Possible chemical contribution from chromic gut sutures produces disorders of pain sensation like those seen in man

Statistical principles in experimental design.

1962 • 27,228 citations

Statistical Principles in Experimental Design

1964 • 8,376 citations

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

1988 • 5,129 citations

Localization of nitric oxide synthase indicating a neural role for nitric oxide

1990 • 2,996 citations

THE PHARMACOLOGICAL BASIS OF THERAPEUTICS

1967 • 1,039 citations

The Pharmacological Basis of Therapeutics.

1971 • 774 citations

Endogenous nitric oxide: physiology, pathology and clinical relevance

1991 • 766 citations

Further evidence for ‘pain-related’ behaviours in a model of unilateral peripheral mononeuropathy

1990 • 504 citations

Causalgia and Other Reflex Sympathetic Dystrophies

1973 • 481 citations

Spontaneous discharge originates in the dorsal root ganglion at the onset of a painful peripheral neuropathy in the rat

1992 • 419 citations

Transsynaptic degeneration in the superficial dorsal horn after sciatic nerve injury: effects of a chronic constriction injury, transection, and strychnine

1990 • 356 citations

The spectrum of fiber loss in a model of neuropathic pain in the rat: an electron microscopic study

1991 • 247 citations

Pharmacological evidence that endothelium-derived relaxing factor is nitric oxide: use of pyrogallol and superoxide dismutase to study endothelium-dependent and nitric oxide-elicited vascular smooth muscle relaxation.

1988 • 229 citations

Early and late effects of prolonged topical capsaicin on cutaneous sensibility and neurogenic vasodilatation in humans

1991 • 167 citations

Up-regulation of opioid gene expression in spinal cord evoked by experimental nerve injuries and inflammation

1991 • 161 citations

Association of Painful and Painless Diabetic Polyneuropathy With Different Patterns of Nerve Fiber Degeneration and Regeneration

1990 • 153 citations

Endothelium-derived relaxing factor

1989 • 149 citations

An experimental painful peripheral neuropathy due to nerve constriction

1992 • 129 citations

Is large myelinated fiber loss associated with hyperalgesia in a model of experimental peripheral neuropathy in the rat?

1993 • 127 citations

Peripheral Nerve Abnormalities in Aging Rats

1981 • 122 citations

Low pH-induced release of calcitonin gene-related peptide from capsaicin-sensitive sensory nerves: Mechanism of action and biological response

1991 • 111 citations

CO₂ laser‐induced pain‐related somatosensory evoked potentials in peripheral neuropathies: Correlation between electrophysiological and histopathological findings

1991 • 111 citations

Bilateral and differential changes in spinal mu, delta and kappa opioid binding in rats with a painful, unilateral neuropathy

1991 • 108 citations

Weighted needle pinprick sensory thresholds: a simple test of sensory function in diabetic peripheral neuropathy.

1992 • 108 citations

Treatment of Painful Diabetic Neuropathy with Topical Capsaicin

1989 • 108 citations

Alterations in myelinated fibres in the sciatic nerve of rats after constriction: possible relationships between the presence of abnormal small myelinated fibres and pain-related behaviour

1990 • 100 citations

Treatment of painful diabetic neuropathy with topical capsaicin. A multicenter, double-blind, vehicle-controlled study. The Capsaicin Study Group

1991 • 99 citations

Pain Syndromes in Neurology

1991 • 90 citations

Hyperthermic injury versus crush injury in the rat sciatic nerve: A comparative functional, histopathological and morphometrical study

1992 • 56 citations

The role of the sympathetic nervous system in painful peripheral neuropathy

1991 • 49 citations

Treatment of reflex sympathetic dystrophy with topical capsaicin. Case report

1990 • 49 citations

Association of painful and painless diabetic polyneuropathy with different patterns of nerve fiber degeneration and regeneration

1990 • 45 citations

Neurochemical evidence for the activation of the ‘efferent’ function of capsaicin-sensitive nerves by lowering of the pH in the guinea-pig urinary bladder

1990 • 43 citations

Is there a role for an endothelium-derived relaxing factor in nociception?

1990 • 42 citations

Hyperalgesia and Allodynia

1993 • 34 citations

Suture Material in Bladder Surgery a Comparison of Polydioxanone, Polyglactin, and Chromic Catgut

1990 • 31 citations

Reflex sympathetic dystrophy syndrome: diagnosis and treatment

1990 • 11 citations

A quick and accurate line-sampling technique to quantify myelinated axons in peripheral nerve cross-sections

1991 • 7 citations