Sympathetic sprouting and changes in nociceptive sensory innervation in the glabrous skin of the rat hind paw following partial peripheral nerve injury

Ethical guidelines for investigations of experimental pain in conscious animals

1983 • 7,639 citations

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

1988 • 5,129 citations

The Nerve Growth Factor 35 Years Later

1987 • 3,107 citations

Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain

1994 • 803 citations

Peripheral nerve injury triggers noradrenergic sprouting within dorsal root ganglia

1993 • 730 citations

Ongoing activity in peripheral nerves: the physiology and pharmacology of impulses originating from a neuroma

1975 • 610 citations

Adrenergic Excitation of Cutaneous Pain Receptors Induced by Peripheral Nerve Injury

1991 • 599 citations

A hypothesis on the physiological basis for causalgia and related pains

1986 • 566 citations

Causalgia and Other Reflex Sympathetic Dystrophies

1973 • 481 citations

Topical application of clonidine relieves hyperalgesia in patients with sympathetically maintained pain

1991 • 385 citations

Systemic Alpha-adrenergic Blockade with Phentolamine

1991 • 294 citations

Development of ongoing activity, mechanosensitivity, and adrenaline sensitivity in severed peripheral nerve axons

1981 • 289 citations

Uninjured C-Fiber Nociceptors Develop Spontaneous Activity and α-Adrenergic Sensitivity Following L₆ Spinal Nerve Ligation in Monkey

1999 • 280 citations

Pathophysiology of damaged nerves in relation to chronic pain

1999 • 269 citations

Activation of myelinated afferents ending in a neuroma by stimulation of the sympathetic supply in the rat

1981 • 254 citations

Interleukin‐6 Production by Schwann Cells and Induction in Sciatic Nerve Injury

1995 • 254 citations

Noradrenaline-evoked pain in neuralgia

1995 • 241 citations

Intradermal injection of norepinephrine evokes pain in patients with sympathetically maintained pain

2000 • 228 citations

Fixed-diameter polyethylene cuffs applied to the rat sciatic nerve induce a painful neuropathy: ultrastructural morphometric analysis of axonal alterations

1996 • 222 citations

Effects of sympathectomy on a rat model of peripheral neuropathy

1993 • 212 citations

Effects of sympathectomy in a model of causalgiform pain produced by partial sciatic nerve injury in rats

1991 • 186 citations

Sympathetic sprouting in the dorsal root ganglia of the injured peripheral nerve in a rat neuropathic pain model

1996 • 183 citations

Spinal nerve lesion-induced mechanoallodynia and adrenergic sprouting in sensory ganglia are attenuated in interleukin-6 knockout mice

1998 • 172 citations

Abnormalities of sympathetic innervation in the area of an injured peripheral nerve in a rat model of neuropathic pain

1993 • 162 citations

Up-regulation of leukaemia inhibitory factor and interleukin-6 in transected sciatic nerve and muscle following denervation

1996 • 160 citations

Ectopic adrenergic sensitivity in damaged peripheral nerve axons in the rat

1981 • 160 citations

Rapid sprouting of sympathetic axons in dorsal root ganglia of rats with a chronic constriction injury

1997 • 156 citations

Phenoxybenzamine in the treatment of causalgia

1984 • 151 citations

Expression of α₂‐adrenergic receptors in rat primary afferent neurones after peripheral nerve injury or inflammation

1999 • 145 citations

Neurotrophic factors and their receptors in human sensory neuropathies

2004 • 144 citations

PRELIMINARY OBSERVATIONS ON THE PATHOPHYSIOLOGY OF HYPERALGESIA IN THE CAUSALGIC PAIN SYNDROME

1976 • 136 citations

An experimental painful peripheral neuropathy due to nerve constriction

1992 • 129 citations

Increased NGF mRNA expression in denervated rat skin

1993 • 111 citations

Comparison of sympathetic sprouting in sensory ganglia in three animal models of neuropathic pain

1998 • 106 citations

Ectopic discharge in injured nerves: comparison of trigeminal and somatic afferent

1992 • 104 citations

Lumbar sympathectomy failed to reverse mechanical allodynia- and hyperalgesia-like behavior in rats with L5 spinal nerve injury

1999 • 94 citations

Sympathetic nerves in adult rats regenerate normally and restore pilomotor function during an anti‐NGF treatment that prevents their collateral sprouting

1992 • 89 citations

Sympathetic modulation of activity in rat dorsal root ganglion neurons changes over time following peripheral nerve injury

1996 • 89 citations

Receptor Subtype Mediating the Adrenergic Sensitivity of Pain Behavior and Ectopic Discharges in Neuropathic Lewis Rats

1999 • 86 citations

Glial overexpression of NGF enhances neuropathic pain and adrenergic sprouting into DRG following chronic sciatic constriction in mice

1998 • 82 citations

Autonomic fibre sprouting and changes in nociceptive sensory innervation in the rat lower lip skin following chronic constriction injury

2005 • 80 citations

Sprouting sympathetic fibers form synaptic varicosities in the dorsal root ganglion of the rat with neuropathic injury

1997 • 75 citations

Sympathetic nervous system: contribution to chronic pain.

2000 • 66 citations

Peripheral nerve injury leads to the establishment of a novel pattern of sympathetic fibre innervation in the rat skin

2000 • 64 citations

Sympathetic nervous system: contribution to chronic pain

2000 • 61 citations

Epidermal innervation density after partial sciatic nerve lesion and pain-related behavior in the rat

2002 • 59 citations

Adrenergic sensitivity of the sensory receptors modulating mechanical allodynia in a rat neuropathic pain model

1999 • 56 citations

Clinical trial of propranolol in post-traumatic neuralgia

1982 • 55 citations

Sympathetic Modulation of Activity in Aδ- and C-Primary Nociceptive Afferents After Intradermal Injection of Capsaicin in Rats

2004 • 52 citations

Effects of nerve injury on sympathetic excitation of A delta mechanical nociceptors

1995 • 49 citations

Leukemia inhibitory factor induces sympathetic sprouting in intact dorsal root ganglia in the adult rat in vivo

1998 • 48 citations

Intrathecal Neostigmine, but Not Sympathectomy, Relieves Mechanical Allodynia in a Rat Model of Neuropathic Pain

1998 • 48 citations

Cutaneous Nerve Terminal Degeneration in Painful Mononeuropathy

2001 • 42 citations

Peripheral norepinephrine exacerbates neuritis-induced hyperalgesia

2003 • 42 citations

Neuropathic pain in the orofacial region: clinical and research challenges.

2004 • 42 citations

Effects of purinergic and adrenergic antagonists in a rat model of painful peripheral neuropathy

2000 • 40 citations

Anti-NGF treatment blocks the upregulation of NGF receptor mRNA expression associated with collateral sprouting of rat dorsal root ganglion neurons

1995 • 38 citations

Norepinephrine Rekindles Mechanical Allodynia in Sympathectomized Neuropathic Rat

1995 • 38 citations

Abnormal contralateral pain responses from an intradermal injection of phenylephrine in a subset of patients with complex regional pain syndrome (CRPS)

2004 • 38 citations

Sympathetic-sensory coupling after L5 spinal nerve lesion in the rat and its relation to changes in dorsal root ganglion blood flow

2000 • 37 citations

Over-expression of NGF in skin causes formation of novel sympathetic projections to trkA-positive sensory neurons

1998 • 35 citations

The Effects of NGF and Sensory Nerve Stimulation on Collateral Sprouting and Gene Expression in Adult Sensory Neurons

1998 • 35 citations

Catecholamine-induced mechanical sensitization of cutaneous nociceptors in the rat

1994 • 34 citations

Differences between the Lewis and Sprague–Dawley rats in chronic inflammation induced norepinephrine sensitivity of cutaneous C-fiber nociceptors

2001 • 31 citations

The influence of chemical sympathectomy on pain responsivity and α2-adrenergic antinociception in neuropathic animals

2002 • 29 citations

The role of uninjured nerve in spinal nerve ligated rats points to an improved animal model of neuropathic pain

2003 • 26 citations

NGF‐dependent and NGF‐independent recovery of sympathetic function after chemical sympathectomy with 6‐hydroxydopamine

1995 • 24 citations

The effect of lumbar sympathectomy on increased tactile sensitivity in spinal nerve ligated rats

2001 • 17 citations

Production and immunocytochemical application of a highly sensitive and specific monoclonal antibody against rat dopamine-?-hydroxylase

1991 • 15 citations

Ultrastructural localization of sympathetic axons in experimental rat sciatic nerve neuromas

1996 • 14 citations

Extent of collateral sprouting of intact nerve fibers in rats depends on the local availability of nerve growth factor.

1998 • 5 citations