Mechanical hyperalgesia after an L5 ventral rhizotomy or an L5 ganglionectomy in the rat

Quantitative assessment of tactile allodynia in the rat paw

1994 • 6,953 citations

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

1988 • 5,129 citations

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

1992 • 3,001 citations

Spared nerve injury: an animal model of persistent peripheral neuropathic pain

2000 • 2,067 citations

Efficient Analysis of Experimental Observations

1980 • 2,012 citations

A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury

1990 • 1,819 citations

Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve

1987 • 1,000 citations

Painful neuropathy: altered central processing maintained dynamically by peripheral input

1992 • 770 citations

Cytokines, nerve growth factor and inflammatory hyperalgesia: the contribution of tumour necrosis factor α

1997 • 667 citations

Interleukin-1β as a potent hyperalgesic agent antagonized by a tripeptide analogue

1988 • 618 citations

Nerve Injury, Axonal Degeneration and Neural Regeneration: Basic Insights

1999 • 553 citations

Potent Analgesic Effects of GDNF in Neuropathic Pain States

2000 • 506 citations

Characterization of cytokine-induced hyperalgesia

1994 • 506 citations

Tumour necrosis factor-α induces ectopic activity in nociceptive primary afferent fibres

1997 • 506 citations

The Effect of Site and Type of Nerve Injury on Spinal Glial Activation and Neuropathic Pain Behavior

1999 • 435 citations

Tactile allodynia in the absence of C-fiber activation: altered firing properties of DRG neurons following spinal nerve injury

2000 • 433 citations

Early Onset of Spontaneous Activity in Uninjured C-Fiber Nociceptors after Injury to Neighboring Nerve Fibers

2001 • 409 citations

Interleukin-6-Mediated Hyperalgesia/Allodynia and Increased Spinal IL-6 Expression in a Rat Mononeuropathy Model

1996 • 366 citations

Schwann cells produce tumor necrosis factor alpha: expression in injured and non-injured nerves

1996 • 357 citations

Hyperalgesia in Experimental Neuropathy Is Dependent on the TNF Receptor 1

1998 • 299 citations

Ventral root avulsion: An experimental model of death of adult motor neurons

1994 • 293 citations

Mechanical and Thermal Hyperalgesia and Ectopic Neuronal Discharge After Chronic Compression of Dorsal Root Ganglia

1999 • 284 citations

Uninjured C-Fiber Nociceptors Develop Spontaneous Activity and α-Adrenergic Sensitivity Following L₆ Spinal Nerve Ligation in Monkey

1999 • 280 citations

Neurotrophins and hyperalgesia

1999 • 270 citations

Mechanical hyperalgesia after an L5 spinal nerve lesion in the rat is not dependent on input from injured nerve fibers

2000 • 269 citations

Signs of neuropathic pain depend on signals from injured nerve fibers in a rat model

1993 • 250 citations

Cytokine and growth factor immunohistochemical spinal profiles in two animal models of mononeuropathy

1997 • 247 citations

Depletion of macrophages reduces axonal degeneration and hyperalgesia following nerve injury

2000 • 237 citations

Contributions of injured and intact afferents to neuropathic pain in an experimental rat model

1996 • 235 citations

Painful mononeuropathy in C57BL/Wld mice with delayed Wallerian degeneration: differential effects of cytokine production and nerve regeneration on thermal and mechanical hypersensitivity

1998 • 234 citations

Nociceptive and inflammatory effects of subcutaneous TNF α

2000 • 234 citations

Role of peri-axonal inflammation in the development of thermal hyperalgesia and guarding behavior in a rat model of neuropathic pain

1995 • 219 citations

Spontaneous activity of axotomized afferent neurons after L5 spinal nerve injury in rats

2000 • 204 citations

Axotomized and Intact Muscle Afferents But No Skin Afferents Develop Ongoing Discharges of Dorsal Root Ganglion Origin after Peripheral Nerve Lesion

2000 • 204 citations

Possible chemical contribution from chromic gut sutures produces disorders of pain sensation like those seen in man

1993 • 197 citations

Differential Expression of the p75 Nerve Growth Factor Receptor in Glia and Neurons of the Rat Dorsal Root Ganglia after Peripheral Nerve Transection

1996 • 193 citations

Cutaneous hyperalgesia induced by peripheral injection of interleukin-1β in the rat

1994 • 193 citations

Neutralizing antibodies to interleukin 1-receptor reduce pain associated behavior in mice with experimental neuropathy

1999 • 186 citations

Spinal nerve lesion-induced mechanoallodynia and adrenergic sprouting in sensory ganglia are attenuated in interleukin-6 knockout mice

1998 • 172 citations

Discharge pattern of afferent fibers from a neuroma

1984 • 170 citations

Wallerian degeneration is required for both neuropathic pain and sympathetic sprouting into the DRG

1997 • 167 citations

Duration of synthesis phase in neurilemma cells in mouse sciatic nerve during degeneration

1970 • 167 citations

Effect of NGF and anti-NGF on neuropathic pain in rats following chronic constriction injury of the sciatic nerve

1999 • 156 citations

Serial Determination of Tumor Necrosis Factor-Alpha Content in Rat Sciatic Nerve after Chronic Constriction Injury

1999 • 152 citations

NGF involvement in pain induced by chronic constriction injury of the rat sciatic nerve

1997 • 149 citations

Pain due to nerve damage: Are inflammatory mediators involved

1995 • 145 citations

Intracerebroventricular injection of interleukin-1β induces hyperalgesia in rats

1993 • 142 citations

Prolonged survival of transected nerve fibres in C57BL/Ola mice is an intrinsic characteristic of the axon

1993 • 140 citations

Hyperalgesia due to nerve damage: role of nerve growth factor

1999 • 132 citations

Nerve growth factor induced hyperalgesia in the rat hind paw is dependent on circulating neutrophils

1998 • 127 citations

Intracerebroventricular injection of interleukin-6 induces thermal hyperalgesia in rats

1995 • 127 citations

Reduced Hyperalgesia in Nerve-Injured WLD Mice: Relationship to Nerve Fiber Phagocytosis, Axonal Degeneration, and Regeneration in Normal Mice

1996 • 124 citations

Neural activity originating from a neuroma in the baboon

1985 • 122 citations

Low dose of tetrodotoxin reduces neuropathic pain behaviors in an animal model

2000 • 116 citations

Inflammation of the rat urinary bladder is associated with a referred thermal hyperalgesia which is nerve growth factor dependent

1999 • 115 citations

Interleukin-1 activity in lesioned peripheral nerve

1992 • 114 citations

Axons modulate the expression of transforming growth factor‐betas in Schwann cells

1993 • 107 citations

Effects of neutralizing antibodies to TNF-alpha on pain-related behavior and nerve regeneration in mice with chronic constriction injury

2000 • 103 citations

Dermatome mapping in the rat hindlimb by electrical stimulation of the spinal nerves

1994 • 94 citations

Lumbar sympathectomy failed to reverse mechanical allodynia- and hyperalgesia-like behavior in rats with L5 spinal nerve injury

1999 • 94 citations

Inflammatory Mediators Sensitize Acutely Axotomized Nerve Fibers to Mechanical Stimulation in the Rat

1998 • 87 citations

Receptor Subtype Mediating the Adrenergic Sensitivity of Pain Behavior and Ectopic Discharges in Neuropathic Lewis Rats

1999 • 86 citations

Nerve growth factor evokes hyperalgesia in mice lacking the low-affinity neurotrophin receptor p75

1998 • 86 citations

Glial overexpression of NGF enhances neuropathic pain and adrenergic sprouting into DRG following chronic sciatic constriction in mice

1998 • 82 citations

Local injection of nerve growth factor (NGF) triggers degranulation of mast cells in rat paw

1997 • 81 citations

Dorsal root section elicits signs of neuropathic pain rather than reversing them in rats with L5 spinal nerve injury

2000 • 78 citations

Ion channels associated with the ectopic discharges generated after segmental spinal nerve injury in the rat

2001 • 71 citations

Behavioral manifestations of neuropathic pain and mechanical allodynia, and changes in spinal dorsal horn neurons, following L4–L6 dorsal root constriction in rats

1999 • 71 citations

Signals for proinflammatory cytokine secretion by human Schwann cells

1999 • 71 citations

Limited role of macrophages in generation of nerve injury-induced mechanical allodynia

2000 • 66 citations

Unmyelinated and small myelinated axons in rat ventral roots

1977 • 61 citations

Sensory and Motor Denervation Influence Epidermal Thickness in Rat Foot Glabrous Skin

1997 • 60 citations

Ectopic excitability of injured nerves in monkey: entrained responses to vibratory stimuli

1991 • 56 citations

Mechanical sensitivity of regenerating myelinated skin and muscle afferents in the cat

1995 • 40 citations

Hyperalgesia and upregulation of cytokines and nerve growth factor by cutaneous leishmaniasis in mice

2000 • 38 citations

New Method for the Study of the Nervous System

1852 • 28 citations

Cold Blockade of Axonal Transport Activates Premitotic Activity of Schwann Cells and Wallerian Degeneration

1988 • 25 citations

Inhibition of peripheral interleukin-10-induced hyperalgesia by the intracerebroventricular administration of diclofenac and α-melanocyte-stimulating hormone

1996 • 21 citations

Delayed response to denervation in muscles of C57BL/Ola mice

1991 • 21 citations