Interruption of the NF-κB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

1984 • 6,841 citations

A Phase 2 Study of Bortezomib in Relapsed, Refractory Myeloma

2003 • 2,642 citations

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

2001 • 2,488 citations

NF-κB in cancer: from innocent bystander to major culprit

2002 • 2,457 citations

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

1997 • 1,802 citations

Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway

2000 • 1,703 citations

Novel Inhibitors of Cytokine-induced IκBα Phosphorylation and Endothelial Cell Adhesion Molecule Expression Show Anti-inflammatory Effects in Vivo

1997 • 1,045 citations

BCL-2 Is Phosphorylated and Inactivated by an ASK1/Jun N-Terminal Protein Kinase Pathway Normally Activated at G₂/M

1999 • 997 citations

NF-κB as a Therapeutic Target in Multiple Myeloma

2002 • 906 citations

Cell Adhesion Mediated Drug Resistance (CAM-DR): Role of Integrins and Resistance to Apoptosis in Human Myeloma Cell Lines

1999 • 850 citations

Multiple Myeloma: Increasing Evidence for a Multistep Transformation Process

1998 • 761 citations

The Rel/NF-κB Family Directly Activates Expression of the Apoptosis Inhibitor Bcl-x_L

2000 • 747 citations

Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling

2001 • 725 citations

Inhibition of JNK activation through NF-κB target genes

2001 • 720 citations

Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor–κB and IκBα kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis

2003 • 678 citations

A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia

2003 • 656 citations

Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341

2003 • 572 citations

NF-κB as a therapeutic target in cancer

2002 • 550 citations

The Chk1 Protein Kinase and the Cdc25C Regulatory Pathways Are Targets of the Anticancer Agent UCN-01

2000 • 548 citations

Inhibition of NF-κB Activity by Thalidomide through Suppression of IκB Kinase Activity

2001 • 477 citations

Caspase-3-dependent Cleavage of Bcl-2 Promotes Release of Cytochrome c

1999 • 461 citations

Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2

2001 • 430 citations

Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-xL is an essential survival protein of human myeloma cells

2002 • 420 citations

Biologic sequelae of nuclear factor–κB blockade in multiple myeloma: therapeutic applications

2002 • 382 citations

Inhibition of Constitutive NF-κB Activation in Mantle Cell Lymphoma B Cells Leads to Induction of Cell Cycle Arrest and Apoptosis

2003 • 325 citations

Inhibition of NF-κB induces apoptosis of KSHV-infected primary effusion lymphoma cells

2000 • 307 citations

ICE-LAP6, a Novel Member of the ICE/Ced-3 Gene Family, Is Activated by the Cytotoxic T Cell Protease Granzyme B

1996 • 304 citations

Phase I Trial of 72-Hour Continuous Infusion UCN-01 in Patients With Refractory Neoplasms

2001 • 295 citations

Paclitaxel sensitivity of breast cancer cells with constitutively active NF-κB is enhanced by IκBα super-repressor and parthenolide

2000 • 290 citations

Bay 11-7082 inhibits transcription factor NF-kappa B and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells

2002 • 276 citations

Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia

2000 • 258 citations

Caspase-8 Activation and Bid Cleavage Contribute to MCF7 Cellular Execution in a Caspase-3-dependent Manner during Staurosporine-mediated Apoptosis

2000 • 248 citations

Activation of NF-kappa B requires proteolysis of the inhibitor I kappa B-alpha: signal-induced phosphorylation of I kappa B-alpha alone does not release active NF-kappa B.

1995 • 243 citations

Phosphorylation and Inactivation of Myeloid Cell Leukemia 1 by JNK in Response to Oxidative Stress

2002 • 218 citations

A review of the cytokine network in multiple myeloma

2003 • 218 citations

Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine)

2002 • 210 citations

Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia

2000 • 193 citations

The AKT kinase is activated in multiple myeloma tumor cells

2001 • 193 citations

Cell adhesion-mediated drug resistance (CAM-DR) is associated with activation of NF-κB (RelB/p50) in myeloma cells

2003 • 183 citations

NF-κB activates Bcl-2 expression in t(14;18) lymphoma cells

2002 • 182 citations

Rapid Kinetics of tBid-induced Cytochrome c and Smac/DIABLO Release and Mitochondrial Depolarization

2002 • 180 citations

Proteasome inhibition in cancer: Development of PS-341

2001 • 178 citations

Pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase/MAPK cascade interact synergistically with UCN-01 to induce mitochondrial dysfunction and apoptosis in human leukemia cells.

2001 • 162 citations

Inhibition of NF-κB essentially contributes to arsenic-induced apoptosis

2003 • 156 citations

Insulin-like growth factor induces the survival and proliferation of myeloma cells through an interleukin-6-independent transduction pathway

2000 • 154 citations

IκBα Functions through Direct Contacts with the Nuclear Localization Signals and the DNA Binding Sequences of NF-κB

1998 • 151 citations

A major role for Mcl-1 antiapoptotic protein in the IL-6-induced survival of human myeloma cells

2003 • 148 citations

Multicenter phase 2 trial of thalidomide in relapsed/refractory multiple myeloma: adverse prognostic impact of advanced age

2003 • 132 citations

Targeting p38 MAPK inhibits multiple myeloma cell growth in the bone marrow milieu

2002 • 120 citations

The role of nuclear factor-?b in the biology and treatment of multiple myeloma

2001 • 119 citations

A mechanism of resistance to glucocorticoids in multiple myeloma: transient expression of a truncated glucocorticoid receptor mRNA

1992 • 114 citations

The Cell Cycle as a Target for Cancer Therapy: Basic and Clinical Findings with the Small Molecule Inhibitors Flavopiridol and UCN-01

2002 • 109 citations

Rapid Tumor Formation of Human T-Cell Leukemia Virus Type 1-Infected Cell Lines in Novel NOD-SCID/γc^nullMice: Suppression by an Inhibitor against NF-κB

2003 • 108 citations

Diagnosis and management of multiple myeloma

2001 • 101 citations

Combined treatment with the checkpoint abrogator UCN-01 and MEK1/2 inhibitors potently induces apoptosis in drug-sensitive and -resistant myeloma cells through an IL-6–independent mechanism

2002 • 94 citations

7-Hydroxystaurosporine (UCN-01) Induces Apoptosis in Human Colon Carcinoma and Leukemia Cells Independently of p53

1997 • 89 citations

UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G2 checkpoint abrogation

2000 • 89 citations

Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways

2003 • 85 citations

UCN‐01, an anti‐tumor drug, is a selective inhibitor of the conventional PKC subfamily

1995 • 78 citations

NF-κB–mediated chemoresistance in breast cancer cells

2001 • 76 citations

A mechanism of resistance to glucocorticoids in multiple myeloma: transient expression of a truncated glucocorticoid receptor mRNA

1992 • 74 citations

Functional cooperation between JunD and NF-κB in rat hepatocytes

2001 • 40 citations

Potentiation of 1-β-d-arabinofuranosylcytosine-mediated mitochondrial damage and apoptosis in human leukemia cells (U937) overexpressing Bcl-2 by the kinase inhibitor 7-hydroxystaurosporine (UCN-01)

2000 • 39 citations

Bryostatin 1 and UCN-01 Potentiate 1-β-d-Arabinofuranosylcytosine-Induced Apoptosis in Human Myeloid Leukemia Cells through Disparate Mechanisms

2003 • 25 citations

Analysis of IL-6-mediated growth control of myeloma cells using a gp130 chimeric receptor approach

2002 • 18 citations

Deregulation of Cdc2 kinase induces caspase-3 activation and apoptosis

2003 • 17 citations

Multiple myeloma: role of allogeneic transplantation.

2002 • 3 citations