Blocking Caspase Activity Prevents Transsynaptic Neuronal Apoptosis and the Loss of Inhibition in Lamina II of the Dorsal Horn after Peripheral Nerve Injury

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

1988 • 5,129 citations

Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+

1995 • 5,025 citations

Pathobiology of ischaemic stroke: an integrated view

1999 • 3,776 citations

Neuronal Plasticity: Increasing the Gain in Pain

2000 • 3,672 citations

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

1992 • 3,001 citations

Spared nerve injury: an animal model of persistent peripheral neuropathic pain

2000 • 2,067 citations

Apoptosis in the nervous system

2000 • 1,850 citations

Organelle-specific initiation of cell death pathways

2001 • 1,454 citations

Functional repression of cAMP response element in 6-hydroxydopamine-treated neuronal cells.

2006 • 1,287 citations

Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration

2000 • 1,215 citations

A decade of caspases

2003 • 1,084 citations

Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain

2003 • 1,064 citations

Inhibition of Human Caspases by Peptide-based and Macromolecular Inhibitors

1998 • 984 citations

Apoptosis and Caspases in Neurodegenerative Diseases

2003 • 852 citations

Stereological methods for estimating the total number of neurons and synapses: issues of precision and bias

1999 • 842 citations

Partial Peripheral Nerve Injury Promotes a Selective Loss of GABAergic Inhibition in the Superficial Dorsal Horn of the Spinal Cord

2002 • 828 citations

Can we conquer pain?

2002 • 803 citations

Neuropathic pain and spinal microglia: a big problem from molecules in ‘small’ glia

2004 • 778 citations

Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model

2000 • 700 citations

The Yin and Yang of NMDA receptor signalling

2003 • 627 citations

Bad news from the brain: descending 5-HT pathways that control spinal pain processing

2004 • 464 citations

The somatotopic organization of primary afferent terminals in the superficial laminae of the dorsal horn of the rat spinal cord

1985 • 446 citations

Early Onset of Spontaneous Activity in Uninjured C-Fiber Nociceptors after Injury to Neighboring Nerve Fibers

2001 • 409 citations

Apoptosis in Parkinson's disease: Signals for neuronal degradation

2003 • 386 citations

Caspase inhibitors

1999 • 372 citations

Transsynaptic degeneration in the superficial dorsal horn after sciatic nerve injury: effects of a chronic constriction injury, transection, and strychnine

1990 • 356 citations

GABA and its receptors in the spinal cord

1996 • 304 citations

To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways

2003 • 296 citations

Loss of GABA-immunoreactivity in the spinal dorsal horn of rats with peripheral nerve injury and promotion of recovery by adrenal medullary grafts

1996 • 285 citations

Spinal GABAAand GABABReceptor Pharmacology in a Rat Model of Neuropathic Pain

2002 • 277 citations

Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn

2003 • 263 citations

Adult neuron survival strategies — slamming on the brakes

2004 • 238 citations

Selective loss of spinal GABAergic or glycinergic neurons is not necessary for development of thermal hyperalgesia in the chronic constriction injury model of neuropathic pain

2003 • 223 citations

Delayed loss of small dorsal root ganglion cells after transection of the rat sciatic nerve

2000 • 217 citations

Spontaneous activity of axotomized afferent neurons after L5 spinal nerve injury in rats

2000 • 204 citations

Axotomized and Intact Muscle Afferents But No Skin Afferents Develop Ongoing Discharges of Dorsal Root Ganglion Origin after Peripheral Nerve Lesion

2000 • 204 citations

Primary afferent‐evoked glycine‐ and GABA‐mediated IPSPs in substantia gelatinosa neurones in the rat spinal cord in vitro.

1995 • 183 citations

Changes in GAD- and GABA- immunoreactivity in the spinal dorsal horn after peripheral nerve injury and promotion of recovery by lumbar transplant of immortalized serotonergic precursors

1998 • 181 citations

Lack of evidence for significant neuronal loss in laminae I–III of the spinal dorsal horn of the rat in the chronic constriction injury model

2004 • 150 citations

Peripheral nerve injury alters excitatory synaptic transmission in lamina II of the rat dorsal horn

2003 • 147 citations

Distribution and colocalisation of glutamate decarboxylase isoforms in the rat spinal cord

2003 • 137 citations

Cell death in the superficial dorsal horn in a model of neuropathic pain

2001 • 135 citations

Axotomy-Induced Apoptotic Cell Death of Neonatal Rat Facial Motoneurons: Time Course Analysis and Relation to NADPH-Diaphorase Activity

1996 • 108 citations

Functional reorganization of sensory pathways in the rat spinal dorsal horn following peripheral nerve injury

2001 • 81 citations

Peripheral nerve insult induces NMDA receptor-mediated, delayed degeneration in spinal neurons

1998 • 80 citations

Blockade of glutamate mGlu5 receptors in a rat model of neuropathic pain prevents early over-expression of pro-apoptotic genes and morphological changes in dorsal horn lamina II

2004 • 78 citations

Synaptic transmission and plasticity in the superficial dorsal horn

2000 • 69 citations

Setting the tone: superficial dorsal horn projection neurons regulate pain sensitivity

2004 • 59 citations

A‐fiber sensory input induces neuronal cell death in the dorsal horn of the adult rat spinal cord

2001 • 57 citations

Development of Neuropathic Pain in the Rat Spared Nerve Injury Model Is Not Prevented by a Peripheral Nerve Block

2003 • 51 citations