Mechanisms of Neuropathic Pain

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

1988 • 5,129 citations

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

1992 • 3,001 citations

Spared nerve injury: an animal model of persistent peripheral neuropathic pain

2000 • 2,067 citations

A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury

1990 • 1,819 citations

SENSORY DISTURBANCES FROM CEREBRAL LESIONS

1911 • 1,786 citations

Central sensitization and LTP: do pain and memory share similar mechanisms?

2003 • 1,406 citations

Reflex sympathetic dystrophy: changing concepts and taxonomy

1995 • 1,093 citations

Role of the Immune system in chronic pain

2005 • 1,075 citations

Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain

2003 • 1,064 citations

Expression of C‐fos‐like protein as a marker for neuronal activity following noxious stimulation in the rat

1990 • 1,009 citations

Wall and Melzack's Textbook of Pain

2005 • 997 citations

Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms

1991 • 942 citations

Peripheral and central mechanisms of cutaneous hyperalgesia

1992 • 896 citations

Partial Peripheral Nerve Injury Promotes a Selective Loss of GABAergic Inhibition in the Superficial Dorsal Horn of the Spinal Cord

2002 • 828 citations

Central changes in processing of mechanoreceptive input in capsaicin‐induced secondary hyperalgesia in humans.

1992 • 785 citations

Neuropathic pain and spinal microglia: a big problem from molecules in ‘small’ glia

2004 • 778 citations

Painful neuropathy: altered central processing maintained dynamically by peripheral input

1992 • 770 citations

Neuronal Plasticity and Signal Transduction in Nociceptive Neurons: Implications for the Initiation and Maintenance of Pathological Pain

2001 • 727 citations

Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons

1991 • 616 citations

The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy

2005 • 613 citations

Adrenergic Excitation of Cutaneous Pain Receptors Induced by Peripheral Nerve Injury

1991 • 599 citations

Efficacy of pregabalin in neuropathic pain evaluated in a 12-week, randomised, double-blind, multicentre, placebo-controlled trial of flexible- and fixed-dose regimens

2005 • 576 citations

Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2

2003 • 575 citations

Myelinated afferents signal the hyperalgesia associated with nerve injury

1988 • 565 citations

Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy

2004 • 547 citations

Long-term potentiation and long-term depression of primary afferent neurotransmission in the rat spinal cord

1993 • 521 citations

Potent Analgesic Effects of GDNF in Neuropathic Pain States

2000 • 506 citations

Tumour necrosis factor-α induces ectopic activity in nociceptive primary afferent fibres

1997 • 506 citations

Activation of CB ₂ cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS

2003 • 469 citations

Nociceptor modulated central sensitization causes mechanical hyperalgesia in acute chemogenic and chronic neuropathic pain

1994 • 469 citations

The Effect of Site and Type of Nerve Injury on Spinal Glial Activation and Neuropathic Pain Behavior

1999 • 435 citations

Tactile allodynia in the absence of C-fiber activation: altered firing properties of DRG neurons following spinal nerve injury

2000 • 433 citations

Endoneurial injection of TNF-α produces neuropathic pain behaviors

1996 • 421 citations

Early Onset of Spontaneous Activity in Uninjured C-Fiber Nociceptors after Injury to Neighboring Nerve Fibers

2001 • 409 citations

Spontaneous Pain, Both Neuropathic and Inflammatory, Is Related to Frequency of Spontaneous Firing in Intact C-Fiber Nociceptors

2006 • 406 citations

Blocking Caspase Activity Prevents Transsynaptic Neuronal Apoptosis and the Loss of Inhibition in Lamina II of the Dorsal Horn after Peripheral Nerve Injury

2005 • 403 citations

A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons

2006 • 386 citations

VR1 protein expression increases in undamaged DRG neurons after partial nerve injury

2001 • 383 citations

Electrophysiological Properties of Mutant Na_v1.7 Sodium Channels in a Painful Inherited Neuropathy

2004 • 376 citations

Ionotropic and Metabotropic Receptors, Protein Kinase A, Protein Kinase C, and Src Contribute to C-Fiber-Induced ERK Activation and cAMP Response Element-Binding Protein Phosphorylation in Dorsal Horn Neurons, Leading to Central Sensitization

2004 • 376 citations

Sodium Channels and Mechanisms of Neuropathic Pain

2006 • 372 citations

Denervated Schwann Cells Attract Macrophages by Secretion of Leukemia Inhibitory Factor (LIF) and Monocyte Chemoattractant Protein-1 in a Process Regulated by Interleukin-6 and LIF

2002 • 366 citations

Aβ-fiber nociceptive primary afferent neurons: a review of incidence and properties in relation to other afferent A-fiber neurons in mammals

2004 • 362 citations

Immune regulation of central nervous system functions: from sickness responses to pathological pain

2005 • 356 citations

Central post-stroke pain — a study of the mechanisms through analyses of the sensory abnormalities

1989 • 351 citations

Time-Dependent Descending Facilitation from the Rostral Ventromedial Medulla Maintains, But Does Not Initiate, Neuropathic Pain

2002 • 343 citations

Involvement of the Proinflammatory Cytokines Tumor Necrosis Factor-α, IL-1β, and IL-6 But Not IL-8 in the Development of Heat Hyperalgesia: Effects on Heat-Evoked Calcitonin Gene-Related Peptide Release from Rat Skin

2000 • 342 citations

Biochemical pharmacology of the vanilloid receptor TRPV1

2004 • 329 citations

The function of microglia through purinergic receptors: Neuropathic pain and cytokine release

2005 • 325 citations

Transient Receptor Potential Vanilloid 4 Is Essential in Chemotherapy-Induced Neuropathic Pain in the Rat

2004 • 318 citations

A comparison of the potential role of the tetrodotoxin-insensitive sodium channels, PN3/SNS and NaN/SNS2, in rat models of chronic pain

1999 • 317 citations

Brain-Derived Neurotrophic Factor Increases in the Uninjured Dorsal Root Ganglion Neurons in Selective Spinal Nerve Ligation Model

2001 • 315 citations

Upregulation of a Silent Sodium Channel After Peripheral, but not Central, Nerve Injury in DRG Neurons

1999 • 298 citations

Peripheral mechanisms of cutaneous nociception

2006 • 294 citations

Roles of capsaicin-insensitive nociceptors in cutaneous pain and secondary hyperalgesia

2001 • 294 citations

Systemic Alpha-adrenergic Blockade with Phentolamine

1991 • 294 citations

T lymphocytes play a role in neuropathic pain following peripheral nerve injury in rats

2004 • 286 citations

Uninjured C-Fiber Nociceptors Develop Spontaneous Activity and α-Adrenergic Sensitivity Following L₆ Spinal Nerve Ligation in Monkey

1999 • 280 citations

Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation.

2003 • 274 citations

Mechanical hyperalgesia after an L5 spinal nerve lesion in the rat is not dependent on input from injured nerve fibers

2000 • 269 citations

Secondary hyperalgesia and perceptual wind-up following intradermal injection of capsaicin in humans

1998 • 262 citations

Degeneration of Myelinated Efferent Fibers Induces Spontaneous Activity in Uninjured C-Fiber Afferents

2002 • 260 citations

Inhibition of Neuropathic Pain by Selective Ablation of Brainstem Medullary Cells Expressing the μ-Opioid Receptor

2001 • 259 citations

Increased Sensitivity of Injured and Adjacent Uninjured Rat Primary Sensory Neurons to Exogenous Tumor Necrosis Factor-α after Spinal Nerve Ligation

2003 • 256 citations

Prolonged relief of neuralgia after regional anesthetic blocks. A call for further experimental and systematic clinical studies

1990 • 250 citations

Spinal Dorsal Horn Calcium Channel α₂δ-1 Subunit Upregulation Contributes to Peripheral Nerve Injury-Induced Tactile Allodynia

2004 • 246 citations

Synaptic strengthening through activation of Ca2+ -permeable AMPA receptors

1996 • 236 citations

Myelinated Mechanically Insensitive Afferents From Monkey Hairy Skin: Heat-Response Properties

1998 • 234 citations

Intradermal injection of norepinephrine evokes pain in patients with sympathetically maintained pain

2000 • 228 citations

The role of tumor necrosis factor-alpha in the neuropathic pain induced by Lumbar 5 ventral root transection in rat

2006 • 227 citations

Pro- and Anti-inflammatory Cytokine Gene Expression in Rat Sciatic Nerve Chronic Constriction Injury Model of Neuropathic Pain

2001 • 221 citations

Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats

2006 • 212 citations

Reversal of experimental neuropathic pain by T-type calcium channel blockers

2003 • 211 citations

Anti-hyperalgesic and morphine-sparing actions of propentofylline following peripheral nerve injury in rats: mechanistic implications of spinal glia and proinflammatory cytokines

2003 • 205 citations

Functional imaging of allodynia in complex regional pain syndrome

2006 • 205 citations

Axotomized and Intact Muscle Afferents But No Skin Afferents Develop Ongoing Discharges of Dorsal Root Ganglion Origin after Peripheral Nerve Lesion

2000 • 204 citations

Possible chemical contribution from chromic gut sutures produces disorders of pain sensation like those seen in man

1993 • 197 citations

An fMRI study of cerebral processing of brush-evoked allodynia in neuropathic pain patients

2006 • 193 citations

Brain processing of capsaicin-induced secondary hyperalgesia

1999 • 191 citations

Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy

2001 • 191 citations

Patterns of quantitative sensation testing of hypoesthesia and hyperalgesia are predictive of diabetic polyneuropathy: a study of three cohorts. Nerve growth factor study group.

2000 • 185 citations

A Conditional Deletion of the NR1 Subunit of the NMDA Receptor in Adult Spinal Cord Dorsal Horn Reduces NMDA Currents and Injury-Induced Pain

2003 • 181 citations

Peripheral axonal injury results in reduced μ opioid receptor pre- and post-synaptic action in the spinal cord☆

2005 • 176 citations

Differential regulation of P2X3 mRNA expression by peripheral nerve injury in intact and injured neurons in the rat sensory ganglia

2001 • 175 citations

Discharge pattern of afferent fibers from a neuroma

1984 • 170 citations

Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin

2005 • 170 citations

An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine

2005 • 169 citations

Change in mRNAs for neuropeptides and the GABAA receptor in dorsal root ganglion neurons in a rat experimental neuropathic pain model

1998 • 168 citations

Genetic impairment of interleukin-1 signaling attenuates neuropathic pain, autotomy, and spontaneous ectopic neuronal activity, following nerve injury in mice

2006 • 163 citations

Leukaemia inhibitory factor is required for normal inflammatory responses to injury in the peripheral and central nervous systems in vivo and is chemotactic for macrophages in vitro

2000 • 161 citations

Multiple actions of systemic artemin in experimental neuropathy

2003 • 159 citations

GFRalpha3 is expressed predominantly in nociceptive sensory neurons

2001 • 156 citations

Calcium channel alpha2-delta type 1 subunit is the major binding protein for pregabalin in neocortex, hippocampus, amygdala, and spinal cord: An ex vivo autoradiographic study in alpha2-delta type 1 genetically modified mice

2006 • 154 citations

Distinct neurochemical features of acute and persistent pain

1999 • 147 citations

Key role of the dorsal root ganglion in neuropathic tactile hypersensibility

2003 • 141 citations

Response of nerves to injury in relation to neuropathic pain

2006 • 140 citations

Combined application of excitatory amino acids and substance P produces long-lasting changes in responses of primate spinothalamic tract neurons

1993 • 134 citations

Nerve injury-induced tactile allodynia is mediated via ascending spinal dorsal column projections

2001 • 128 citations

Sodium Channel β2 Subunits Regulate Tetrodotoxin-Sensitive Sodium Channels in Small Dorsal Root Ganglion Neurons and Modulate the Response to Pain

2006 • 128 citations

Erythermalgia: molecular basis for an inherited pain syndrome

2005 • 128 citations

Mechanical hyperalgesia in streptozotocin-diabetic rats

1993 • 123 citations

Central Origin of Secondary Mechanical Hyperalgesia

2003 • 122 citations

Upregulation of the Voltage-Gated Sodium Channel β2 Subunit in Neuropathic Pain Models: Characterization of Expression in Injured and Non-Injured Primary Sensory Neurons

2005 • 118 citations

Low dose of tetrodotoxin reduces neuropathic pain behaviors in an animal model

2000 • 116 citations

Neurotrophic factors and neuropathic pain

2001 • 116 citations

Axotomy induces preprotachykinin gene expression in a subpopulation of dorsal root ganglion neurons

1994 • 115 citations

Mechanical and heat sensitization of cutaneous nociceptors in rats with experimental peripheral neuropathy

2005 • 112 citations

UPREGULATION OF SPINAL GLUTAMATE RECEPTORS IN CHRONIC PAIN

1996 • 112 citations

Sympathetic sprouting and changes in nociceptive sensory innervation in the glabrous skin of the rat hind paw following partial peripheral nerve injury

2006 • 111 citations

Tactile allodynia, but not thermal hyperalgesia, of the hindlimbs is blocked by spinal transection in rats with nerve injury

1998 • 109 citations

Abnormal substance P release from the spinal cord following injury to primary sensory neurons

2000 • 108 citations

Behavioral manifestations of an experimental model for peripheral neuropathy produced by spinal nerve ligation in the primate

1994 • 108 citations

Pharmacological evaluation of the selective spinal nerve ligation model of neuropathic pain in the rat

2004 • 104 citations

Selective Mediation of Nerve Injury-Induced Tactile Hypersensitivity by Neuropeptide Y

2002 • 104 citations

A Randomized, Double-Masked, Placebo-Controlled Pilot Trial of Extended IV Lidocaine Infusion for Relief of Ongoing Neuropathic Pain

2006 • 103 citations

Neural activation during experimental allodynia: a functional magnetic resonance imaging study

2004 • 103 citations

The surgical treatment of painful traumatic neuromas

1993 • 101 citations

Function of Posterior Columns in Man

1965 • 99 citations

Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGLUR5) antagonist, in experimental neuropathic pain in rats

2000 • 99 citations

Mechanical hyperalgesia after an L5 ventral rhizotomy or an L5 ganglionectomy in the rat

2002 • 98 citations

Functional imaging of the human trigeminal system: Opportunities for new insights into pain processing in health and disease

2004 • 96 citations

The extent of cytokine induction in peripheral nerve lesions depends on the mode of injury and NMDA receptor signaling

2004 • 91 citations

Nerve lesions and the generation of pain

2001 • 88 citations

Antinociceptive effects of tetrodotoxin (TTX) in rodents

2006 • 87 citations

Prolonged primary afferent induced alterations in dorsal horn neurones, an intracellular analysis in vivo and in vitro.

1988 • 84 citations

Primary Afferent Fibers That Contribute to Increased Substance P Receptor Internalization in the Spinal Cord After Injury

1999 • 84 citations

Dorsal root section elicits signs of neuropathic pain rather than reversing them in rats with L5 spinal nerve injury

2000 • 78 citations

Upregulation of mRNAs coding for AMPA and NMDA receptor subunits and metabotropic glutamate receptors in the dorsal horn of the spinal cord in a rat model of diabetes mellitus

2005 • 73 citations

Interleukin-10 reduces the endotoxin-induced hyperalgesia in mice

1998 • 69 citations

Effects of combined hemotoxic and anterolateral spinal lesions on nociceptive sensitivity

1999 • 60 citations

Microvascular Decompression

2002 • 51 citations

Peripheral effects of morphine in neuropathic rats: role of sympathetic postganglionic nerve fibers

2001 • 46 citations

Emerging strategies for the treatment of neuropathic pain

2006 • 43 citations

Chapter 12 Release of neuropeptides in the spinal cord

1995 • 42 citations

Mechanical sensitivity of regenerating myelinated skin and muscle afferents in the cat

1995 • 40 citations

Alteration in sensitivity of ionotropic glutamate receptors and tachykinin receptors in spinal cord contribute to development and maintenance of nerve injury-evoked neuropathic pain

2006 • 36 citations

Emerging Strategies for the Treatment of Neuropathic Pain

2006 • 34 citations

Sensory basis of autotomy in rats

1991 • 34 citations

Silas Weir Mitchell, MD: the physician who discovered causalgia

2004 • 21 citations

Spinal nerve injury increases the percentage of cold-responsive DRG neurons

2004 • 17 citations

Deleted Work

1955 • 0 citations