The insulinomimetic agents H2O2 and vanadate stimulate tyrosine phosphorylation of potential target proteins for the insulin receptor kinase in intact cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

1986 • 1,100 citations

A thousand and one protein kinases

1987 • 1,066 citations

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

1988 • 1,032 citations

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

1989 • 978 citations

After Insulin Binds

1987 • 687 citations

Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

1987 • 670 citations

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

1985 • 665 citations

Insulin-like stimulation of glucose oxidation in rat adipocytes by vanadyl (IV) ions

1980 • 556 citations

Characterization of the major protein-tyrosine-phosphatases of human placenta.

1988 • 554 citations

Activation of phosphatidylinositol 3-kinase by insulin.

1990 • 531 citations

The insulinomimetic agents H2O2 and vanadate stimulate protein tyrosine phosphorylation in intact cells.

1990 • 440 citations

The insulin-mimetic effects of vanadate in isolated rat adipocytes. Dissociation from effects of vanadate as a (Na+-K+)ATPase inhibitor.

1980 • 392 citations

A novel mechanism for the insulin-like effect of vanadate on glycogen synthase in rat adipocytes.

1984 • 351 citations

Transformation of cells by an inhibitor of phosphatases acting on phosphotyrosine in proteins

1985 • 331 citations

Pervanadate [peroxide(s) of vanadate] mimics insulin action in rat adipocytes via activation of the insulin receptor tyrosine kinase

1989 • 317 citations

Protein-tyrosine phosphatases: The other side of the coin

1989 • 308 citations

Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation

1987 • 307 citations

Phosphatidylinositol kinase or an associated protein is a substrate for the insulin receptor tyrosine kinase.

1990 • 266 citations

Evidence for the Involvement of Sulfhydryl Oxidation in the Regulation of Fat Cell Hexose Transport by Insulin

1974 • 209 citations

Purification and partial sequence analysis of pp185, the major cellular substrate of the insulin receptor tyrosine kinase

1991 • 198 citations

The insulin-like effect of hydrogen peroxide on pathways of lipid synthesis in rat adipocytes.

1979 • 196 citations

Insulin-activated tyrosine phosphorylation of a 15-kilodalton protein in intact 3T3-L1 adipocytes.

1987 • 181 citations

Peroxide(s) of vanadium : A novel and potent insulin-mimetic agent which activates the insulin receptor kinase

1987 • 177 citations

Modulation of intercellular adherens-type junctions and tyrosine phosphorylation of their components in RSV-transformed cultured chick lens cells.

1991 • 164 citations

Role of insulin receptor phosphorylation in the insulinomimetic effects of hydrogen peroxide.

1987 • 156 citations

Stimulation of insulin-like growth factor II receptor binding and insulin receptor kinase activity in rat adipocytes. Effects of vanadate and H2O2.

1987 • 148 citations

Activation of glycogen synthase in rat adipocytes by insulin and glucose involves increased glucose transport and phosphorylation.

1978 • 142 citations

Hydrogen peroxide stimulates tyrosine phosphorylation of the insulin receptor and its tyrosine kinase activity in intact cells

1988 • 120 citations

Insulin and insulin-like growth factor-I stimulate a common endogenous phosphoprotein substrate (pp185) in intact neuroblastoma cells.

1987 • 120 citations

A combination of hydrogen peroxide and vanadate concomitantly stimulates protein tyrosine phosphorylation and polyphosphoinositide breakdown in different cell lines

1990 • 106 citations

Insulin rapidly stimulates phosphorylation of a 46-kDa membrane protein on tyrosine residues as well as phosphorylation of several soluble proteins in intact fat cells.

1987 • 97 citations

The Insulin Receptor: Structure and Functio

1989 • 90 citations

H2O2 potentiates phosphorylation of novel putative substrates for the insulin receptor kinase in intact Fao cells

1989 • 89 citations

Insulin stimulates phosphorylation of a 120-kDa glycoprotein substrate (pp120) for the receptor-associated protein kinase in intact H-35 hepatoma cells.

1987 • 84 citations

Effects of hydrogen peroxide on basal and hormone-stimulated lipolysis in perifused rat fat cells in relation to the mechanism of action of insulin.

1980 • 73 citations

Insulin stimulates the phosphorylation of calmodulin in intact adipocytes.

1987 • 70 citations

Control of muscle differentiation in BC3H1 cells by fibroblast growth factor and vanadate.

1987 • 70 citations

Insulin's regulation of c-fos gene transcription in hepatoma cells.

1990 • 66 citations

Characterization of the phosphotyrosyl protein phosphatase activity of calmodulin-dependent protein phosphatase.

1986 • 65 citations

Insulin-mimetic anti-insulin receptor monoclonal antibodies stimulate receptor kinase activity in intact cells.

1990 • 48 citations

Vanadate down-regulates cell surface insulin and growth hormone receptors and inhibits insulin receptor degradation in cultured human lymphocytes.

1988 • 46 citations

Insulin stimulates a membrane-bound serine kinase that may be phosphorylated on tyrosine.

1987 • 37 citations

Vanadate stimulation of IGF binding to rat adipocytes

1986 • 29 citations

pp75: A novel tyrosine-phosphorylated protein that heralds differentiation of HL-60 cells

1991 • 17 citations

Insulin-stimulated protein biosynthesis as a paradigm of protein kinase C-independent growth factor action.

1989 • 11 citations

Insulin-stimulated protein biosynthesis as a paradigm of protein kinase C-independent growth factor action.

1989 • 10 citations

Polylysine increases the number of insulin binding sites in soluble insulin receptor preparations.

1991 • 8 citations