UV-induced signal transduction

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The Metabolic Basis of Inherited Disease.

1988 • 7,933 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

DNA Repair and Mutagenesis

2006 • 4,725 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

1995 • 2,441 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

DNA repair and mutagenesis

1996 • 2,289 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

1995 • 1,739 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway

1995 • 1,453 citations

Selective interaction of JNK protein kinase isoforms with transcription factors.

1996 • 1,333 citations

Regulation of transcription by MAP kinase cascades

1996 • 1,330 citations

Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.

1989 • 1,273 citations

Signal transduction via the MAP kinases: proceed at your own RSK.

1993 • 1,262 citations

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

1988 • 1,256 citations

SIGNALLING BY RECEPTOR TYROSINE KINASES

1993 • 1,098 citations

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

1991 • 1,071 citations

Parallel signal processing among mammalian MAPKs

1995 • 1,015 citations

The metabolic basis of inherited disease

1995 • 1,007 citations

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

1992 • 980 citations

Site-Specific Phosphorylation of IκBα by a Novel Ubiquitination-Dependent Protein Kinase Activity

1996 • 960 citations

MAPKs: new JNK expands the group

1994 • 949 citations

Bone and haematopoietic defects in mice lacking c-fos

1992 • 939 citations

Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element

1995 • 935 citations

The mammalian ultraviolet response is triggered by activation of src tyrosine kinases

1992 • 874 citations

UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells.

1984 • 874 citations

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.

1994 • 850 citations

Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?

1993 • 799 citations

DNA Repair Helicase: a Component of BTF2 (TFIIH) Basic Transcription Factor

1993 • 795 citations

Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB

1994 • 732 citations

12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region.

1987 • 699 citations

High levels of p53 protein in UV-irradiated normal human skin.

1993 • 689 citations

Ternary complex factors: growth factor regulated transcriptional activators

1994 • 686 citations

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation.

1995 • 667 citations

NF-kappa B activation by ultraviolet light not dependent on a nuclear signal

1993 • 646 citations

Pleiotropic effects of a null mutation in the c-fos proto-oncogene

1992 • 643 citations

DNA damage-inducible transcripts in mammalian cells.

1988 • 613 citations

ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents.

1995 • 603 citations

Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters

1988 • 597 citations

p53 modulation of TFIIH–associated nucleotide excision repair activity

1995 • 555 citations

The genetic defect in Cockayne syndrome is associated with a defect in repair of UV-induced DNA damage in transcriptionally active DNA.

1990 • 552 citations

UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein.

1989 • 549 citations

c-Jun is essential for normal mouse development and hepatogenesis

1993 • 543 citations

Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents.

1996 • 523 citations

ATF-2 contains a phosphorylation-dependent transcriptional activation domain.

1995 • 504 citations

Transcription-Coupled Repair and Human Disease

1994 • 501 citations

Activation of the c-Abl tyrosine kinase in the stress response to DMA-damaging agents

1995 • 486 citations

The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH

1995 • 485 citations

Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II

1994 • 473 citations

Diversity in function and regulation of MAP kinase pathways

1994 • 469 citations

Involvement of growth factor receptors in the mammalian UVC response

1994 • 456 citations

A presumed DNA helicase encoded by ERCC-3 is involved in the human repair disorders xeroderma pigmentosum and Cockayne's syndrome

1990 • 440 citations

COMMON THEMES IN ASSEMBLY AND FUNCTION OF EUKARYOTIC TRANSCRIPTION COMPLEXES

1995 • 434 citations

Environmental UV Photobiology

1993 • 430 citations

Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23.

1994 • 394 citations

A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture.

1993 • 393 citations

Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element.

1988 • 391 citations

Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway.

1994 • 389 citations

Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein.

1993 • 380 citations

Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage.

1995 • 365 citations

c-fos is required for malignant progression of skin tumors

1995 • 353 citations

General Initiation Factors for RNA Polymerase II

1993 • 346 citations

Occupation of the c-fos serum response element in vivo by a multi-protein complex is unaltered by growth factor induction

1989 • 346 citations

Action spectrum for DMA damage in alfalfa lowers predicted impact of ozone depletion

1992 • 327 citations

Wavelength dependence of pyrimidine dimer formation in DNA of human skin irradiated in situ with ultraviolet light.

1989 • 313 citations

Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents

1993 • 305 citations

Deficient repair of the transcribed strand of active genes in Cockayne's syndrome cells

1993 • 292 citations

COMMENTARY: p⁵³ Tumor suppressor gene: from the basic research laboratory to the clinic—an abridged historical perspective

1996 • 284 citations

MAMMALIAN GENES INDUCED BY RADIATION; Activation of Genes Associated with Growth Control

1992 • 284 citations

DNA damage enhances melanogenesis.

1996 • 284 citations

UV activates growth factor receptors via reactive oxygen intermediates.

1996 • 281 citations

ERCC2: cDNA cloning and molecular characterization of a human nucleotide excision repair gene with high homology to yeast RAD3.

1990 • 274 citations

Activation of the c-fos gene by UV and phorbol ester: different signal transduction pathways converge to the same enhancer element.

1988 • 271 citations

The Atmosphere and UV-B Radiation at Ground Level

1993 • 269 citations

UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase.

1993 • 262 citations

Activation of human immunodeficiency virus type 1 by DNA damage in human cells

1988 • 256 citations

Transcription-coupled repair removes both cyclobutane pyrimidine dimers and 6-4 photoproducts with equal efficiency and in a sequential way from transcribed DNA in xeroderma pigmentosum group C fibroblasts.

1995 • 244 citations

Protein Synthesis Inhibitors Reveal Differential Regulation of Mitogen-Activated Protein Kinase and Stress-Activated Protein Kinase Pathways That Converge on Elk-1

1995 • 243 citations

Expression cloning of a human DNA repair gene involved in xeroderma pigmentosum group C

1992 • 242 citations

The residual repair capacity of xeroderma pigmentosum complementation group C fibroblasts is highly specific for transcriptionally active DNA

1990 • 231 citations

U.v.-induced nuclear accumulation of p53 is evoked through DNA damage of actively transcribed genes independent of the cell cycle.

1994 • 227 citations

The p53-dependent gamma-ray response of GADD45.

1994 • 225 citations

UV Irradiation and Heat Shock Mediate JNK Activation via Alternate Pathways

1995 • 223 citations

Induction of metallothionein and other mRNA species by carcinogens and tumor promoters in primary human skin fibroblasts.

1986 • 215 citations

Induction of fos RNA by DNA-damaging agents.

1989 • 209 citations

Fos is an essential component of the mammalian UV response.

1995 • 200 citations

Complementation of DNA repair in xeroderma pigmentosum group A cell extracts by a protein with affinity for damaged DNA.

1991 • 200 citations

MEK Kinase Is Involved in Tumor Necrosis Factor α-Induced NF-κB Activation and Degradation of IκB-α

1996 • 197 citations

Molecular cloning and biological characterization of a human gene, ERCC2, that corrects the nucleotide excision repair defect in CHO UV5 cells.

1988 • 193 citations

Activation of ternary complex factor Elk-1 by stress-activated protein kinases

1995 • 190 citations

Response to adversity: molecular control of gene activation following genotoxic stress.

1991 • 189 citations

Effect of Antisense c- raf -1 on Tumorigenicity and Radiation Sensitivity of a Human Squamous Carcinoma

1989 • 189 citations

DNA damage-induced gene expression: Signal transduction and relation to growth factor signaling

1992 • 187 citations

Hydrogen peroxide preferentially enhances the tyrosine phosphorylation of epidermal growth factor receptor

1995 • 187 citations

Radiation induction of immediate early genes: Effectors of the radiation-stress response

1994 • 174 citations

UVB Light Induces Nuclear Factor κB (NFκB) Activity Independently from Chromosomal DNA Damage in Cell-Free Cytosolic Extracts

1994 • 165 citations

UV activation of receptor tyrosine kinase activity.

1995 • 164 citations

Xeroderma pigmentosum and Cockayne syndrome: overlapping clinical and biochemical phenotypes.

1992 • 164 citations

UV-induced extracellular factor from human fibroblasts communicates the UV response to nonirradiated cells

1984 • 162 citations

ACTIVATION OF NF‐KB IN HUMAN SKIN FIBROBLASTS BY THE OXIDATIVE STRESS GENERATED BY UVA RADIATION

1995 • 155 citations

Biological Responses to Ultraviolet A Radiation

1992 • 153 citations

Structure and Function of Transcription-Repair Coupling Factor

1995 • 152 citations

ZAP-70 tyrosine kinase, CD45, and T cell receptor involvement in UV- and H2O2-induced T cell signal transduction.

1994 • 150 citations

Where transcription meets repair

1994 • 148 citations

Trichothiodystrophy: Review of sulfur-deficient brittle hair syndromes and association with the ectodermal dysplasias

1990 • 143 citations

DNA damage enhances melanogenesis

1996 • 139 citations

Molecular cloning of a mouse DNA repair gene that complements the defect of group-A xeroderma pigmentosum.

1989 • 137 citations

Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain.

1996 • 134 citations

DNA replication and mutagenesis

1988 • 131 citations

ULTRAVIOLET‐RADIATION INDUCED c‐jun GENE TRANSCRIPTION: TWO AP‐1 LIKE BINDING SITES MEDIATE THE RESPONSE

1992 • 129 citations

In vivo protein-DNA interactions at the c-jun promoter: preformed complexes mediate the UV response.

1993 • 128 citations

Intramolecular signal transduction in c-Jun.

1995 • 127 citations

Identification of MAP Kinase Domains by Redirecting Stress Signals into Growth Factor Responses

1996 • 127 citations

UV irradiation-induced interleukin-1 and basic fibroblast growth factor synthesis and release mediate part of the UV response.

1993 • 126 citations

Effects of H2O2 on protein tyrosine phosphatase activity in HER14 cells

1994 • 121 citations

Genotoxic stress confers preferential and coordinate messenger RNA stability on the five gadd genes.

1994 • 120 citations

UV-induced transcription from the human immunodeficiency virus type 1 (HIV-1) long terminal repeat and UV-induced secretion of an extracellular factor that induces HIV-1 transcription in nonirradiated cells

1989 • 119 citations

Molecular cloning of the human DNA excision repair gene ERCC-6.

1990 • 119 citations

Genetic heterogeneity of the excision repair defect associated with trichothiodystrophy

1993 • 117 citations

DNA repair domains within a human gene: selective repair of sequences near the transcription initiation site.

1996 • 116 citations

Metallothionein null cells have increased sensitivity to anticancer drugs.

1995 • 116 citations

Effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate- and ultraviolet B light-induced expression of c-Jun and c-Fos in JB6 cells and in mouse epidermis

1994 • 115 citations

Trichothiodystrophy, a human DNA repair disorder with heterogeneity in the cellular response to ultraviolet light.

1988 • 104 citations

Binding of promoter-associated AP-1 is not altered during induction and subsequent repression of the c-jun promoter by TPA and UV irradiation

1994 • 97 citations

Overexpressed human metallothionein IIA gene protects Chinese hamster ovary cells from killing by alkylating agents.

1990 • 96 citations

Induction of plasminogen activator by UV light in normal and xeroderma pigmentosum fibroblasts.

1981 • 96 citations

ULTRAVIOLET SUNLIGHT REACHING THE EARTH'S SURFACE: A REVIEW OF RECENT RESEARCH

1993 • 96 citations

Activation of Src-like p56/p53lyn tyrosine kinase by ionizing radiation.

1994 • 95 citations

The mammalian UV response: Mechanism of DNA damage induced gene expression

1994 • 94 citations

Ultraviolet B light induces G1 arrest in human melanocytes by prolonged inhibition of retinoblastoma protein phosphorylation associated with long-term expression of the p21Waf-1/SDI-1/Cip-1 protein.

1995 • 93 citations

Different removal of ultraviolet photoproducts in genetically related xeroderma pigmentosum and trichothiodystrophy diseases.

1995 • 91 citations

Inducible cellular responses to ultraviolet light irradiation and other mediators of DNA damage in mammalian cells

1990 • 88 citations

The FOS and JUN Families of Transcription Factors

2017 • 86 citations

UVB radiation induces p21Cip1/WAF1 and mediates G1 and S phase checkpoints.

1996 • 77 citations

Phenotypic alterations in fos-transgenic mice correlate with changes in Fos/Jun-dependent collagenase type I expression. Regulation of mouse metalloproteinases by carcinogens, tumor promoters, cAMP, and Fos oncoprotein.

1994 • 77 citations

Relationship between pyrimidine dimers, 6-4 photoproducts, repair synthesis and cell survival: Studies using cells from patients with trichothiodystrophy

1990 • 76 citations

Isolation of the functional human excision repair gene ERCC5 by intercosmid recombination

1990 • 76 citations

Defective induction of stress-activated protein kinase activity in ataxia-telangiectasia cells exposed to ionizing radiation.

1995 • 75 citations

ACTIVATION OF HUMAN IMMUNODEFICIENCY VIRUS BY ULTRAVIOLET RADIATION

1990 • 75 citations

The insulinomimetic agents H2O2 and vanadate stimulate tyrosine phosphorylation of potential target proteins for the insulin receptor kinase in intact cells

1992 • 75 citations

Embryonic stem (ES) cells lacking functional c-jun: consequences for growth and differentiation, AP-1 activity and tumorigenicity.

1992 • 74 citations

c-Fos is involved in the cellular defence against the genotoxic effect of UV radiation

1995 • 74 citations

DNA repair comes of age

1995 • 74 citations

The ATM gene and the radiobiology of ataxia-telangiectasia

1996 • 74 citations

ULTRAVIOLET DOSIMETRY IN OUTDOOR MEASUREMENTS BASED ON BACTERIOPHAGE T7 AS A BIOSENSOR

1994 • 73 citations

Induction of urokinase-type plasminogen activator by UV light in human fetal fibroblasts is mediated through a UV-induced secreted protein.

1987 • 69 citations

Differential regulation of c-fos, fosB, c-jun, junB, bcl-2 and bax expression in rat skin following single or chronic ultraviolet irradiation and in vivo modulation by antisense oligodeoxynucleotide superfusion.

1994 • 63 citations

Involvement of a Putative Protein-tyrosine Phosphatase and IκB-α Serine Phosphorylation in Nuclear Factor κB Activation by Tumor Necrosis Factor

1995 • 60 citations

Ultraviolet radiation induces phosphorylation of the epidermal growth factor receptor.

1994 • 58 citations

Damage to DNA by UV light and activation of transcription factors

1994 • 56 citations

Activation of the pp90rsk and mitogen-activated serine/threonine protein kinases by ionizing radiation.

1994 • 53 citations

Mechanism of induction of c-fos by ultraviolet B (290-320 nm) in mouse JB6 epidermal cells.

1993 • 53 citations

Transcriptional and post-transcriptional responses to DNA-damaging agents

1994 • 51 citations

DNA replication and mutagenesis

1988 • 48 citations

Mechanisms of the ultraviolet light response in mammalian cells*

1989 • 45 citations

A new cAMP response element in the transcribed region of the human c-fos gene

1991 • 42 citations

Cyclobutane Pyrimidine Dimers in UV-DNA Induce Release of Soluble Mediators that Activate the Human Immunodeficiency Virus Promoter

1993 • 39 citations

The Role of Intracellular Calcium in the Cellular Response to Ionizing Radiation

1994 • 34 citations

12-O-tetradecanoylphorbol 13-acetate-inducible proteins are synthesized at an increased rate in Bloom syndrome fibroblasts.

1982 • 34 citations

A B-lymphocyte-specific high-turnover protein: Constitutive expression in resting B cells and induction of synthesis in proliferating cells

1982 • 32 citations

ET-18-OCH3 inhibits nuclear factor-kappa B activation by 12-O-tetradecanoylphorbol-13-acetate but not by tumor necrosis factor-alpha or interleukin 1 alpha.

1995 • 32 citations

REGULATION and INHIBITION OF COLLAGENASE EXPRESSION BY LONG-WAVELENGTH ULTRAVIOLET RADIATION IN CULTURED HUMAN SKIN FIBROBLASTS

1995 • 31 citations

Membrane-derived second messenger regulates x-ray-mediated tumor necrosis factor alpha gene induction.

1994 • 30 citations

Ras-independent activation of Rel-family transcription factors by UVB and TPA in cultured keratinocytes.

1996 • 27 citations

The mammalian cell as a microorganism;: Genetic and biochemical studies in vitro

1972 • 26 citations

UV‐responsive element (TGACAACA) from rat fibroblasts to human melanomas

1994 • 22 citations

The Mammalian Cell as a Micro-organism: Genetic and Biochemical Studies in vitro

1973 • 21 citations

A synthetic hapten for induction of thymine‐dimer‐specific antibodies

1984 • 20 citations

DNA damaging agents and growth factors induce changes in the program of expressed gene products through common routes

1994 • 20 citations

Pyrimidine dimer formation by UVA radiation: Implications for photoreactivation

1991 • 18 citations

A possible factor in genetic instability of cancer cells: stress-induced secreted proteins lead to decrease in replication fidelity

1992 • 18 citations

Supernatant medium from UV-irradiated cells influences the cytotoxicity and mutagenicity of V79 cells

1995 • 16 citations

Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation

1996 • 13 citations

Induced Effects of Genotoxic Agents in Eukaryotic Cells

1993 • 8 citations

The cAMP responsive element binding protein (CREB) as a participant in the mammalian UVC response and as a target for repression by the activated glucocorticoid receptor

1996 • 2 citations