Essential Cytoplasmic Translocation of a Cytokine Receptor–Assembled Signaling Complex

Cell Signaling by Receptor Tyrosine Kinases

2010 • 7,477 citations

Mammalian MAP kinase signalling cascades

2001 • 5,041 citations

Cell Signaling by Receptor Tyrosine Kinases

2000 • 3,570 citations

Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes

2003 • 2,545 citations

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

2001 • 2,027 citations

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 • 1,976 citations

TNF-R1 Signaling: A Beautiful Pathway

2002 • 1,860 citations

Signal transduction by tumor necrosis factor and its relatives

2001 • 1,623 citations

Regulation and Function of IKK and IKK-Related Kinases

2006 • 1,238 citations

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

1995 • 1,237 citations

The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway

1999 • 1,163 citations

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

1994 • 1,043 citations

Promiscuous Mutations Activate the Noncanonical NF-κB Pathway in Multiple Myeloma

2007 • 974 citations

Activation of IKK by TNFα Requires Site-Specific Ubiquitination of RIP1 and Polyubiquitin Binding by NEMO

2006 • 956 citations

IKK-γ is an essential regulatory subunit of the IκB kinase complex

1998 • 950 citations

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

2005 • 915 citations

The molecular architecture of the TNF superfamily

2002 • 863 citations

A Small Molecule Smac Mimic Potentiates TRAIL- and TNFα-Mediated Cell Death

2004 • 648 citations

IAPs, RINGs and ubiquitylation

2005 • 591 citations

Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-κB activation

2006 • 587 citations

Autocrine TNFα Signaling Renders Human Cancer Cells Susceptible to Smac-Mimetic-Induced Apoptosis

2007 • 562 citations

Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain

1999 • 459 citations

TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2

2002 • 453 citations

The Distinct Roles of TRAF2 and RIP in IKK Activation by TNF-R1

2000 • 429 citations

SH2 domains, interaction modules and cellular wiring

2001 • 394 citations

Life And Death Decisions

2004 • 337 citations

The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7.

2000 • 336 citations

The PHD Domain of MEKK1 Acts as an E3 Ubiquitin Ligase and Mediates Ubiquitination and Degradation of ERK1/2

2002 • 314 citations

The Inhibitor of Apoptosis, cIAP2, Functions as a Ubiquitin-Protein Ligase and Promotes in VitroMonoubiquitination of Caspases 3 and 7

2000 • 294 citations

The Structural Basis for the Recognition of Diverse Receptor Sequences by TRAF2

1999 • 277 citations

Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

2006 • 264 citations

CD40 Signaling through Tumor Necrosis Factor Receptor-associated Factors (TRAFs)

1999 • 184 citations

The multifaceted roles of TRAFs in the regulation of B-cell function

2004 • 151 citations

Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production

2006 • 104 citations

TRAF2: A Double-Edged Sword?

2005 • 78 citations