Aberrant NF-κB signaling in lymphoma: mechanisms, consequences, and therapeutic implications

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

2000 • 9,712 citations

NF-κB regulation in the immune system

2002 • 3,804 citations

The Use of Molecular Profiling to Predict Survival after Chemotherapy for Diffuse Large-B-Cell Lymphoma

2002 • 3,769 citations

Signaling to NF-κB

2004 • 3,768 citations

Kaposi's Sarcoma–Associated Herpesvirus-Like DNA Sequences in AIDS-Related Body-Cavity–Based Lymphomas

1995 • 2,833 citations

NF-κB at the crossroads of life and death

2002 • 2,684 citations

The two NF-κB activation pathways and their role in innate and adaptive immunity

2004 • 2,476 citations

Bortezomib or High-Dose Dexamethasone for Relapsed Multiple Myeloma

2005 • 2,457 citations

Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori

1993 • 2,132 citations

NF-κB is a target of AKT in anti-apoptotic PDGF signalling

1999 • 1,830 citations

FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

2006 • 1,135 citations

Molecular Diagnosis of Primary Mediastinal B Cell Lymphoma Identifies a Clinically Favorable Subgroup of Diffuse Large B Cell Lymphoma Related to Hodgkin Lymphoma

2003 • 1,080 citations

Constitutive Nuclear Factor κB Activity Is Required for Survival of Activated B Cell–like Diffuse Large B Cell Lymphoma Cells

2001 • 1,035 citations

A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma

2003 • 1,010 citations

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells.

1997 • 780 citations

NF-κB Function in Growth Control: Regulation of Cyclin D1 Expression and G₀/G₁-to-S-Phase Transition

1999 • 777 citations

Isolation of a new type C retrovirus (HTLV) in primary uncultured cells of a patient with Sézary T-cell leukaemia

1981 • 758 citations

Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells.

1996 • 749 citations

The Apoptosis Inhibitor Gene API2 and a Novel 18q Gene,MLT, Are Recurrently Rearranged in the t(11;18)(q21;q21) Associated With Mucosa-Associated Lymphoid Tissue Lymphomas

1999 • 714 citations

Bcl10 Is Involved in t(1;14)(p22;q32) of MALT B Cell Lymphoma and Mutated in Multiple Tumor Types

1999 • 666 citations

A loss-of-function RNA interference screen for molecular targets in cancer

2006 • 597 citations

Survival of Resting Mature B Lymphocytes Depends on BCR Signaling via the Igα/β Heterodimer

2004 • 552 citations

Bcl10 Is a Positive Regulator of Antigen Receptor–Induced Activation of NF-κ B and Neural Tube Closure

2001 • 551 citations

Foxp3 interacts with nuclear factor of activated T cells and NF-κB to repress cytokine gene expression and effector functions of T helper cells

2005 • 525 citations

Bcl10 activates the NF-κB pathway through ubiquitination of NEMO

2003 • 524 citations

FOXP2 and the neuroanatomy of speech and language

2005 • 486 citations

HTLV-I Tax Induces Cellular Proteins that Activate the κB Element in the IL-2 Receptor α Gene

1988 • 480 citations

Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro.

1990 • 439 citations

Molecular mechanisms of novel therapeutic approaches for multiple myeloma

2002 • 431 citations

The Inhibitor of Death Receptor Signaling, Flice-Inhibitory Protein Defines a New Class of Tumor Progression Factors

1999 • 425 citations

Regulation of the human interleukin-2 receptor α chain promoter: Activation of a nonfunctional promoter by the transactivator gene of HTLV-I

1987 • 423 citations

Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus, type I.

1987 • 413 citations

Bcl10 and MALT1, Independent Targets of Chromosomal Translocation in MALT Lymphoma, Cooperate in a Novel NF-κB Signaling Pathway

2001 • 409 citations

Characterization of the Intracellular Domain of Receptor Activator of NF-κB (RANK)

1998 • 408 citations

B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-κB p50

1991 • 403 citations

Regulation of lymphocyte proliferation and death by flip

2001 • 385 citations

Differential Requirement for Malt1 in T and B Cell Antigen Receptor Signaling

2003 • 375 citations

Epstein-Barr virus and Hodgkin's disease: transcriptional analysis of virus latency in the malignant cells.

1993 • 368 citations

Regulation of NF-κB-Dependent Lymphocyte Activation and Development by Paracaspase

2003 • 366 citations

T(3;14)(p14.1;q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma

2005 • 364 citations

Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I.

1995 • 364 citations

A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue

1999 • 354 citations

Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IκBα

1999 • 347 citations

Chromosomal and Gene Amplification in Diffuse Large B-Cell Lymphoma

1998 • 340 citations

High-level nuclear NF-kappa B and Oct-2 is a common feature of cultured Hodgkin/Reed-Sternberg cells

1996 • 328 citations

KSHV vFLIP Is Essential for the Survival of Infected Lymphoma Cells

2004 • 326 citations

Canonical NF-κB Activity, Dispensable for B Cell Development, Replaces BAFF-Receptor Signals and Promotes B Cell Proliferation upon Activation

2006 • 315 citations

Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling.

2005 • 314 citations

Inhibition of NF-κB induces apoptosis of KSHV-infected primary effusion lymphoma cells

2000 • 307 citations

Signals from within: the DNA-damage-induced NF-κB response

2006 • 295 citations

Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha

2001 • 294 citations

Modulation of the NF-κB pathway by virally encoded Death Effector Domains-containing proteins

1999 • 294 citations

Clonal Deleterious Mutations in the Iκbα Gene in the Malignant Cells in Hodgkin's Lymphoma

2000 • 287 citations

Molecular mechanisms of constitutive NF-κB/Rel activation in Hodgkin/Reed-Sternberg cells

1999 • 285 citations

Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I

2006 • 277 citations

Bay 11-7082 inhibits transcription factor NF-kappa B and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells

2002 • 276 citations

HTLV-I Tax Protein Binds to MEKK1 to Stimulate IκB Kinase Activity and NF-κB Activation

1998 • 260 citations

The Human Herpes Virus 8-encoded Viral FLICE Inhibitory Protein Physically Associates with and Persistently Activates the IκB Kinase Complex

2002 • 246 citations

Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2

2002 • 241 citations

The gastric marginal zone B-cell lymphoma of MALT type

2000 • 233 citations

Hodgkin's lymphoma

2003 • 233 citations

Recurrent involvement of the REL and BCL11Aloci in classical Hodgkin lymphoma

2002 • 233 citations

TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-κB pathway by TRAF-binding TNFRs

2005 • 232 citations

Small Molecule Inhibitors of IκB Kinase Are Selectively Toxic for Subgroups of Diffuse Large B-Cell Lymphoma Defined by Gene Expression Profiling

2005 • 219 citations

Identification of the gene responsible for human T-cell leukaemia virus transcriptional regulation

1985 • 215 citations

TRAF2 Differentially Regulates the Canonical and Noncanonical Pathways of NF-κB Activation in Mature B Cells

2004 • 211 citations

Ligand-independent signaling by overexpressed CD30 drives NF-κB activation in Hodgkin–Reed-Sternberg cells

2002 • 207 citations

Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel

1999 • 204 citations

Molecular Diagnosis of the Hematologic Cancers

2003 • 200 citations

Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro

1990 • 181 citations

Persistent activation of NF-κB by the Tax transforming protein of HTLV-1: hijacking cellular IκB kinases

1999 • 181 citations

Epstein-Barr Virus Latent Gene Expression in Primary Effusion Lymphomas Containing Kaposi's Sarcoma–Associated Herpesvirus/Human Herpesvirus-8

1997 • 180 citations

Gastric Hyperplasia and Increased Proliferative Responses of Lymphocytes in Mice Lacking the COOH-terminal Ankyrin Domain of NF-κB2

1997 • 178 citations

Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma

2003 • 172 citations

Proteasome inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple myeloma

2003 • 169 citations

Transactivation of the c-myc promoter by human T cell leukemia virus type 1 tax is mediated by NF kappa B.

1992 • 159 citations

Inhibition of NF-κB essentially contributes to arsenic-induced apoptosis

2003 • 156 citations

Biology of Hodgkin's lymphoma

2002 • 152 citations

Inactivating I kappa B epsilon mutations in Hodgkin/Reed–Sternberg cells

2003 • 151 citations

The multifaceted roles of TRAFs in the regulation of B-cell function

2004 • 151 citations

Constitutive NF-κB activation by the t(11;18)(q21;q21) product in MALT lymphoma is linked to deregulated ubiquitin ligase activity

2005 • 135 citations

Functional expression of receptor activator of nuclear factor κB in Hodgkin disease cell lines

2001 • 133 citations

The role of NF-κB-1 and NF-κB-2-mediated resistance to apoptosis in lymphomas

2006 • 111 citations

Human T-cell leukemia virus type I Tax associates with and is negatively regulated by the NF-kappa B2 p100 gene product: implications for viral latency.

1994 • 109 citations

Epstein–Barr virus-encoded latent infection membrane protein 1 regulates the processing of p100 NF-κB2 to p52 via an IKKγ/NEMO-independent signalling pathway

2003 • 107 citations

The tax gene of human T-cell leukemia virus type 2 is essential for transformation of human T lymphocytes

1996 • 88 citations

A Human T-cell Leukemia Virus Tax Variant Incapable of Activating NF-κB Retains Its Immortalizing Potential for Primary T-lymphocytes

1998 • 86 citations

The Inhibitor of Apoptosis Protein Fusion c-IAP2·MALT1 Stimulates NF-κB Activation Independently of TRAF1 AND TRAF2

2006 • 85 citations

Epstein-Barr Virus Latent Gene Expression in Primary Effusion Lymphomas Containing Kaposi's Sarcoma–Associated Herpesvirus/Human Herpesvirus-8

1997 • 82 citations

Similar patterns of genomic alterations characterize primary mediastinal large‐B‐cell lymphoma and diffuse large‐B‐cell lymphoma

2001 • 73 citations

Persistent Activation of NF-κB by the Tax Transforming Protein Involves Chronic Phosphorylation of IκB Kinase Subunits IKKβ and IKKγ

2001 • 66 citations

Cytoplasmic Aggregation of TRAF2 and TRAF5 Proteins in the Hodgkin-Reed-Sternberg Cells

2002 • 64 citations

Members of the Nuclear Factor κB Family Transactivate the Murine c-myb Gene

1995 • 55 citations

From antigen to activation: specific signal transduction pathways linking antigen receptors to NF-κB

2003 • 52 citations

SIGNALS FROM WITHIN: THE DNADAMAGE- INDUCED NF-KAPPAB RESPONSE

2006 • 51 citations

The Apoptosis Inhibitor Gene API2 and a Novel 18q Gene,MLT, Are Recurrently Rearranged in the t(11;18)(q21;q21) Associated With Mucosa-Associated Lymphoid Tissue Lymphomas

1999 • 48 citations

Proteasome Inhibition as a New Therapeutic Principle in Hematological Malignancies

2006 • 45 citations

History of the treatment of psoriasis

1992 • 42 citations

Lack of IKBA coding region mutations in primary mediastinal large B-cell lymphoma and the host response subtype of diffuse large B-cell lymphoma

2006 • 15 citations

Mutational analysis of the IκBα gene in activated B cell‐like diffuse large B‐cell lymphoma

2004 • 14 citations

Use of bortezomib in B-cell non-Hodgkin’s lymphoma

2006 • 11 citations

Deleted Work

1955 • 0 citations