Overexpressed human metallothionein IIA gene protects Chinese hamster ovary cells from killing by alkylating agents.

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Selective extraction of polyoma DNA from infected mouse cell cultures

1967 • 5,357 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).

1979 • 1,680 citations

METALLOTHIONEIN

1986 • 1,606 citations

DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.

1979 • 1,339 citations

Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals

1985 • 1,042 citations

Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene

1984 • 955 citations

Overexpression of Metallothionein Confers Resistance to Anticancer Drugs

1988 • 600 citations

Metallothioneins: Proteins in search of function

1985 • 445 citations

DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells

1980 • 315 citations

Amplification of the metallothionein-I gene in cadmium-resistant mouse cells.

1981 • 314 citations

Formation and Metabolism of Alkylated Nucleosides: Possible Role in Carcinogenesis by Nitroso Compounds and Alkylating Agents

1977 • 304 citations

Transcriptional regulation of mouse liver metallothionein-I gene by glucocorticoids

1981 • 284 citations

Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA

1979 • 260 citations

Cellular Radiobiology

1980 • 256 citations

Sites and structure of gamma radiation-induced DNA strand breaks.

1982 • 249 citations

Induction of metallothionein and other mRNA species by carcinogens and tumor promoters in primary human skin fibroblasts.

1986 • 215 citations

Interleukin 1 regulates human metallothionein gene expression.

1985 • 185 citations

Metallothionein-mediated cisplatin resistance in human ovarian carcinoma cells

1987 • 175 citations

Resistance against cis-dichlorodiammineplatinum in cultured cells with a high content of metallothionein

1981 • 168 citations

Reduction of the toxicity and mutagenicity of alkylating agents in mammalian cells harboring the Escherichia coli alkyltransferase gene.

1986 • 125 citations

Suppression of human DNA alkylation-repair defects by Escherichia coli DNA-repair genes.

1986 • 115 citations

A stable bovine papillomavirus hybrid plasmid that expresses a dominant selective trait.

1983 • 113 citations

Radioresistance in cells with high content of metallothionein

1982 • 112 citations

A simplified assay for O⁶-methylguanine-DNA methyltransferase activity and its application to human neoplastic and non-neoplastic tissues

1984 • 104 citations

Expression and regulation of a human metallothionein gene carried on an autonomously replicating shuttle vector.

1983 • 94 citations

Complementation of sensitivity to alkylating agents in Escherichia coli and Chinese hamster ovary cells by expression of a cloned bacterial DNA repair gene.

1986 • 82 citations

The mammalian genetic stress response

1986 • 79 citations

Metallothionein Induction as a Potent Means of Radiation Protection in Mice

1987 • 71 citations

Transfer of the E. coli O6-methyltransferase gene into repair-deficient human cells and restoration of cellular resistance to N-methyl-N′-nitro-N-nitrosoguanidine

1986 • 67 citations

Characterization of the Metallothioneins Induced in HeLa Cells by Dexamethasone and Zinc

1980 • 67 citations

Binding of cis-dichlorodiammine platinum(II) to metallothionein in Ehrlich cells

1985 • 64 citations

Promotion of radioresistance by metallothionein induction prior to irradiation

1987 • 58 citations

The application of the microbial “tooth-pick” technique to somatic cell genetics, and its use in the isolation of X-ray sensitive mutants of chinese hamster ovary cells

1982 • 52 citations

Induction of Metallothionein and Other mRNA Species by Carcinogens and Tumor Promoters in Primary Human Skin Fibroblasts

1986 • 50 citations

Mechanisms of the ultraviolet light response in mammalian cells*

1989 • 45 citations

Growth factors, tumor promoters and cancer genes

1986 • 43 citations

Multiple transcripts of T-DNA detected in nopaline crown gall tumors.

1982 • 43 citations

A Stable Bovine Papillomavirus Hybrid Plasmid That Expresses a Dominant Selective Trait

1983 • 40 citations

Dependency of the yield of sister-chromatid exchanges induced by alkylating agents on fixation time

1985 • 36 citations

Determination of Cd-thionein in biological materials: Comparative standard recovery by five current methods using protein nitrogen for standard calibration

1986 • 32 citations

Interleukin 1 Regulates Human Metallothionein Gene Expression

1985 • 24 citations

Influence of Buthionine Sulfoximine and Misonidazole on Glutathione Level and Radiosensitivity of Human Tumor Xenografts

1986 • 22 citations

Transfer of human genes conferring resistance to methylating mutagens, but not to UV irradiation and cross-linking agents, into Chinese hamster ovary cells.

1987 • 21 citations