Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

1988 • 5,129 citations

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

1992 • 3,001 citations

TRP channels as cellular sensors

2003 • 2,625 citations

Textbook of pain

1999 • 2,566 citations

Identification of a cold receptor reveals a general role for TRP channels in thermosensation

2002 • 2,513 citations

ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures

2003 • 2,386 citations

A TRP Channel that Senses Cold Stimuli and Menthol

2002 • 2,182 citations

Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

2004 • 1,823 citations

A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury

1990 • 1,819 citations

Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin

2004 • 1,746 citations

p38 MAPK Activation by NGF in Primary Sensory Neurons after Inflammation Increases TRPV1 Levels and Maintains Heat Hyperalgesia

2002 • 1,196 citations

Can we conquer pain?

2002 • 803 citations

Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain

1994 • 803 citations

GLIA: A novel drug discovery target for clinical pain

2003 • 661 citations

Nociceptor and Hair Cell Transducer Properties of TRPA1, a Channel for Pain and Hearing

2005 • 626 citations

TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury

2005 • 605 citations

Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: Evidence for a regulatory function of nerve growth factor in vivo

1992 • 603 citations

The Pungency of Garlic: Activation of TRPA1 and TRPV1 in Response to Allicin

2005 • 583 citations

Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with Aδ/C-fibers and colocalization with Trk receptors

2007 • 571 citations

Nerve growth factor and nociception

1993 • 530 citations

Differential Expression of the mRNA for the Vanilloid Receptor Subtype 1 in Cells of the Adult Rat Dorsal Root and Nodose Ganglia and Its Downregulation by Axotomy

1999 • 506 citations

Thermosensation and pain

2004 • 486 citations

The cytokine network of Wallerian degeneration: tumor necrosis factor-alpha, interleukin-1alpha, and interleukin-1beta.

2002 • 476 citations

Nociceptor modulated central sensitization causes mechanical hyperalgesia in acute chemogenic and chronic neuropathic pain

1994 • 469 citations

The Cytokine Network of Wallerian Degeneration: Tumor Necrosis Factor-α, Interleukin-1α, and Interleukin-1β

2002 • 432 citations

Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8

2002 • 414 citations

Early Onset of Spontaneous Activity in Uninjured C-Fiber Nociceptors after Injury to Neighboring Nerve Fibers

2001 • 409 citations

Comparison of three rodent neuropathic pain models

1997 • 407 citations

VR1 protein expression increases in undamaged DRG neurons after partial nerve injury

2001 • 383 citations

Redistribution of Na_V1.8 in Uninjured Axons Enables Neuropathic Pain

2003 • 359 citations

Lessons from peppers and peppermint: the molecular logic of thermosensation

2003 • 337 citations

TRP ion channels in the nervous system

2004 • 316 citations

Brain-Derived Neurotrophic Factor Increases in the Uninjured Dorsal Root Ganglion Neurons in Selective Spinal Nerve Ligation Model

2001 • 315 citations

Role of Mitogen-Activated Protein Kinase Activation in Injured and Intact Primary Afferent Neurons for Mechanical and Heat Hypersensitivity after Spinal Nerve Ligation

2004 • 309 citations

Possible role of inflammatory mediators in tactile hypersensitivity in rat models of mononeuropathy

2000 • 306 citations

Substance P induced by peripheral nerve injury in primary afferent sensory neurons and its effect on dorsal column nucleus neurons

1995 • 298 citations

Uninjured C-Fiber Nociceptors Develop Spontaneous Activity and α-Adrenergic Sensitivity Following L₆ Spinal Nerve Ligation in Monkey

1999 • 280 citations

Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation.

2003 • 274 citations

How Cold is It? TRPM8 and TRPA1 in the Molecular Logic of Cold Sensation

2005 • 273 citations

Mechanical hyperalgesia after an L5 spinal nerve lesion in the rat is not dependent on input from injured nerve fibers

2000 • 269 citations

Responsiveness and functional attributes of electrically localized terminals of cutaneous C-fibers in vivo and in vitro

1992 • 259 citations

Increased Sensitivity of Injured and Adjacent Uninjured Rat Primary Sensory Neurons to Exogenous Tumor Necrosis Factor-α after Spinal Nerve Ligation

2003 • 256 citations

Functional Downregulation of P2X₃Receptor Subunit in Rat Sensory Neurons Reveals a Significant Role in Chronic Neuropathic and Inflammatory Pain

2002 • 254 citations

Contribution of injured and uninjured dorsal root ganglion neurons to pain behavior and the changes in gene expression following chronic constriction injury of the sciatic nerve in rats

2002 • 244 citations

TRPA1 and TRPM8 activation in humans: effects of cinnamaldehyde and menthol

2005 • 242 citations

Painful mononeuropathy in C57BL/Wld mice with delayed Wallerian degeneration: differential effects of cytokine production and nerve regeneration on thermal and mechanical hypersensitivity

1998 • 234 citations

Peripheral cell types contributing to the hyperalgesic action of nerve growth factor in inflammation

1996 • 232 citations

Differential Activation of Extracellular Signal-Regulated Protein Kinase in Primary Afferent Neurons Regulates Brain-Derived Neurotrophic Factor Expression after Peripheral Inflammation and Nerve Injury

2003 • 231 citations

Neuropathic pain and injured nerve: Peripheral mechanisms

1991 • 228 citations

Similar Electrophysiological Changes in Axotomized and Neighboring Intact Dorsal Root Ganglion Neurons

2003 • 221 citations

Peripheral administration of nerve growth factor in the adult rat produces a thermal hyperalgesia that requires the presence of sympathetic post-ganglionic neurones

1995 • 220 citations

Nerve Growth Factor Regulates the Expression of Brain-Derived Neurotrophic Factor mRNA in the Peripheral Nervous System

1996 • 209 citations

Axotomized and Intact Muscle Afferents But No Skin Afferents Develop Ongoing Discharges of Dorsal Root Ganglion Origin after Peripheral Nerve Lesion

2000 • 204 citations

The cold plate as a test of nociceptive behaviors: description and application to the study of chronic neuropathic and inflammatory pain models

1998 • 194 citations

Nerve growth factor regulates VR-1 mRNA levels in cultures of adult dorsal root ganglion neurons

2001 • 188 citations

VR1, but not P2X3, increases in the spared L4 DRG in rats with L5 spinal nerve ligation

2002 • 185 citations

Sympathetic sprouting in the dorsal root ganglia of the injured peripheral nerve in a rat neuropathic pain model

1996 • 183 citations

ThermoTRP channels and cold sensing: what are they really up to?

2005 • 180 citations

Central suppression of cold-induced C fibre pain by myelinated fibre input

1989 • 177 citations

Differential regulation of P2X3 mRNA expression by peripheral nerve injury in intact and injured neurons in the rat sensory ganglia

2001 • 175 citations

Change in mRNAs for neuropeptides and the GABAA receptor in dorsal root ganglion neurons in a rat experimental neuropathic pain model

1998 • 168 citations

Wallerian degeneration is required for both neuropathic pain and sympathetic sprouting into the DRG

1997 • 167 citations

TRPM8 mRNA Is Expressed in a Subset of Cold-Responsive Trigeminal Neurons From Rat

2003 • 166 citations

Response properties of high-threshold cutaneous cold receptors in the primate

1982 • 160 citations

Differential activation of MAPK in injured and uninjured DRG neurons following chronic constriction injury of the sciatic nerve in rats

2004 • 145 citations

Axonal transport of VR1 capsaicin receptor mRNA in primary afferents and its participation in inflammation‐induced increase in capsaicin sensitivity

2001 • 139 citations

Cold-evoked pain varies with skin type and cooling rate: a psychophysical study in humans

1999 • 133 citations

Spinal nerve ligation: what to blame for the pain and why

2000 • 130 citations

Nerve growth factor induced hyperalgesia in the rat hind paw is dependent on circulating neutrophils

1998 • 127 citations

Reduced Hyperalgesia in Nerve-Injured WLD Mice: Relationship to Nerve Fiber Phagocytosis, Axonal Degeneration, and Regeneration in Normal Mice

1996 • 124 citations

Differential expression patterns of mRNAs for P2X receptor subunits in neurochemically characterized dorsal root ganglion neurons in the rat

2004 • 124 citations

Response of C fibre nociceptors in the anaesthetized monkey to heat stimuli: correlation with pain threshold in humans.

1995 • 119 citations

Cold transduction in rat trigeminal ganglia neurons in vitro

2003 • 117 citations

Comparison of sympathetic sprouting in sensory ganglia in three animal models of neuropathic pain

1998 • 106 citations

Increase of preprotachykinin mRNA and substance P immunoreactivity in spared dorsal root ganglion neurons following partial sciatic nerve injury

1998 • 105 citations

Contribution of degeneration of motor and sensory fibers to pain behavior and the changes in neurotrophic factors in rat dorsal root ganglion

2004 • 80 citations

Dorsal root section elicits signs of neuropathic pain rather than reversing them in rats with L5 spinal nerve injury

2000 • 78 citations

The effect of site and type of nerve injury on the expression of brain-derived neurotrophic factor in the dorsal root ganglion and on neuropathic pain behavior

2005 • 76 citations

Protease M/neurosin mRNA is expressed in mature oligodendrocytes

1999 • 74 citations

Capsaicin-sensitive afferents mediate chronic cold, but not mechanical, allodynia-like behavior in spinally injured rats

1996 • 65 citations

TRPV2, a capsaicin receptor homologue, is expressed predominantly in the neurotrophin-3-dependent subpopulation of primary sensory neurons

2004 • 61 citations

Increase of Calcitonin Gene-Related Peptide Immunoreactivity in the Axonal Fibers of the Gracile Nuclei of Adult and Aged Rats after Complete and Partial Sciatic Nerve Injuries

1998 • 55 citations

Expression of HGF and cMet in the peripheral nervous system of adult rats following sciatic nerve injury

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Contribution of the Spared Primary Afferent Neurons to the Pathomechanisms of Neuropathic Pain

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Response of cat skin mechanothermal nociceptors to cold stimulation

1985 • 29 citations

Spinal nerve injury increases the percentage of cold-responsive DRG neurons

2004 • 17 citations

Capsaicin-sensitive primary afferents mediate responses to cold in rats with a peripheral mononeuropathy

2002 • 16 citations

Up-regulation of preprotachykinin and calcitonin gene-related peptide messenger RNA in L4 dorsal root ganglion neurons following L5 spinal nerve ligation; a rat neuropathic pain model

1998 • 6 citations