Membrane-derived second messenger regulates x-ray-mediated tumor necrosis factor alpha gene induction.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Protein Kinase C Contains a Pseudosubstrate Prototope in Its Regulatory Domain

1987 • 1,020 citations

A Potential Second Messenger Role for Unsaturated Fatty Acids: Activation of Ca ²⁺ -Dependent Protein Kinase

1984 • 618 citations

Increased serum levels of tumor necrosis factor alpha precede major complications of bone marrow transplantation [see comments]

1990 • 591 citations

INDUCIBLE DNA REPAIR SYSTEMS

1985 • 586 citations

Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxofylline

1988 • 564 citations

Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway.

1990 • 509 citations

Increased tumor necrosis factor alpha mRNA after cellular exposure to ionizing radiation.

1989 • 473 citations

Fission yeast genes involved in coupling mitosis to completion of DNA replication.

1992 • 382 citations

Protein kinase C activation by cis-fatty acid in the absence of Ca2+ and phospholipids.

1986 • 309 citations

A synthetic peptide substrate for selective assay of protein kinase C

1990 • 292 citations

Protein kinase C mediates x-ray inducibility of nuclear signal transducers EGR1 and JUN.

1991 • 277 citations

Modification of radiation injury to normal tissues by chemotherapeutic agents

1975 • 273 citations

Epidermal growth factor—induced actin remodeling is regulated by 5-lipoxygenase and cyclooxygenase products

1993 • 255 citations

The influence of phospholipase A2 and glutathione peroxidase on the elimination of membrane lipid peroxides

1983 • 235 citations

Kinetic analysis of 1,2-diacylglycerol mass levels in cultured fibroblasts. Comparison of stimulation by alpha-thrombin and epidermal growth factor.

1988 • 207 citations

Phase I-II trial of pentoxifylline for the prevention of transplant- related toxicities following bone marrow transplantation [published erratum appears in Blood 1992 Jun 15;79(12):3397] [see comments]

1991 • 200 citations

Ionizing radiation stimulates unidentified tyrosine-specific protein kinases in human B-lymphocyte precursors, triggering apoptosis and clonogenic cell death.

1992 • 195 citations

DNA damage-induced gene expression: Signal transduction and relation to growth factor signaling

1992 • 187 citations

Involvement of reactive oxygen intermediates in the induction of c-jun gene transcription by ionizing radiation

1992 • 161 citations

Regulation of tumor necrosis factor gene expression by ionizing radiation in human myeloid leukemia cells and peripheral blood monocytes.

1991 • 148 citations

Tumor necrosis factor gene expression is mediated by protein kinase C following activation by ionizing radiation.

1991 • 138 citations

Regulation of RAD54- and RAD52-lacZ gene fusions in Saccharomyces cerevisiae in response to DNA damage.

1987 • 137 citations

Hydrogen peroxide-induced c-fos expression is mediated by arachidonic acid release: role of protein kinase C

1993 • 137 citations

Isolation of crt mutants constitutive for transcription of the DNA damage inducible gene RNR3 in Saccharomyces cerevisiae.

1992 • 127 citations

Role of cytokines (interleukin 1, tumor necrosis factor, and transforming growth factor beta) in natural and lipopolysaccharide-enhanced radioresistance.

1991 • 118 citations

Recombinant tumor necrosis factor and intepleukin-1 both stimulate human synovial cell arachidonic acid release and phospholipid metabolism

1987 • 110 citations

[25] Mixed micelle assay of protein kinase C

1986 • 102 citations

Inhibition of Protein Kinases Sensitizes Human Tumor Cells to Ionizing Radiation

1992 • 91 citations

Arachidonic acid and diacylglycerol act synergistically to activate protein kinase C in vitro and in vivo

1991 • 88 citations

Differential activation of protein kinase C alpha is associated with arachidonate release in Madin-Darby canine kidney cells.

1990 • 85 citations

Stimulation of phospholipase A₂ activity by oxygen‐derived free radicals in isolated brain capillaries

1985 • 73 citations

Phospholipase A2 activation and autoinduction of tumor necrosis factor gene expression by tumor necrosis factor.

1990 • 73 citations

Oxidants and conductance of cultured epithelial cell monolayers: inositol phospholipid hydrolysis

1988 • 62 citations

Radiation pneumonitis in mice. Some effects of corticosteroids on mortality and pulmonary physiology.

1980 • 54 citations

The Effect of Steroids on Radiation-Induced Lung Disease in the Rat

1993 • 53 citations

Transcript levels of theSaccharomyces cerevisiaeDNA repair gene RAD18 increase in UV irradiated cells and during meiosis but not during the mitotic cell cycle

1991 • 51 citations

The Pulmonary Response to Sublethal Thoracic Irradiation in the Rat

1993 • 49 citations

The influence of gamma radiation on arachidonic acid release and prostacyclin synthesis

1983 • 47 citations

Influence of Unsaturated Fatty Acids, Membrane Fluidity and Oxygenation on the Survival of anE. ColiFatty Acid Auxotroph Following γ-irradiation

1979 • 43 citations

Regulation of RAD54- and RAD52-lacZ Gene Fusions in Saccharomyces cerevisiae in Response to DNA Damage

1987 • 38 citations

Basal activation of protein kinase C in rat alveolar macrophages: implications for arachidonate metabolism

1991 • 34 citations

Arachidonic acid and related methyl ester mediate protein kinase C activation in intact platelets through the arachidonate metabolism pathways

1990 • 32 citations

Arachidonic andcis‐unsaturated fatty acids induce selective platelet substrate phosphorylation through activation of cytosolic protein kinase C

1991 • 30 citations

EFfects of two methylxanthines, pentoxifylline and propentofylline, on arachidonic acid metabolism in platelets stimulated by thrombin

1988 • 24 citations

Hydrogen Peroxide Stimulates Phospholipase A₂-Mediated Arachidonic Acid Release in Cultured Intestinal Epithelial Cells (INT 407)

1991 • 18 citations

Differential dependence on protein kinase C of arachidonic acid metabolism stimulated by hydrogen peroxide and by zymosan in the alveolar macrophage

1990 • 17 citations

Arachidonic metabolism and radiation toxicity in cultures of vascular endothelial cells

1989 • 14 citations

Influence of whole-body gamma irradiation upon arachidonic acid metabolism in rat platelets

1985 • 9 citations