GRAIL Is Up-regulated in CD4+ CD25+ T Regulatory Cells and Is Sufficient for Conversion of T Cells to a Regulatory Phenotype

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Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

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An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

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Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

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Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Inducing and expanding regulatory T cell populations by foreign antigen

2005 • 1,245 citations

TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

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JM2, encoding a fork head–related protein, is mutated in X-linked autoimmunity–allergic disregulation syndrome

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In Vivo Instruction of Suppressor Commitment in Naive T Cells

2004 • 726 citations

TGF-β1 Plays an Important Role in the Mechanism of CD4+CD25+ Regulatory T Cell Activity in Both Humans and Mice

2004 • 643 citations

CD4+CD25+ Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor β1 Production and Responsiveness

2002 • 614 citations

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

2004 • 512 citations

Generation of Anergic and Potentially Immunoregulatory CD25+CD4 T Cells In Vivo After Induction of Peripheral Tolerance with Intravenous or Oral Antigen

2001 • 429 citations

Distinct roles of CTLA‐4 and TGF‐β in CD4⁺CD25⁺ regulatory T cell function

2004 • 377 citations

Nature's TRAIL—On a Path to Cancer Immunotherapy

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Induction of T helper type 1–like regulatory cells that express Foxp3 and protect against airway hyper-reactivity

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GRAIL

2003 • 280 citations

CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation

2002 • 219 citations

Direct Evidence That Functionally Impaired CD4+ T Cells Persist In Vivo Following Induction of Peripheral Tolerance

1998 • 196 citations

Two isoforms of otubain 1 regulate T cell anergy via GRAIL

2003 • 168 citations

T-cell Clonal Anergy

1989 • 163 citations

The Amount of Scurfin Protein Determines Peripheral T Cell Number and Responsiveness

2001 • 152 citations

Effectiveness of Lipid and Lipidophilic Substances as Adjuvants

1961 • 148 citations

CD4+CD25+ T Cells Facilitate the Induction of T Cell Anergy

2001 • 137 citations

Adaptive Tolerance of CD4+ T Cells In Vivo: Multiple Thresholds in Response to a Constant Level of Antigen Presentation

2001 • 124 citations

Targeting Rare Populations of Murine Antigen-Specific T Lymphocytes by Retroviral Transduction for Potential Application in Gene Therapy for Autoimmune Disease

2000 • 108 citations

The Gene Related to Anergy in Lymphocytes, an E3 Ubiquitin Ligase, Is Necessary for Anergy Induction in CD4 T Cells

2004 • 99 citations

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