Interleukin-10 reduces the endotoxin-induced hyperalgesia in mice

Ethical guidelines for investigations of experimental pain in conscious animals

1983 • 7,639 citations

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

1991 • 3,812 citations

IL-10 inhibits cytokine production by activated macrophages.

1991 • 2,919 citations

Interleukin-10

1993 • 1,820 citations

Trophic factors and neuronal survival

1989 • 1,631 citations

Macrophage deactivation by interleukin 10.

1991 • 1,253 citations

Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve

1987 • 1,000 citations

Interleukin 10 protects mice from lethal endotoxemia.

1993 • 807 citations

The pivotal role of tumour necrosis factor α in the development of inflammatory hyperalgesia

1992 • 786 citations

The neurotrophic factor concept: a reexamination

1993 • 745 citations

IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages.

1992 • 709 citations

Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity

1994 • 685 citations

COX-1 and COX-2 tissue expression: implications and predictions.

1997 • 670 citations

Cytokines, nerve growth factor and inflammatory hyperalgesia: the contribution of tumour necrosis factor α

1997 • 667 citations

Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-gamma or IL-10.

1993 • 657 citations

Immune activation: the role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states

1995 • 656 citations

Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: Evidence for a regulatory function of nerve growth factor in vivo

1992 • 603 citations

Contribution of interleukin‐1β to the inflammation‐induced increase in nerve growth factor levels and inflammatory hyperalgesia

1995 • 573 citations

Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-beta and interleukin-10

1992 • 516 citations

Characterization of cytokine-induced hyperalgesia

1994 • 506 citations

An Enzyme‐Linked Immunoassay for Nerve Growth Factor (NGF): A Tool for Studying Regulatory Mechanisms Involved in NGF Production in Brain and in Peripheral Tissues

1987 • 377 citations

Regulation of Nerve Growth Factor (NGF) Synthesis in the Rat Central Nervous System: Comparison between the Effects of Interleukin‐1 and Various Growth Factors in Astrocyte Cultures and in vivo

1990 • 369 citations

Biological properties of interleukin 10

1992 • 359 citations

Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation.

1992 • 352 citations

Interleukin-10

1992 • 303 citations

Bradykinin initiates cytokine‐mediated inflammatory hyperalgesia

1993 • 279 citations

Interleukin-1 β and tumor necrosis factor-α synergistically stimulate nerve growth factor (NGF) release from cultured rat astrocytes

1990 • 233 citations

The role of NGF in sensory neurons in vivo

1986 • 233 citations

Cytokine‐mediated inflammatory hyperalgesia limited by interleukin‐4

1999 • 221 citations

Cell-type-specific regulation of nerve growth factor (NGF) synthesis in non-neuronal cells: comparison of Schwann cells with other cell types

1991 • 211 citations

Synergy between tumor necrosis factor α and interleukin-1 in the induction of sickness behavior in mice

1994 • 199 citations

Effect of endotoxin in IL-1 beta-deficient mice.

1996 • 190 citations

Interleukin 10 suppression of monocyte prostaglandin H synthase-2. Mechanism of inhibition of prostaglandin-dependent matrix metalloproteinase production.

1994 • 187 citations

Tumor necrosis factor stimulates the synthesis and secretion of biologically active nerve growth factor in non-neuronal cells.

1993 • 168 citations

Cytokine‐mediated inflammatory hyperalgesia limited by interleukin‐10

1995 • 156 citations

Regulation by Interleukin‐1 of Nerve Growth Factor Secretion and Nerve Growth Factor mRNA Expression in Rat Primary Astroglial Cultures

1991 • 153 citations

Effects of IL-10 on systemic inflammatory responses during sublethal primate endotoxemia.

1997 • 145 citations

Endotoxin-induced local inflammation and hyperalgesia in rats and mice: a new model for inflammatory pain

1996 • 142 citations

Inhibition by interleukin-10 of inducible cyclooxygenase expression in lipopolysaccharide-stimulated monocytes: its underlying mechanism in comparison with interleukin-4

1995 • 105 citations

Assay of Pyrogens by Interleukin-6 Release from Monocytic Cell Lines

1991 • 99 citations

Regulation of β‐nerve growth factor expression by inflammatory mediators in hippocampal cultures

1990 • 99 citations

Regulation by anti‐inflammatory cytokines (IL‐4, IL‐10, IL‐13, TGFβ)of interleukin‐8 production by LPS‐ and/ or TNFα‐activated human polymorphonuclear cells

1996 • 86 citations

IL‐4 and IL‐13 exhibit comparable abilities to reduce pyrogen‐induced expression of procoagulant activity in endothelial cells and monocytes

1993 • 78 citations

Interleukin-1 (IL-1) receptor antagonist prevents Staphylococcus epidermidis-induced hypotension and reduces circulating levels of tumor necrosis factor and IL-1 beta in rabbits

1993 • 74 citations

Immune complexes inhibit antimicrobial responses through interleukin-10 production. Effects in severe combined immunodeficient mice during Listeria infection.

1995 • 70 citations

IL-10 and IL-4 synergize with TNF-α to induce IL-1ra production by human neutrophils

1996 • 70 citations

Involvement of interleukin‐1β, nerve growth factor and prostaglandin E₂ in endotoxin‐induced localized inflammatory hyperalgesia

1997 • 55 citations

Effect of morphine on lipopolysaccharide-induced tumor necrosis factor-α production in vivo: involvement of the sympathetic nervous system

1997 • 52 citations

Zinc Reduces the Hyperalgesia and Upregulation of NGF and IL-1β Produced by Peripheral Inflammation in the Rat

1996 • 33 citations

Effects of Various Analgesic and Anti-Inflammatory Drugs on Endotoxin-lnduced Hyperalgesia in Rats and Mice

1997 • 26 citations