Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity

Caspases: Enemies Within

1998 • 6,923 citations

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

Proliferation, cell cycle and apoptosis in cancer

2001 • 3,236 citations

Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.

1988 • 3,038 citations

X-linked IAP is a direct inhibitor of cell-death proteases

1997 • 1,961 citations

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

1998 • 1,394 citations

The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

1997 • 1,316 citations

Proteases to die for

1998 • 1,241 citations

A Serine Protease, HtrA2, Is Released from the Mitochondria and Interacts with XIAP, Inducing Cell Death

2001 • 1,106 citations

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

2001 • 987 citations

Structural basis of IAP recognition by Smac/DIABLO

2000 • 844 citations

Structural Basis for the Inhibition of Caspase-3 by XIAP

2001 • 763 citations

Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

1999 • 750 citations

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo

2002 • 739 citations

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

2000 • 625 citations

Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias.

2000 • 617 citations

A Single BIR Domain of XIAP Sufficient for Inhibiting Caspases

1998 • 611 citations

Biochemical Characteristics of Caspases-3, -6, -7, and -8

1997 • 536 citations

Target Protease Specificity of the Viral Serpin CrmA

1997 • 517 citations

Caspase-9 Can Be Activated without Proteolytic Processing

1999 • 498 citations

Identification of XAF1 as an antagonist of XIAP anti-Caspase activity

2001 • 434 citations

HBXIP functions as a cofactor of survivin in apoptosis suppression

2003 • 429 citations

Characterization of XIAP-Deficient Mice

2001 • 425 citations

The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: evidence of caspase activation and apoptosis induction

2002 • 376 citations

NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP

1999 • 339 citations

Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries.

1992 • 326 citations

Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells

2001 • 304 citations

Coexistence of high levels of apoptotic signaling and inhibitor of apoptosis proteins in human tumor cells: implication for cancer specific therapy.

2003 • 269 citations

Elevated expression of inhibitor of apoptosis proteins in prostate cancer.

2003 • 241 citations

Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptide.

2003 • 238 citations

The Survivin saga goes in vivo

2001 • 212 citations

"Libraries from libraries": chemical transformation of combinatorial libraries to extend the range and repertoire of chemical diversity.

1994 • 209 citations

Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex

2001 • 166 citations

Reprieval from execution: the molecular basis of caspase inhibition

2002 • 165 citations

Differential sensitivity of various pediatric cancers and squamous cell carcinomas to lovastatin-induced apoptosis: therapeutic implications.

2001 • 164 citations

SMAC Negatively Regulates the Anti-apoptotic Activity of Melanoma Inhibitor of Apoptosis (ML-IAP)

2002 • 161 citations

Development and Characterization of Nonpeptidic Small Molecule Inhibitors of the XIAP/Caspase-3 Interaction

2003 • 121 citations

Role of XIAP in the malignant phenotype of transitional cell cancer (TCC) and therapeutic activity of XIAP antisense oligonucleotides against multidrug‐resistant TCC in vitro

2002 • 117 citations

Expression of inhibitors of apoptosis (IAP) proteins in non-small cell human lung cancer

2002 • 108 citations

Assessment of IAP (inhibitor of apoptosis) proteins as predictors of response to chemotherapy in advanced non-small-cell lung cancer patients

2001 • 103 citations

Advances in the use of synthetic combinatorial chemistry: Mixture-based libraries

2003 • 100 citations

The hippocampal neurons of neuronal apoptosis inhibitory protein 1 (NAIP1)-deleted mice display increased vulnerability to kainic acid-induced injury

2000 • 98 citations

Functional blocks in caspase activation pathways are common in leukemia and predict patient response to induction chemotherapy.

2003 • 84 citations

Inhibitor of apoptosis protein-1 promotes tumor cell survival in mesothelioma

2002 • 73 citations

An efficient two-step synthesis of mono-, di- and triureas from resin-bound amides

2000 • 15 citations