Back to search

Anti-hyperalgesic and morphine-sparing actions of propentofylline following peripheral nerve injury in rats: mechanistic implications of spinal glia and proinflammatory cytokines

Data up to Jan 2025

Published2003
Citations205
References49

Total Citations Per Year

Abstract

References (49)

Microglia: a sensor for pathological events in the CNS

1996 • 4,309 citations

Glial activation: a driving force for pathological pain

2001 • 1,062 citations

Pathobiology of neuropathic pain

2001 • 929 citations

Microglia as neuroprotective, immunocompetent cells of the CNS

2002 • 909 citations

The role of neuroinflammation and neuroimmune activation in persistent pain

2001 • 639 citations

Characterization of cytokine-induced hyperalgesia

1994 • 506 citations

Adenosine receptor activation and nociception

1998 • 478 citations

The Effect of Site and Type of Nerve Injury on Spinal Glial Activation and Neuropathic Pain Behavior

1999 • 435 citations

Traumatic spinal cord injury induces nuclear factor-kappaB activation.

1998 • 434 citations

The Role of Spinal Neuroimmune Activation in Morphine Tolerance/Hyperalgesia in Neuropathic and Sham-Operated Rats

2002 • 412 citations

The involvement of glial cells in the development of morphine tolerance

2001 • 394 citations

Traumatic Spinal Cord Injury Induces Nuclear Factor-κB Activation

1998 • 379 citations

Spinal cord glia: new players in pain

2001 • 354 citations

Intrathecal interleukin-1 receptor antagonist in combination with soluble tumor necrosis factor receptor exhibits an anti-allodynic action in a rat model of neuropathic pain

2001 • 345 citations

Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat

1997 • 345 citations

Time-Dependent Descending Facilitation from the Rostral Ventromedial Medulla Maintains, But Does Not Initiate, Neuropathic Pain

2002 • 343 citations

The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat

1994 • 340 citations

Intrathecal HIV-1 Envelope Glycoprotein gp120 Induces Enhanced Pain States Mediated by Spinal Cord Proinflammatory Cytokines

2001 • 320 citations

Pronociceptive Actions of Dynorphin Maintain Chronic Neuropathic Pain

2001 • 299 citations

Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain.

2001 • 265 citations

Spinal and Supraspinal Mechanisms of Neuropathic Pain

2000 • 259 citations

Anti-inflammatory interleukin-10 therapy in CCI neuropathy decreases thermal hyperalgesia, macrophage recruitment, and endoneurial TNF-α expression

1998 • 250 citations

Intrinsic mechanisms of antinociception in inflammation: local opioid receptors and beta-endorphin

1990 • 228 citations

Ethical standards for investigations of experimental pain in animals

1980 • 166 citations

Cyclic adenosine monophosphate-responsive elements are involved in the transcriptional activation of the human IL-10 gene in monocytic cells

1999 • 161 citations

Cytokine involvement in dynorphin-induced allodynia

2000 • 153 citations

Effect of propentofylline (HWA 285) on extracellular purines and excitatory amino acids in CA1 of rat hippocampus during transient ischaemia

1990 • 143 citations

Cascading Glia Reactions: a Common Pathomechanism and Its Differentiated Control by Cyclic Nucleotide Signaling

2000 • 129 citations

Pharmacology of opioid and nonopioid analgesics in chronic pain states.

2001 • 123 citations

Phosphodiesterase inhibitory profile of some related xanthine derivatives pharmacologically active on the peripheral microcirculation

1994 • 101 citations

Exogenous and endogenous adenosine enhance the spinal antiallodynic effects of morphine in a rat model of neuropathic pain

1999 • 96 citations

Stimulation of nerve growth factor synthesis/secretion by propentofylline in cultured mouse astroglial cells

1990 • 89 citations

Loss of antiallodynic and antinociceptive spinal/supraspinal morphine synergy in nerve-injured rats: restoration by MK-801 or dynorphin antiserum

1999 • 88 citations

Adenosine and Propentofylline Inhibit the Proliferation of Cultured Microglial Cells

1996 • 83 citations

Differential regulation of microglial activation by propentofylline via cAMP signaling

1998 • 81 citations

Inhibitors of acyl-coenzyme A:lysolecithin acyltransferase activate the production of endothelium-derived vascular relaxing factor.

1986 • 80 citations

Methods in Pain Research

2001 • 78 citations

Adenosine and neuropathic pain

1996 • 74 citations

Adjuvant-induced arthritis: IL-1β, IL-6 and TNF-α are up-regulated in the spinal cord

2001 • 70 citations

The effect of pentoxifiline on post-injury hyperalgesia in rats and postoperative pain in patients

2000 • 68 citations

Support of Homeostatic Glial Cell Signaling: A Novel Therapeutic Approach by Propentofyllinea

1997 • 52 citations

An adenosine uptake blocker, propentofylline, reduces glutamate release in gerbil hippocampus following transient forebrain ischemia

1992 • 48 citations

Inhibitory effects of propentofylline on [3H]adenosine influx

1993 • 48 citations

Propentofylline in the treatment of vascular dementia and Alzheimer-type dementia: overview of phase I and phase II clinical trials.

1998 • 46 citations

Morphine-induced Spinal Release of Adenosine Is Reduced in Neuropathic Rats

2001 • 42 citations

Proinflammatory cytokines and glial cells: Their role in neuropathic pain

1999 • 31 citations

Confluence of antianalgesic action of diverse agents through brain interleukin(1beta) in mice.

2001 • 20 citations

Propentofylline in the Treatment of Vascular Dementia and Alzheimer-Type Dementia

1998 • 18 citations

The Cytokine Challenge

2001 • 6 citations

Cited By (0)

Loading...
Anti-hyperalgesic and morphine-sparing actions of propentofylline following peripheral… (2003) – Pain | Metascience Observatory Explorer