The ubiquitin–protein ligase Itch regulates p73 stability

Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human Cancers

1997 • 1,636 citations

Themes and variations on ubiquitylation

2001 • 1,475 citations

Protein regulation by monoubiquitin

2001 • 1,195 citations

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

2000 • 979 citations

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the δ domain

1994 • 930 citations

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

1999 • 914 citations

Antigen processing by the proteasome

2001 • 620 citations

p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

1999 • 584 citations

p73: Friend or foe in tumorigenesis

2002 • 546 citations

Interaction of c-Abl and p73α and their collaboration to induce apoptosis

1999 • 542 citations

Physical Interaction with Yes-associated Protein Enhances p73 Transcriptional Activity

2001 • 407 citations

Two New p73 Splice Variants, γ and δ, with Different Transcriptional Activity

1998 • 363 citations

p73 Induces Apoptosis via PUMA Transactivation and Bax Mitochondrial Translocation

2004 • 358 citations

Human ΔNp73 regulates a dominant negative feedback loop for TAp73 and p53

2001 • 335 citations

MDM2 Suppresses p73 Function without Promoting p73 Degradation

1999 • 329 citations

The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

1998 • 328 citations

Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation

2002 • 326 citations

Recognition and Ubiquitination of Notch by Itch, a Hect-type E3 Ubiquitin Ligase

2000 • 321 citations

ΔNp73, A Dominant-Negative Inhibitor of Wild-type p53 and TAp73, Is Up-regulated in Human Tumors

2002 • 317 citations

Structure and function of the WW domain

1996 • 290 citations

Functional regulation of p73 and p63: development and cancer

2003 • 278 citations

A ribonucleotide reductase gene is a transcriptional target of p53 and p73

2000 • 228 citations

Mdm2 binds p73α without targeting degradation

1999 • 206 citations

Nedd4-like proteins: an emerging family of ubiquitin-protein ligases implicated in diverse cellular functions

1999 • 199 citations

Induction of Neuronal Differentiation by p73 in a Neuroblastoma Cell Line

2000 • 184 citations

Expression of ΔNp73 is a molecular marker for adverse outcome in neuroblastoma patients

2002 • 179 citations

Latent Membrane Protein 2A of Epstein-Barr Virus Binds WW Domain E3 Protein-Ubiquitin Ligases That Ubiquitinate B-Cell Tyrosine Kinases

2000 • 171 citations

Inactivation of the p53-homologue p73 by the mdm2-oncoprotein

1999 • 161 citations

Role of p73 in malignancy: tumor suppressor or oncogene?

2002 • 153 citations

Physical Interaction between Specific E2 and Hect E3 Enzymes Determines Functional Cooperativity

1997 • 150 citations

New p73 variants with altered C-terminal structures have varied transcriptional activities

1999 • 147 citations

p53 family genes: structural comparison, expression and mutation

1999 • 144 citations

MDM2 and MDMX bind and stabilize the p53-related protein p73

1999 • 132 citations

Ubiquitin-dependent Degradation of p73 Is Inhibited by PML

2004 • 115 citations

A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity

2003 • 91 citations

Regulation and activation of p53 and its family members

1999 • 89 citations

DN-p73 is activated after DNA damage in a p53-dependent manner to regulate p53-induced cell cycle arrest

2002 • 74 citations

c-Jun Regulates the Stability and Activity of the p53 Homologue, p73

2004 • 73 citations

Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 111Edited by J. Karn

2001 • 66 citations

Enhanced p73 Expression during Differentiation and Complex p73 Isoforms in Myeloid Leukemia

2000 • 63 citations

Alternative Bacteriophage Display Systems

2012 • 54 citations

Nuclear Import/Export of hRPF1/Nedd4 Regulates the Ubiquitin- dependent Degradation of Its Nuclear Substrates

2001 • 51 citations

Ascorbate up-regulates MLH1 (Mut L homologue-1) and p73: implications for the cellular response to DNA damage

2002 • 50 citations

Phage Displayed Peptide Libraries

1999 • 31 citations

Biological and clinical role of p73 in neuroblastoma

2003 • 18 citations

p73: in silico evidence for a putative third promoter region

2003 • 14 citations

Polyomavirus Large T Antigen Induces Alterations in Cytoplasmic Signalling Pathways Involving Shc Activation

1999 • 11 citations