Biologic sequelae of nuclear factor–κB blockade in multiple myeloma: therapeutic applications

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation

1998 • 2,698 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

1995 • 2,386 citations

An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9

1999 • 2,088 citations

The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.

2001 • 1,520 citations

Bax directly induces release of cytochrome c from isolated mitochondria

1998 • 1,514 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

Aberrant rel/nfkb genes and activity in human cancer

1999 • 1,127 citations

Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB

1999 • 1,001 citations

Inhibition of Nuclear Translocation of Transcription Factor NF-κB by a Synthetic Peptide Containing a Cell Membrane-permeable Motif and Nuclear Localization Sequence

1995 • 923 citations

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control

1997 • 875 citations

Constitutive Activation of NF-κB during Progression of Breast Cancer to Hormone-Independent Growth

1997 • 824 citations

Akt Stimulates the Transactivation Potential of the RelA/p65 Subunit of NF-κB through Utilization of the IκB Kinase and Activation of the Mitogen-activated Protein Kinase p38

2001 • 774 citations

Multiple Myeloma: Increasing Evidence for a Multistep Transformation Process

1998 • 761 citations

Nuclear factor-κB is constitutively activated in primitive human acute myelogenous leukemia cells

2001 • 732 citations

The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappa B that blocks TNFalpha -induced apoptosis

1999 • 721 citations

Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications

2002 • 670 citations

An Anti-apoptotic Protein Human Survivin Is a Direct Inhibitor of Caspase-3 and -7

2001 • 670 citations

Nuclear Factor (NF)-κB–regulated X-chromosome–linked iap Gene Expression Protects Endothelial Cells from Tumor Necrosis Factor α–induced Apoptosis

1998 • 643 citations

Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells.

1996 • 604 citations

NF-κB Induces Expression of the Bcl-2 Homologue A1/Bfl-1 To Preferentially Suppress Chemotherapy-Induced Apoptosis

1999 • 574 citations

Tumor Necrosis Factor Induces Bcl-2 and Bcl-x Expression through NFκB Activation in Primary Hippocampal Neurons

1999 • 552 citations

The Rel/NF-κB signal transduction pathway: introduction

1999 • 436 citations

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

1999 • 410 citations

Constitutive NF-kB Activity in Neurons

1994 • 400 citations

The role of tumor necrosis factor α in the pathophysiology of human multiple myeloma: therapeutic applications

2001 • 398 citations

TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications

2001 • 397 citations

TNF-α stimulates activation of pro-MMP2 in human skin through NF-κB mediated induction of MT1-MMP

2001 • 395 citations

Multiple Myeloma

1997 • 389 citations

Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IκBα

1999 • 347 citations

Constitutive NF-kappa B activity in neurons.

1994 • 304 citations

Molecular mechanisms of constitutive NF-κB/Rel activation in Hodgkin/Reed-Sternberg cells

1999 • 285 citations

Induction of Apoptosis by SB202190 through Inhibition of p38β Mitogen-activated Protein Kinase

1998 • 281 citations

B Lymphocytes Differentially Use the Rel and Nuclear Factor κB1 (NF-κB1) Transcription Factors to Regulate Cell Cycle Progression and Apoptosis in Quiescent and Mitogen-activated Cells

1998 • 250 citations

Nuclear factor kappaB nuclear translocation upregulates c-Myc and p53 expression during NMDA receptor-mediated apoptosis in rat striatum.

1999 • 234 citations

The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression

2000 • 226 citations

Inhibition of Nuclear Factor κB Activation Attenuates Apoptosis Resistance in Lymphoid Cells

1998 • 225 citations

A Dual Mechanism Mediates Repression of NF-κB Activity by Glucocorticoids

1998 • 225 citations

Tumor Cell Expression of CD59 Is Associated With Resistance to CD20 Serotherapy in Patients With B-Cell Malignancies

2001 • 209 citations

Nuclear Factor κB Nuclear Translocation Upregulates c-Myc and p53 Expression during NMDA Receptor-Mediated Apoptosis in Rat Striatum

1999 • 206 citations

Nuclear Factor-κB Contributes to Excitotoxin-Induced Apoptosis in Rat Striatum

1998 • 167 citations

Intracellular regulation of tumor necrosis factor–related apoptosis-inducing ligand–induced apoptosis in human multiple myeloma cells

2002 • 155 citations

Macrophages Require Constitutive NF-κB Activation To Maintain A1 Expression and Mitochondrial Homeostasis

2000 • 153 citations

Photo-oxidative Stress Down-modulates the Activity of Nuclear Factor-κB via Involvement of Caspase-1, Leading to Apoptosis of Photoreceptor Cells

1999 • 133 citations

Muc-1 Core Protein Is Expressed on Multiple Myeloma Cells and Is Induced by Dexamethasone

1999 • 129 citations

NF-κB1 (p50) Homodimers Contribute to Transcription of thebcl-2 Oncogene

2001 • 116 citations

Inhibition of NF-kappa B activity in human T lymphocytes induces caspase-dependent apoptosis without detectable activation of caspase-1 and -3.

1999 • 105 citations

Stage-Specific Nuclear Expression of NF-κB in Mammalian Testis

1998 • 99 citations

Inhibition of NF-κB Activity in Human T Lymphocytes Induces Caspase-Dependent Apoptosis Without Detectable Activation of Caspase-1 and -3

1999 • 84 citations

Fas Ligand Is Present in Tumors of the Ewing's Sarcoma Family and Is Cleaved into a Soluble Form by a Metalloproteinase

1998 • 84 citations

Nuclear Factor-κB-Mediated X-Linked Inhibitor of Apoptosis Protein Expression Prevents Rat Granulosa Cells from Tumor Necrosis Factor α-Induced Apoptosis

2001 • 82 citations

Fas-mediated apoptosis in neuroblastoma requires mitochondrial activation and is inhibited by FLICE inhibitor protein and Bcl-2.

2001 • 80 citations

Glucocorticoid-Induced Apoptosis and Regulation of NF-κB Activity in Human Leukemic T Cells*

1998 • 75 citations

Luteinizing Hormone-Releasing Hormone Induces Nuclear Factorκ B-Activation and Inhibits Apoptosis in Ovarian Cancer Cells

2000 • 72 citations

An intact NF-κB signaling pathway is required for maintenance of mature B cell subsets

1999 • 67 citations

Induction of TNFalpha in macrophages by vanadate is dependent on activation of transcription factor NF-kappaB and free radical reactions.

1999 • 47 citations

Advances in the biology of multiple myeloma: therapeutic applications.

1999 • 42 citations

Constitutive nuclear translocation of NF-kappa B in B cells in the absence of I kappa B degradation.

1999 • 41 citations

Leukemia stem cells and constitutive activation of NF-κB

2001 • 41 citations

Constitutive Nuclear Translocation of NF-κB in B Cells in the Absence of IκB Degradation

1999 • 34 citations

Constitutive activation of NF-kB in human thymocytes

1991 • 27 citations

Modulation of JunD·AP-1 DNA Binding Activity by AP-1-associated Factor 1 (AF-1)

1996 • 24 citations

PET screening of carotid occlusion.

2001 • 4 citations