What's new in the Aire?

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Positional cloning of the APECED gene

1997 • 1,385 citations

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

1997 • 1,155 citations

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

2001 • 1,043 citations

Nuclear speckles: a model for nuclear organelles

2003 • 955 citations

The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

1997 • 931 citations

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

1997 • 806 citations

Aire regulates negative selection of organ-specific T cells

2003 • 789 citations

A CENTRAL ROLE FOR CENTRAL TOLERANCE

2006 • 730 citations

The Cellular Mechanism of Aire Control of T Cell Tolerance

2005 • 622 citations

Antigen-dependent Proliferation of CD4+ CD25+ Regulatory T Cells In Vivo

2003 • 600 citations

Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells

2007 • 562 citations

Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy

2006 • 561 citations

Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

2005 • 540 citations

Central Tolerance to Tissue-specific Antigens Mediated by Direct and Indirect Antigen Presentation

2004 • 474 citations

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

2002 • 463 citations

Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells

2006 • 443 citations

Major Histocompatibility Complex Class II–Positive Cortical Epithelium Mediates the Selection of Cd4+25+ Immunoregulatory T Cells

2001 • 406 citations

Formation of a functional thymus initiated by a postnatal epithelial progenitor cell

2006 • 381 citations

Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters

2004 • 352 citations

Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self

2006 • 346 citations

Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium

2006 • 331 citations

Gene Dosage–limiting Role ofAirein Thymic Expression, Clonal Deletion, and Organ-specific Autoimmunity

2004 • 291 citations

Development of Autoimmunity against Transcriptionally Unrepressed Target Antigen in the Thymus of Aire-Deficient Mice

2005 • 287 citations

Spontaneous autoimmunity prevented by thymic expression of a single self-antigen

2006 • 271 citations

Identification and Characterization of Thymic Epithelial Progenitor Cells

2002 • 269 citations

Normal Thymic Architecture and Negative Selection Are Associated with Aire Expression, the Gene Defective in the Autoimmune-Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED)

2000 • 261 citations

The coactivator LXXLL nuclear receptor recognition motif

2004 • 261 citations

The Nuclear Dot Protein Sp100, Characterization of Domains Necessary for Dimerization, Subcellular Localization, and Modification by Small Ubiquitin-like Modifiers

1999 • 258 citations

The Autoimmune Regulator Protein Has Transcriptional Transactivating Properties and Interacts with the Common Coactivator CREB-binding Protein

2000 • 239 citations

APS-I/APECED: the clinical disease and therapy

2002 • 236 citations

Modifier loci condition autoimmunity provoked by Aire deficiency

2005 • 233 citations

Aldehydes in Exhaled Breath Condensate of Patients with Chronic Obstructive Pulmonary Disease

2003 • 227 citations

Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin

2007 • 207 citations

Genetics of autoimmune diseases — disorders of immune homeostasis

2006 • 194 citations

Lymphotoxin pathway directs thymic Aire expression

2003 • 193 citations

Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling

1999 • 173 citations

The Autoimmune Regulator (AIRE) Is a DNA-binding Protein

2001 • 172 citations

AIRE Functions As an E3 Ubiquitin Ligase

2004 • 145 citations

NF-κB2 is required for the establishment of central tolerance through an Aire-dependent pathway

2006 • 128 citations

Chromosomal clustering of genes controlled by the aire transcription factor

2005 • 126 citations

Aire-Dependent Alterations in Medullary Thymic Epithelium Indicate a Role for Aire in Thymic Epithelial Differentiation

2007 • 126 citations

AIRE and APECED: molecular insights into an autoimmune disease

2005 • 124 citations

Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice

2006 • 117 citations

How defects in central tolerance impinge on a deficiency in regulatory T cells

2005 • 117 citations

Aire: an update

2004 • 102 citations

Subcellular Location and Expression Pattern of Autoimmune Regulator (Aire), the Mouse Orthologue for Human Gene Defective in Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED)

2001 • 97 citations

The Expression of Autoimmune Polyglandular Disease Type I Appears Associated With Several HLA-A Antigens But Not With HLA-DR*

1988 • 93 citations

NMR Structure of the First PHD Finger of Autoimmune Regulator Protein (AIRE1)

2005 • 89 citations

Increased antigen presenting cell‐mediated T cell activation in mice and patients without the autoimmune regulator

2006 • 81 citations

Features of Medullary Thymic Epithelium Implicate Postnatal Development in Maintaining Epithelial Heterogeneity and Tissue-Restricted Antigen Expression

2006 • 79 citations

The MouseAireGene: Comparative Genomic Sequencing, Gene Organization, and Expression

1999 • 78 citations

Highly variable expression of tissue‐restricted self‐antigens in human thymus: Implications for self‐tolerance and autoimmunity

2007 • 72 citations

Subcellular Expression of Autoimmune Regulator Is Organized in a Spatiotemporal Manner

2004 • 71 citations

Exhaled carbon monoxide is not elevated in patients with asthma or cystic fibrosis

2002 • 70 citations

Isolation and Characterization of the MouseAireGene

1999 • 68 citations

Contrasting models of promiscuous gene expression by thymic epithelium

2005 • 67 citations

Linking signalling pathways, thymic stroma integrity and autoimmunity

2005 • 60 citations

Biological monitoring in occupational and environmental toxicology

1999 • 47 citations

Mapping DNA-binding domains of the autoimmune regulator protein

2004 • 46 citations

A comparative study of mRNA and protein expression of the autoimmune regulator gene (Aire) in embryonic and adult murine tissues

2004 • 41 citations

Lessons on immune tolerance from the monogenic disease APS1

2007 • 27 citations

Exhaled biomarkers in COPD: their potential role in diagnosis, treatment and prognosis.

2003 • 16 citations