The E3 Ubiquitin Ligase Itch Couples JNK Activation to TNFα-induced Cell Death by Inducing c-FLIPL Turnover

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

A Third-Generation Lentivirus Vector with a Conditional Packaging System

1998 • 3,175 citations

NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation

1998 • 2,698 citations

NF-κB at the crossroads of life and death

2002 • 2,684 citations

Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes

2003 • 2,545 citations

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

Tumor necrosis factor signaling

2003 • 2,262 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

2005 • 1,727 citations

CD95's deadly mission in the immune system

2000 • 1,714 citations

The proteasome: a suitable antineoplastic target

2004 • 1,189 citations

A T cell-dependent experimental liver injury in mice inducible by concanavalin A.

1992 • 1,041 citations

Ubiquitin Protein Ligase Activity of IAPs and Their Degradation in Proteasomes in Response to Apoptotic Stimuli

2000 • 989 citations

Mule/ARF-BP1, a BH3-Only E3 Ubiquitin Ligase, Catalyzes the Polyubiquitination of Mcl-1 and Regulates Apoptosis

2005 • 802 citations

NF-κB Signals Induce the Expression of c-FLIP

2001 • 799 citations

Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling

2001 • 725 citations

Inhibition of JNK activation through NF-κB target genes

2001 • 720 citations

A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia

2003 • 656 citations

Ferritin Heavy Chain Upregulation by NF-κB Inhibits TNFα-Induced Apoptosis by Suppressing Reactive Oxygen Species

2004 • 625 citations

Cellular FLICE-inhibitory Protein Splice Variants Inhibit Different Steps of Caspase-8 Activation at the CD95 Death-inducing Signaling Complex

2001 • 563 citations

A JNK-Dependent Pathway Is Required for TNFα-Induced Apoptosis

2003 • 557 citations

FLICE-Inhibitory Proteins: Regulators of Death Receptor-Mediated Apoptosis

2001 • 550 citations

Requirement for Casper (c-FLIP) in Regulation of Death Receptor–Induced Apoptosis and Embryonic Development

2000 • 509 citations

Macrophage Apoptosis by Anthrax Lethal Factor Through p38 MAP Kinase Inhibition

2002 • 499 citations

Tumor Necrosis Factor

2004 • 491 citations

Galactosamine hepatitis: Key role of the nucleotide deficiency period in the pathogenesis of cell injury and cell death

2005 • 441 citations

Jun Turnover Is Controlled Through JNK-Dependent Phosphorylation of the E3 Ligase Itch

2004 • 386 citations

Regulation of lymphocyte proliferation and death by flip

2001 • 385 citations

JNK1 Is Required for Maintenance of Neuronal Microtubules and Controls Phosphorylation of Microtubule-Associated Proteins

2003 • 368 citations

Life And Death Decisions

2004 • 337 citations

Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation

2002 • 326 citations

IKKβ Is Required for Prevention of Apoptosis Mediated by Cell-Bound but Not by Circulating TNFα

2003 • 288 citations

c-FLIPR, a New Regulator of Death Receptor-induced Apoptosis

2005 • 275 citations

Linking JNK signaling to NF-κB: a key to survival

2004 • 266 citations

c-Jun N-Terminal Protein Kinase 1 (JNK1), but Not JNK2, Is Essential for Tumor Necrosis Factor Alpha-Induced c-Jun Kinase Activation and Apoptosis

2004 • 200 citations

The ubiquitin system: pathogenesis of human diseases and drug targeting

2004 • 158 citations

Up-regulation of c-FLIPshort and reduction of activation-induced cell death in CD28-co-stimulated human T cells

2000 • 153 citations

TCR-Mediated Up-Regulation of c-FLIPshort Correlates with Resistance Toward CD95-Mediated Apoptosis by Blocking Death-Inducing Signaling Complex Activity

2000 • 141 citations

Itch E3 Ligase-Mediated Regulation of TGF-β Signaling by Modulating Smad2 Phosphorylation

2004 • 116 citations

The JNKK2-JNK1 Fusion Protein Acts As a Constitutively Active c-Jun Kinase That Stimulates c-Jun Transcription Activity

1999 • 110 citations