A Conditional Deletion of the NR1 Subunit of the NMDA Receptor in Adult Spinal Cord Dorsal Horn Reduces NMDA Currents and Injury-Induced Pain

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A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

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Cloned Glutamate Receptors

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The induction and maintenance of central sensitization is dependent on N -methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states

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Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulation

1992 • 962 citations

Activity-dependent neuronal plasticity following tissue injury and inflammation

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A Complete Protocol forIn SituHybridization of Messenger RNAs in Brain and Other Tissues With Radio-labeled Single-Stranded RNA Probes

1989 • 883 citations

Light and electron microscope distribution of the NMDA receptor subunit NMDAR1 in the rat nervous system using a selective anti-peptide antibody

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Partial Peripheral Nerve Injury Promotes a Selective Loss of GABAergic Inhibition in the Superficial Dorsal Horn of the Spinal Cord

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Central changes in processing of mechanoreceptive input in capsaicin‐induced secondary hyperalgesia in humans.

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Regulation of NMDA receptors by tyrosine kinases and phosphatases

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The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury

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A Proposed Test Battery and Constellations of Specific Behavioral Paradigms to Investigate the Behavioral Phenotypes of Transgenic and Knockout Mice

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Central nervous system plasticity in the tonic pain response to subcutaneous formalin injection

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Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing

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Formalin-evoked activity in identified primary afferent fibers: systemic lidocaine suppresses phase-2 activity

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A Complete Protocol for <I>In Situ</I> Hybridization of Messenger RNAs in Brain and Other Tissues With Radio-labeled Single-Stranded RNA Probes

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Comparison of the Antinociceptive Effects of Pre- and Posttreatment with Intrathecal Morphine and MK801, an NMDA Antagonist, on the Formalin Test in the Rat

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Dynamic alterations in the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat spinal cord

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Primary afferent-evoked synaptic responses and slow potential generation in rat substantia gelatinosa neurons in vitro

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Blind patch-clamp recordings from substantia gelatinosa neurons in adult rat spinal cord slices: Pharmacological properties of synaptic currents

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Spinal systems and pain processing: development of novel analgesic drugs with mechanistically defined models

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The synthetic cannabinoid WIN55,212‐2 attenuates hyperalgesia and allodynia in a rat model of neuropathic pain

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NMDA receptor antagonists as analgesics: focus on the NR2B subtype

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Targeted Retrograde Gene Delivery for Neuronal Protection

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Sensitization of cat dorsal horn neurons to innocuous mechanical stimulation after intradermal injection of capsaicin

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Distinct spatiotemporal distributions of the N‐Methyl‐<scp>D</scp>‐aspartate receptor channel subunit mRNAs in the mouse cervical cord

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Dextromethorphan attenuates and reverses analgesic tolerance to morphine

1994 • 121 citations

Competitive and non-competitive NMDA antagonists block the development of antinociceptive tolerance to morphine, but not to selective μ or δ opioid agonists in mice

1996 • 111 citations

Expression of the mRNA for the rat NMDA receptor (NMDAR1) in the sensory and autonomic ganglion neurons

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The cutaneous contribution to the hamstring flexor reflex in the rat: an electrophysiological and anatomical study

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d-Methadone is antinociceptive in the rat formalin test.

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The N-methyl-d-aspartate (NMDA) receptor is postsynaptic to substance P-containing axon terminals in the rat superficial dorsal horn

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Dextromethorphan suppresses both formalin-induced nociceptive behavior and the formalin-induced increase in spinal cord c- fos mRNA

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Evidence for Tonic Activation of NK-1 Receptors during the Second Phase of the Formalin Test in the Rat

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Glutamate-induced currents reveal three functionally distinct NMDA receptor populations in rat dorsal horn – effects of peripheral nerve lesion and inflammation

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Ultrastructural evidence for presynaptic μ opioid receptor modulation of synaptic plasticity in NMDA-receptor-containing dendrites in the dentate gyrus

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Decreased expression of N-methyl-d-aspartate (NMDA) receptors in rat dorsal root ganglion following complete Freund's adjuvant-induced inflammation: an immunocytochemical study for NMDA NR1 subunit

1999 • 29 citations

Antinociceptive effects after intrathecal administration of phosphodiester-, 2′-O-allyl-, and C-5-propyne-modified antisense oligodeoxynucleotides targeting the NMDAR1 subunit in mouse

2001 • 23 citations

Antisense oligonucleotides to N-methyl-d-aspartate receptor subunits attenuate formalin-induced nociception in the rat

2002 • 20 citations

Co-localization of Mu opioid receptor and N-methyl-D-aspartate receptor in the trigeminal dorsal horn

2002 • 5 citations