Neuronal Plasticity and Signal Transduction in Nociceptive Neurons: Implications for the Initiation and Maintenance of Pathological Pain

Neuronal Plasticity: Increasing the Gain in Pain

2000 • 3,672 citations

The MAPK signaling cascade

1995 • 3,300 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human

1999 • 2,692 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

Neuropathic pain: aetiology, symptoms, mechanisms, and management

1999 • 2,228 citations

Evidence for a central component of post-injury pain hypersensitivity

1983 • 2,103 citations

The induction and maintenance of central sensitization is dependent on N -methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states

1991 • 1,963 citations

Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase

1996 • 1,253 citations

CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression

1996 • 1,109 citations

The MAPK cascade is required for mammalian associative learning

1998 • 1,086 citations

Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB

1990 • 1,061 citations

Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulation

1992 • 962 citations

Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila

1994 • 959 citations

Nerve growth factor regulates expression of neuropeptide genes in adult sensory neurons

1989 • 934 citations

Activity-dependent neuronal plasticity following tissue injury and inflammation

1992 • 933 citations

Cross Talk between ERK and PKA Is Required for Ca2+ Stimulation of CREB-Dependent Transcription and ERK Nuclear Translocation

1998 • 885 citations

A Requirement for the Mitogen-activated Protein Kinase Cascade in Hippocampal Long Term Potentiation

1997 • 866 citations

Calcium Influx via the NMDA Receptor Induces Immediate Early Gene Transcription by a MAP Kinase/ERK-Dependent Mechanism

1996 • 781 citations

Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity

1999 • 752 citations

Messenger plasticity in primary sensory neurons following axotomy and its functional implications

1994 • 743 citations

Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB

1994 • 732 citations

NEURONAL Ca²⁺/CALMODULIN-DEPENDENT PROTEIN KINASES

1992 • 713 citations

Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras

1994 • 704 citations

Identification of a Signaling Pathway Involved in Calcium Regulation of BDNF Expression

1998 • 687 citations

Preserved Acute Pain and Reduced Neuropathic Pain in Mice Lacking PKCγ

1997 • 685 citations

NMDA Channel Regulation by Channel-Associated Protein Tyrosine Kinase Src

1997 • 614 citations

Making New Connections

1999 • 601 citations

Induction of CRE-Mediated Gene Expression by Stimuli That Generate Long-Lasting LTP in Area CA1 of the Hippocampus

1996 • 594 citations

Transcriptional and posttranslational plasticity and the generation of inflammatory pain

1999 • 560 citations

The Mitogen-Activated Protein Kinase Cascade Couples PKA and PKC to cAMP Response Element Binding Protein Phosphorylation in Area CA1 of Hippocampus

1999 • 542 citations

Neuronal Activity-Dependent Cell Survival Mediated by Transcription Factor MEF2

1999 • 510 citations

Differential Expression of the mRNA for the Vanilloid Receptor Subtype 1 in Cells of the Adult Rat Dorsal Root and Nodose Ganglia and Its Downregulation by Axotomy

1999 • 506 citations

Nerve Growth Factor Treatment Increases Brain-Derived Neurotrophic Factor Selectively in TrkA-Expressing Dorsal Root Ganglion Cells and in Their Central Terminations within the Spinal Cord

1997 • 500 citations

Nerve Growth Factor Activates Extracellular Signal-Regulated Kinase and p38 Mitogen-Activated Protein Kinase Pathways To Stimulate CREB Serine 133 Phosphorylation

1998 • 495 citations

Peptides and the primary afferent nociceptor

1993 • 486 citations

p38 Mitogen-activated Protein Kinase Phosphorylates Cytosolic Phospholipase A2 (cPLA2) in Thrombin-stimulated Platelets

1996 • 466 citations

Stimulation of Protein Tyrosine Phosphorylation by NMDA Receptor Activation

1991 • 464 citations

A Novel Nociceptor Signaling Pathway Revealed in Protein Kinase C ε Mutant Mice

1999 • 439 citations

Neurotrophins: Peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity

1999 • 434 citations

Specific Involvement of PKC-ε in Sensitization of the Neuronal Response to Painful Heat

1999 • 414 citations

Cyclooxygenase-2: Molecular Biology, Pharmacology, and Neurobiology

1999 • 412 citations

Light and circadian rhythmicity regulate MAP kinase activation in the suprachiasmatic nuclei

1998 • 364 citations

Extracellular Signal-Regulated Kinase (ERK) Controls Immediate Early Gene Induction on Corticostriatal Stimulation

1998 • 335 citations

Up‐regulation of cyclooxygenase‐2 mRNA in the rat spinal cord following peripheral inflammation

1996 • 331 citations

Glutamate Induces Phosphorylation of Elk-1 and CREB, Along with c -fos Activation, via an Extracellular Signal-Regulated Kinase-Dependent Pathway in Brain Slices

1999 • 310 citations

Serine 133-Phosphorylated CREB Induces Transcription via a Cooperative Mechanism That May Confer Specificity to Neurotrophin Signals

1995 • 292 citations

Role of Protein Kinase A in the Maintenance of Inflammatory Pain

1999 • 258 citations

The spinal biology in humans and animals of pain states generated by persistent small afferent input

1999 • 253 citations

Leukemia inhibitory factor mediates an injury response but not a target-directed developmental transmitter switch in sympathetic neurons

1993 • 244 citations

Mediation of primary afferent peripheral hyperalgesia by the cAMP second messenger system

1989 • 242 citations

Peripheral Axotomy Induces Long-Term c-Jun Amino-Terminal Kinase-1 Activation and Activator Protein-1 Binding Activity by c-Jun and junD in Adult Rat Dorsal Root GangliaIn Vivo

1998 • 236 citations

Diminished Inflammation and Nociceptive Pain with Preservation of Neuropathic Pain in Mice with a Targeted Mutation of the Type I Regulatory Subunit of cAMP-Dependent Protein Kinase

1997 • 227 citations

Phosphorylation of Transcription Factor CREB in Rat Spinal Cord after Formalin-Induced Hyperalgesia: Relationship toc-fosInduction

1997 • 213 citations

Nitric oxide synthase‐like immunoreactivity in lumbar dorsal root ganglia and spinal cord of rat and monkey and effect of peripheral axotomy

1993 • 210 citations

Axotomy Upregulates the Anterograde Transport and Expression of Brain-Derived Neurotrophic Factor by Sensory Neurons

1998 • 193 citations

AMPA receptor–PDZ interactions in facilitation of spinal sensory synapses

1999 • 190 citations

NK-1 and NK-3 type tachykinin receptor mRNA expression in the rat spinal cord dorsal horn is increased during adjuvant or formalin- induced nociception

1994 • 187 citations

Contribution of protein kinase C to central sensitization and persistent pain following tissue injury

1992 • 182 citations

Heat Shock Protein 27: Developmental Regulation and Expression after Peripheral Nerve Injury

1998 • 176 citations

A Role for HSP27 in Sensory Neuron Survival

1999 • 162 citations

Intracellular Messengers Contributing to Persistent Nociception and Hyperalgesia Induced by _L‐Glutamate and Substance P in the Rat Formalin Pain Model

1994 • 155 citations

Expression of neuropeptide Y and neuropeptide Y (Y1) receptor mRNA in rat spinal cord and dorsal root ganglia following peripheral tissue inflammation

1994 • 152 citations

Pain-related increases in spinal cord membrane-bound protein kinase C following peripheral nerve injury

1992 • 150 citations

Cyclic GMP pathway is critical for inducing long–term sensitization of nociceptive sensory neurons

1999 • 138 citations

The effects of G-protein and protein kinase inhibitors on the behavioral responses of rats to intradermal injection of capsaicin

1997 • 127 citations

Noxious thermal and chemical stimulation induce increases in 3H-phorbol 12,13-dibutyrate binding in spinal cord dorsal horn as well as persistent pain and hyperalgesia, which is reduced by inhibition of protein kinase C

1995 • 125 citations

Organization, structure, and expression of the gene encoding the rat substance P receptor

1991 • 123 citations

Endogenous mechanisms of sensory modulation

1999 • 122 citations

Central and peripheral expression of galanin in response to inflammation

1995 • 117 citations

Involvement of Mitogen-Activated Protein Kinase Homologues in the Regulation of Lipopolysaccharide-Mediated Induction of Cyclo-oxygenase-2 but not Nitric Oxide Synthase in RAW 264.7 Macrophages

1999 • 103 citations

CP-96,345, but not its stereoisomer, CP-96,344, blocks the nociceptive responses to intrathecally administered substance P and to noxious thermal and chemical stimuli in the rat

1993 • 94 citations

Transcription factor regulation of prodynorphin gene expression following rat hindpaw inflammation

1998 • 92 citations

Molecular mechanisms of pain: Serotonin1A receptor agonists trigger transactivation by c-fos of the prodynorphin gene in spinal cord neurons

1993 • 86 citations

Increased expression of neuronal nitric oxide synthase in dorsal root ganglion neurons after systemic capsaicin administration

1995 • 78 citations

Identification of p42 Mitogen‐Activated Protein Kinase as a Tyrosine Kinase Substrate Activated by Maximal Electroconvulsive Shock in Hippocampus

1993 • 72 citations

Prominent Expression of bFGF in Dorsal Root Ganglia after Axotomy

1995 • 66 citations

Building blocks of pain: the regulation of key molecules in spinal sensory neurones during development and following peripheral axotomy

1999 • 62 citations

Null Mutations Lacking Substance: Elucidating Pain Mechanisms by Genetic Pharmacology

1998 • 57 citations

Alpha subunit of calcium/calmodulin-dependent protein kinase enhances excitatory amino acid and synaptic responses of rat spinal dorsal horn neurons

1994 • 55 citations

aFGF, bFGF and NGF differentially regulate neuropeptide expression in dorsal root ganglia after axotomy and induce autotomy

1996 • 44 citations

An isobolographic analysis of the effects of N‐methyl‐D‐aspartate and NK₁ tachykinin receptor antagonists on inflammatory hyperalgesia in the rat

1996 • 42 citations

Immunohistochemical detection of calcium/calmodulin‐dependent protein kinase II in the spinal cord of the rat and monkey with special reference to the corticospinal tract

1994 • 41 citations

Evidence for a role of protein kinase C in the sustained activation of rat dorsal horn neurons evoked by cutaneous mustard oil application

1994 • 35 citations

Regulation of the second-messenger systems in the rat spinal cord during prolonged peripheral inflammation

1994 • 32 citations

Morphine, the NMDA receptor antagonist MK801 and the tachykinin NK1 receptor antagonist RP67580 attenuate the development of inflammation-induced progressive tactile hypersensitivity

1998 • 31 citations

Second messengers, the substantia gelatinosa and injury-induced persistent pain

1999 • 29 citations

Spatial Considerations for Stimulus-Dependent Transcription in Neurons

2000 • 28 citations

Ca2+/calmodulin-dependent protein kinase type IV in dorsal root ganglion: colocalization with peptides, axonal transport and effect of axotomy

1996 • 16 citations

The role of adrenocortical mitochondrial malic enzyme in NADPH generation

1972 • 13 citations