Interactions of myeloma cells with osteoclasts promote tumour expansion and bone degradation through activation of a complex signalling network and upregulation of cathepsin K, matrix metalloproteinases (MMPs) and urokinase plasminogen activator (uPA)

Osteoclast differentiation and activation

2003 • 6,172 citations

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

1999 • 1,655 citations

Regulation of matrix metalloproteinase expression in tumor invasion

1999 • 1,503 citations

Efficacy of Pamidronate in Reducing Skeletal Events in Patients with Advanced Multiple Myeloma

1996 • 1,091 citations

The Collagenolytic Activity of Cathepsin K Is Unique among Mammalian Proteinases

1998 • 631 citations

Matrix metalloproteinases in skin

1997 • 592 citations

Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment

2001 • 419 citations

Soluble receptor activator of nuclear factor κB ligand–osteoprotegerin ratio predicts survival in multiple myeloma: proposal for a novel prognostic index

2003 • 406 citations

Matrix metalloproteinases (MMP) and cathepsin K contribute differently to osteoclastic activities

2003 • 331 citations

Osteoclasts enhance myeloma cell growth and survival via cell-cell contact: a vicious cycle between bone destruction and myeloma expansion

2004 • 319 citations

Degradation of collagen in the bone‐resorbing compartment underlying the osteoclast involves both cysteine‐proteinases and matrix metalloproteinases

1992 • 286 citations

RANK ligand and osteoprotegerin in myeloma bone disease

2003 • 260 citations

Proteinases in bone resorption: obvious and less obvious roles

2000 • 222 citations

Receptor activator of nuclear factor-kappaB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo.

2003 • 216 citations

Cancer and the Microenvironment

2004 • 188 citations

Bortezomib inhibits human osteoclastogenesis

2007 • 182 citations

Osteoclastic Bone Degradation and the Role of Different Cysteine Proteinases and Matrix Metalloproteinases: Differences Between Calvaria and Long Bone

2006 • 178 citations

Signal Transducer and Activator of Transcription 3 Activation Promotes Invasive Growth of Colon Carcinomas through Matrix Metal loproteinase Induction

2007 • 133 citations

Combined disruption of both the MEK/ERK and the IL-6R/STAT3 pathways is required to induce apoptosis of multiple myeloma cells in the presence of bone marrow stromal cells

2004 • 126 citations

CXCL12 chemokine up‐regulates bone resorption and MMP‐9 release by human osteoclasts: CXCL12 levels are increased in synovial and bone tissue of rheumatoid arthritis patients

2003 • 126 citations

Human primary osteoclasts: in vitro generation and applications as pharmacological and clinical assay.

2004 • 107 citations

The Role of the Plasminogen System in Bone Resorption In Vitro

1999 • 91 citations

Interactions between insulin-like growth factor-I (IGF-I) and the system of plasminogen activators and their inhibitors in the control of IGF-binding protein-3 production and proteolysis in human osteosarcoma cells.

1994 • 84 citations

Hepatocyte Growth Factor/c-Met Signaling Promotes the Progression of Experimental Human Neuroblastomas

2004 • 79 citations

MMP-9 antisense oligodeoxynucleotide exerts an inhibitory effect on osteoclastic bone resorption by suppressing cell migration

2006 • 77 citations

Increased Bone Formation in Mice Lacking Plasminogen Activators

2003 • 75 citations

Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation

2006 • 70 citations

Expression of membrane type 1 matrix metalloproteinase in papillomavirus-positive cells: role of the human papillomavirus (HPV) 16 and HPV8 E7 gene products

2005 • 56 citations

Novel targeted drugs for the treatment of multiple myeloma: from bench to bedside

2005 • 55 citations

Multifunctional Role of Matrix Metalloproteinases in Multiple Myeloma

2004 • 48 citations

New Potential Targets for Treating Myeloma Bone Disease

2006 • 38 citations

The effects of serine proteinase inhibitors on bone resorption in vitro

2003 • 34 citations

Relationship of the plasminogen activator/plasmin cascade to osteoclast invasion and mineral resorption in explanted fetal metatarsal bones

1994 • 32 citations