Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin

Ethical guidelines for investigations of experimental pain in conscious animals

1983 • 7,639 citations

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

1992 • 3,001 citations

Gabapentin for the Symptomatic Treatment of Painful Neuropathy in Patients With Diabetes Mellitus<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

1998 • 1,544 citations

Gabapentin for the Treatment of Postherpetic Neuralgia<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

1998 • 1,461 citations

The Novel Anticonvulsant Drug, Gabapentin (Neurontin), Binds to the α2δ Subunit of a Calcium Channel

1996 • 1,164 citations

Efficacy of pharmacological treatments of neuropathic pain: an update and effect related to mechanism of drug action

1999 • 1,148 citations

Chronic pain and medullary descending facilitation

2002 • 968 citations

Wind-up of spinal cord neurones and pain sensation: much ado about something?

2000 • 679 citations

Inhibition of Hyperalgesia by Ablation of Lamina I Spinal Neurons Expressing the Substance P Receptor

1997 • 622 citations

Upregulation of Dorsal Root Ganglion α₂δ Calcium Channel Subunit and Its Correlation with Allodynia in Spinal Nerve-Injured Rats

2001 • 601 citations

The molecular dynamics of pain control

2001 • 589 citations

Synaptic Plasticity in Spinal Lamina I Projection Neurons That Mediate Hyperalgesia

2003 • 550 citations

Pain Pathways and Parabrachial Circuits in the Rat

2002 • 547 citations

Supraspinal contributions to hyperalgesia

1999 • 512 citations

Bad news from the brain: descending 5-HT pathways that control spinal pain processing

2004 • 464 citations

Transmission of Chronic Nociception by Spinal Neurons Expressing the Substance P Receptor

1999 • 446 citations

Gabapentin in neuropathic pain syndromes: a randomised, double-blind, placebo-controlled trial

2002 • 427 citations

Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways

2002 • 423 citations

Descending modulation in persistent pain: an update

2002 • 420 citations

Comparison of three rodent neuropathic pain models

1997 • 407 citations

Injury Type-Specific Calcium Channel α₂δ-1 Subunit Up-Regulation in Rat Neuropathic Pain Models Correlates with Antiallodynic Effects of Gabapentin

2002 • 377 citations

The 5-HT₃Subtype of Serotonin Receptor Contributes to Nociceptive Processing via a Novel Subset of Myelinated and Unmyelinated Nociceptors

2002 • 365 citations

Glutamatergic activation of anterior cingulate cortex produces an aversive teaching signal

2004 • 342 citations

Pregabalin and gabapentin reduce release of substance P and CGRP from rat spinal tissues only after inflammation or activation of protein kinase C

2003 • 333 citations

Gabapentin (neurontin) and S‐(+)‐3‐isobutylgaba represent a novel class of selective antihyperalgesic agents

1997 • 329 citations

The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain

1997 • 317 citations

Gabapentin and pregabalin, but not morphine and amitriptyline, block both static and dynamic components of mechanical allodynia induced by streptozocin in the rat

1999 • 292 citations

What should we be measuring in behavioral studies of chronic pain in animals?

2004 • 285 citations

Neurokinin 1 receptor expression by neurons in laminae I, III and IV of the rat spinal dorsal horn that project to the brainstem

2000 • 276 citations

Descending facilitatory modulation of a behavioral nociceptive response by stimulation in the adult rat anterior cingulate cortex

2000 • 258 citations

Chronic neuropathic pain is accompanied by global changes in gene expression and shares pathobiology with neurodegenerative diseases

2002 • 256 citations

The Anti-Allodynic Effects of Amitriptyline, Gabapentin, and Lidocaine in a Rat Model of Neuropathic Pain

1998 • 252 citations

Spinal Neurons that Possess the Substance P Receptor Are Required for the Development of Central Sensitization

2002 • 232 citations

The effects of GABAB agonists and gabapentin on mechanical hyperalgesia in models of neuropathic and inflammatory pain in the rat

2001 • 210 citations

Descending facilitatory control of mechanically evoked responses is enhanced in deep dorsal horn neurones following peripheral nerve injury

2004 • 209 citations

Effects of spinally delivered N- and P-type voltage-dependent calcium channel antagonists on dorsal horn neuronal responses in a rat model of neuropathy

2001 • 191 citations

Glial cell line-derived neurotrophic factor normalizes neurochemical changes in injured dorsal root ganglion neurons and prevents the expression of experimental neuropathic pain

2003 • 165 citations

Localization of N-type Ca 2+ channels in the rat spinal cord following chronic constrictive nerve injury

2002 • 141 citations

Role of descending noradrenergic system and spinal α₂‐adrenergic receptors in the effects of gabapentin on thermal and mechanical nociception after partial nerve injury in the mouse

2005 • 139 citations

Does a Single Intravenous Injection of the 5HT3 Receptor Antagonist Ondansetron Have an Analgesic Effect in Neuropathic Pain? A Double-Blinded, Placebo-Controlled Cross-Over Study

2003 • 138 citations

An excitatory role for 5-HT in spinal inflammatory nociceptive transmission; state-dependent actions via dorsal horn 5-HT3 receptors in the anaesthetized rat

2000 • 134 citations

Effects of systemic carbamazepine and gabapentin on spinal neuronal responses in spinal nerve ligated rats

1998 • 127 citations

Differential subcellular localization of the 5‐HT₃‐A_s receptor subunit in the rat central nervous system

2002 • 123 citations

The 5-HT3 receptor facilitates at-level mechanical allodynia following spinal cord injury

2004 • 122 citations

Gabapentin is not a GABAB receptor agonist

2001 • 122 citations

Gabapentin, ineffective in normal rats, markedly reduces C-fibre evoked responses after inflammation

1997 • 121 citations

The Anticonvulsant Gabapentin (Neurontin) Does Not Act through γ-Aminobutyric Acid-B Receptors

2002 • 108 citations

Localization of 5-HT3 receptors in the rat spinal cord

1995 • 101 citations

Enlargement of the Receptive Field Size to Low Intensity Mechanical Stimulation in the Rat Spinal Nerve Ligation Model of Neuropathy

2000 • 83 citations

Neuropathic pain

2000 • 68 citations

Differential effects of intrathecally administered N- and P-type voltage-sensitive calcium channel blockers upon two models of experimental mononeuropathy in the rat

1998 • 67 citations

Synergistic Effect between Intrathecal Non-NMDA Antagonist and Gabapentin on Allodynia Induced by Spinal Nerve Ligation in Rats

2000 • 66 citations

Changes in Expression of Voltage-Dependent Ion Channel Subunits in Dorsal Root Ganglia of Rats with Radicular Injury and Pain

2002 • 63 citations

Spinal neurons involved in the generation of at-level pain following spinal injury in the rat

2004 • 44 citations

Effect of K+ channel modulators on the antiallodynic effect of gabapentin

2003 • 43 citations

Spinal Neurons That Express NK-1 Receptors Modulate Descending Controls That Project Through the Dorsolateral Funiculus

2004 • 39 citations

Characterisation of axon terminals in the rat dorsal horn that are immunoreactive for serotonin 5-HT3A receptor subunits

2003 • 38 citations