A comparison of the potential role of the tetrodotoxin-insensitive sodium channels, PN3/SNS and NaN/SNS2, in rat models of chronic pain

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

1992 • 3,001 citations

A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons

1996 • 1,057 citations

Hyperalgesic agents increase a tetrodotoxin-resistant Na+ current in nociceptors.

1996 • 677 citations

PGE2 modulates the tetrodotoxin‐resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP‐protein kinase A cascade.

1996 • 548 citations

Differential properties of tetrodotoxin-sensitive and tetrodotoxin- resistant sodium channels in rat dorsal root ganglion neurons

1992 • 518 citations

Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons

1997 • 511 citations

Downregulation of Tetrodotoxin-Resistant Sodium Currents and Upregulation of a Rapidly Repriming Tetrodotoxin-Sensitive Sodium Current in Small Spinal Sensory Neurons after Nerve Injury

1997 • 509 citations

NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy

1998 • 501 citations

Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction

1992 • 452 citations

Characterization of TTX‐sensitive and TTX‐resistant sodium currents in small cells from adult rat dorsal root ganglia.

1993 • 427 citations

Structure and Function of a Novel Voltage-gated, Tetrodotoxin-resistant Sodium Channel Specific to Sensory Neurons

1996 • 424 citations

Properties of afferent nerve impulses originating from a neuroma

1974 • 422 citations

Distribution of the Tetrodotoxin-Resistant Sodium Channel PN3 in Rat Sensory Neurons in Normal and Neuropathic Conditions

1998 • 372 citations

Spinal sensory neurons express multiple sodium channel α-subunit mRNAs

1996 • 362 citations

Mutation of a new sodium channel gene, Scn8a, in the mouse mutant ‘motor endplate disease’

1995 • 313 citations

Na+ channel immunolocalization in peripheral mammalian axons and changes following nerve injury and neuroma formation

1993 • 312 citations

Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons

1998 • 281 citations

A Novel Tetrodotoxin-sensitive, Voltage-gated Sodium Channel Expressed in Rat and Human Dorsal Root Ganglia

1997 • 274 citations

Hyperexcitability at sites of nerve injury depends on voltage-sensitive Na+ channels

1994 • 268 citations

Signs of neuropathic pain depend on signals from injured nerve fibers in a rat model

1993 • 250 citations

Down-regulation of transcripts for Na channel α-SNS in spinal sensory neurons following axotomy

1996 • 238 citations

Contributions of injured and intact afferents to neuropathic pain in an experimental rat model

1996 • 235 citations

A novel, abundant sodium channel expressed in neurons and glia

1995 • 230 citations

A tetrodotoxin-resistant sodium current mediates inflammatory pain in the rat

1998 • 216 citations

Electrophysiological properties of sodium current subtypes in small cells from adult rat dorsal root ganglia

1998 • 201 citations

Sodium channel accumulation in humans with painful neuromas

1996 • 179 citations

5HT₄Receptors Couple Positively to Tetrodotoxin-Insensitive Sodium Channels in a Subpopulation of Capsaicin-Sensitive Rat Sensory Neurons

1997 • 170 citations

Kinetic analysis of two types of Na+ channels in rat dorsal root ganglia.

1993 • 161 citations

Glycosylation is required for maintenance of functional sodium channels in neuroblastoma cells.

1983 • 154 citations

Selective loss of slow and enhancement of fast Na+currents in cutaneous afferent dorsal root ganglion neurones following axotomy

1995 • 139 citations

NGF has opposing effects on Na+ channel III and SNS gene expression in spinal sensory neurons

1997 • 130 citations

Is large myelinated fiber loss associated with hyperalgesia in a model of experimental peripheral neuropathy in the rat?

1993 • 127 citations

Functional Analysis of a Voltage‐Gated Sodium Channel and Its Splice Variant from Rat Dorsal Root Ganglia

1998 • 118 citations

Neuronal growth factor regulation of two different sodium channel types through distinct signal transduction pathways

1993 • 117 citations

Expression of tetrodotoxin-resistant sodium channels in capsaicin-sensitive dorsal root ganglion neurons of adult rats

1995 • 94 citations

Differential up-regulation of sodium channel α- and β1-subunit mRNAs in cultured embryonic DRG neurons following exposure to NGF

1995 • 60 citations

Selective attenuation of μ-opioid receptor-mediated effects in rat sensory neurons by intrathecal administration of antisense oligodeoxynucleotides

1996 • 36 citations

Slow Na+ channel inactivation and bursting discharge in a simple model axon: implications for neuropathic pain

1997 • 25 citations

Selective blockade of peripheral delta opioid agonist induced antinociception by intrathecal administration of delta receptor antisense oligodeoxynucleotide

1996 • 24 citations