of AIRE reveals their role in intracellular targeting

2002 • 94 citations

The Expression of Autoimmune Polyglandular Disease Type I Appears Associated With Several HLA-A Antigens But Not With HLA-DR*

1988 • 93 citations

NMR Structure of the First PHD Finger of Autoimmune Regulator Protein (AIRE1)

2005 • 89 citations

Cytochrome P450IA2 and aromatic <scp>l</scp>‐amino acid decarboxylase are hepatic autoantigens in autoimmune polyendocrine syndrome type I

1997 • 85 citations

The clearance of apoptotic cells: implications for autoimmunity

2002 • 76 citations

Complement component C1 and the collectins – first-line defense molecules in innate and acquired immunity

2002 • 73 citations

Antibodies to proteinase 3 mediate expression of vascular cell adhesion molecule-1 (VCAM-1)

1996 • 67 citations

Lymphocyte adhesion to cultured Peyer's patch high endothelial venule cells is mediated by organ-specific homing receptors and can be regulated by cytokines.

1990 • 58 citations

Inhibition of T cell costimulation by VCAM-1 prevents murine graft-versus-host disease across minor histocompatibility barriers.

1995 • 56 citations

Autoimmune regulator induced changes in the gene expression profile of human monocyte-dendritic cell-lineage

2004 • 54 citations

The Impact of H2-DM on Humoral Immune Responses

2001 • 36 citations

Aire downregulates multiple molecules that have contradicting immune-enhancing and immune-suppressive functions

2004 • 24 citations

Stimulation of Macrophage Synthesis of Complement Clq by Interferon-γ Mediated by Endogenous Interferon-α/β

1996 • 8 citations