Inositol Lipids and Signal Transduction in the Nervous System: An Update

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands

1982 • 2,148 citations

Identification of a Family of Muscarinic Acetylcholine Receptor Genes

1987 • 1,439 citations

Is there a basis for distinguishing two types of P2-purinoceptor?

1985 • 1,353 citations

CELL-SURFACE ANCHORING OF PROTEINS VIA GLYCOSYL-PHOSPHATIDYLINOSITOL STRUCTURES

1988 • 1,284 citations

Sequence and expression of a metabotropic glutamate receptor

1991 • 1,200 citations

The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain.

1980 • 1,099 citations

Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400

1989 • 1,039 citations

Studies of Inositol Phospholipid-Specific Phospholipase C

1989 • 914 citations

Regulation of Polyphosphoinositide-specific Phospholipase C Activity by Purified G _q

1991 • 886 citations

Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes

1988 • 792 citations

Activation of the β1 isozyme of phospholipase C by α subunits of the Gq class of G proteins

1991 • 774 citations

Solubilization, purification, and characterization of an inositol trisphosphate receptor.

1988 • 650 citations

Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils.

1990 • 615 citations

Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness.

1990 • 567 citations

Alpha 1-adrenergic receptor subtypes, inositol phosphates, and sources of cell Ca2+.

1988 • 566 citations

Putative receptor for inositol 1,4,5-trisphosphate similar to ryanodine receptor

1989 • 531 citations

Cloning, Expression, and Gene Structure of a G Protein-Coupled Glutamate Receptor from Rat Brain

1991 • 524 citations

Purified inositol 1,4,5-trisphosphate receptor mediates calcium flux in reconstituted lipid vesicles

1989 • 512 citations

Site of G Protein Binding to Rhodopsin Mapped with Synthetic Peptides from the α Subunit

1988 • 491 citations

Endothelin in brain: receptors, mitogenesis, and biosynthesis in glial cells.

1990 • 480 citations

The Actin-Binding Protein Profilin Binds to PIP ₂ and Inhibits Its Hydrolysis by Phospholipase C

1990 • 472 citations

Structure and expression of the rat inositol 1,4,5-trisphosphate receptor.

1990 • 469 citations

Pharmacological and functional characteristics of metabotropic excitatory amino acid receptors

1990 • 464 citations

The aminosteroid U-73122 inhibits muscarinic receptor sequestration and phosphoinositide hydrolysis in SK-N-SH neuroblastoma cells. A role for Gp in receptor compartmentation.

1991 • 453 citations

Inositol 1,4,5-trisphosphate receptor localized to endoplasmic reticulum in cerebellar Purkinje neurons

1989 • 431 citations

Sarafotoxin, a Novel Vasoconstrictor Peptide: Phosphoinositide Hydrolysis in Rat Heart and Brain

1988 • 362 citations

Phosphatidylinositol is the membrane-anchoring domain of the Thy-1 glycoprotein

1985 • 355 citations

Receptor Activation and Inositol Lipid Hydrolysis in Neural Tissues

1987 • 341 citations

Pulsatile intracellular calcium release does not depend on fluctuations in inositol trisphosphate concentration

1989 • 338 citations

Phosphoinositide kinases

1990 • 331 citations

The inositol 1,4,5,-trisphosphate receptor in cerebellar Purkinje cells: quantitative immunogold labeling reveals concentration in an ER subcompartment.

1990 • 326 citations

Trans-ACPD, a selective agonist of the phosphoinositide-coupled excitatory amino acid receptor

1989 • 318 citations

Generation of Calcium Oscillations in Fibroblasts by Positive Feedback Between Calcium and IP ₃

1991 • 317 citations

Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation

1987 • 307 citations

Highly Cooperative Opening of Calcium Channels by Inositol 1,4,5-Trisphosphate

1988 • 307 citations

Metabolism of the inositol phosphates produced upon receptor activation

1989 • 305 citations

Structural and functional characterization of inositol 1,4,5-trisphosphate receptor channel from mouse cerebellum.

1991 • 299 citations

A saturable receptor for 32P-inositol-l,4,5-trisphosphate in hepatocytes and neutrophils

1986 • 296 citations

A cerebellar Purkinje cell marker P400 protein is an inositol 1,4,5-trisphosphate (InsP3) receptor protein. Purification and characterization of InsP3 receptor complex.

1990 • 280 citations

Glycosyl‐phosphatidylinositol: a versatile anchor for cell surface proteins ¹

1989 • 267 citations

Acetylcholine analogue stimulates DNA synthesis in brain-derived cells via specific muscarinic receptor subtypes

1989 • 254 citations

Increased brain myo-inositol 1-phosphate in lithium-treated rats

1976 • 252 citations

d-Myoinositol 1-Phosphate as Product of Cyclization of Glucose 6-Phosphate and Substrate for a Specific Phosphatase in Rat Testis

1967 • 252 citations

Second messengers involved in the mechanism of action of bradykinin in sensory neurons in culture

1989 • 249 citations

Inositol trisphosphate receptor localization in brain: variable stoichiometry with protein kinase C

1987 • 249 citations

Recent insights in phosphatidylinositol signaling

1990 • 245 citations

Purification and characterization of two immunologically distinct phosphoinositide-specific phospholipases C from bovine brain.

1987 • 243 citations

Polyphosphoinositides Produced by Phosphatidylinositol 3-Kinase Are Poor Substrates for Phospholipases C from Rat Liver and Bovine Brain

1989 • 238 citations

Inositol 1,4,5-trisphosphate receptors: distinct neuronal and nonneuronal forms derived by alternative splicing differ in phosphorylation.

1991 • 233 citations

Intracellular Ca2+ activates phospholipase C

1988 • 233 citations

Bovine brain cytosol contains three immunologically distinct forms of inositolphospholipid-specific phospholipase C.

1987 • 233 citations

myo‐Inositol metabolites as cellular signals

1990 • 227 citations

Evidence that the inositol phospholipids are necessary for exocytosis. Loss of inositol phospholipids and inhibition of secretion in permeabilized cells caused by a bacterial phospholipase C and removal of ATP

1990 • 227 citations

Autoradiographic visualization of the binding sites for [125I]endothelin in rat and human brain

1989 • 225 citations

Low Urinarychiro-Inositol Excretion in Non-Insulin-Dependent Diabetes Mellitus

1990 • 217 citations

Stimulation of a dopamine D1 receptor enhances inositol phosphates formation in rat brain.

1990 • 217 citations

Mass measurements of inositol(1,4,5)trisphosphate in rat cerebral cortex slices using a radioreceptor assay: Effects of neurotransmitters and depolarization

1988 • 217 citations

Subclassification of α₁‐adrenoceptor recognition sites by urapidil derivatives and other selective antagonists

1989 • 213 citations

Expression of striatal D1 dopamine receptors coupled to inositol phosphate production and Ca2+ mobilization in Xenopus oocytes.

1990 • 208 citations

Guanosine 5'-O-(thiotriphosphate)-dependent inositol trisphosphate formation in membranes is inhibited by phorbol ester and protein kinase C.

1987 • 203 citations

Calcium flux mediated by purified inositol 1,4,5-trisphosphate receptor in reconstituted lipid vesicles is allosterically regulated by adenine nucleotides.

1990 • 192 citations

Evidence for involvement of guanine nucleotide‐binding regulatory proteins in the activation of phospholipases by hormones

1988 • 190 citations

Occurrence and extracellular actions of inositol pentakis- and hexakisphosphate in mammalian brain

1987 • 190 citations

Diacylglycerol kinase: a key modulator of signal transduction?

1990 • 189 citations

Inositol 1,4,5-trisphosphate receptor

1993 • 178 citations

The purification and properties of myo-inositol monophosphatase from bovine brain

1988 • 174 citations

Characterization of a membrane protein from brain mediating the inhibition of inositol 1,4,5-trisphosphate receptor binding by calcium

1988 • 168 citations

Molecular recognition of inositol polyphosphates by intracellular receptors and metabolic enzymes

1989 • 163 citations

A Biochemical Correlate of the Critical Period for Synaptic Modification in the Visual Cortex

1989 • 163 citations

A Second Type of Rat Phosphoinositide-specific Phospholipase C Containing a src-related Sequence Not Essential for Phosphoinositide-hydrolyzing Activity

1989 • 160 citations

ATP‐Evoked Ca²⁺ Mobilisation and Prostanoid Release from Astrocytes: P₂‐Purinergic Receptors Linked to Phosphoinositide Hydrolysis

1989 • 156 citations

Heterogeneity of [3H]inositol 1,4,5-trisphosphate binding sites in adrenal-cortical membranes. Characterization and validation of a radioreceptor assay

1990 • 150 citations

Developmental expression and intracellular location of P400 protein characteristic of Purkinje cells in the mouse cerebellum

1989 • 145 citations

Lysergic acid diethylamide and 2,5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis.

1988 • 145 citations

Molecular Cloning and Expression of a Complementary DNA for Inositol 1,4,5-Trisphosphate 3-Kinase

1990 • 142 citations

Phosphatidylinositol 3-Phosphate Is Present in Normal and Transformed Fibroblasts and Is Resistant to Hydrolysis by Bovine Brain Phospholipase C II

1989 • 137 citations

Purification and characterization of bovine brain type I phosphatidylinositol kinase

1990 • 129 citations

Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+.

1987 • 128 citations

Nerve growth factor stimulates the hydrolysis of glycosylphosphatidylinositol in PC-12 cells: a mechanism of protein kinase C regulation.

1989 • 126 citations

DISTRIBUTION AND PROPERTIES OF CDP‐DIGLYCERIDE:INOSITOL TRANSFERASE FROM BRAIN¹

1969 • 126 citations

Bovine brain contains two types of phosphatidylinositol kinase

1987 • 125 citations

Inositol 1,4,5-trisphosphate receptor binding: autoradiographic localization in rat brain

1989 • 125 citations

Guanine nucleotides stimulate production of inositol trisphosphate in rat cortical membranes

1985 • 125 citations

Two different G-proteins mediate neuropeptide Y and bradykinin-stimulated phospholipid breakdown in cultured rat sensory neurons

1989 • 124 citations

Purification of phosphoinositide‐specific phospholipase C from a particulate fraction of bovine brain

1987 • 124 citations

Muscarinic receptor binding characteristics of a human neuroblastoma SK-N-SH and its clones SH-SY5Y and SH-EP1

1989 • 123 citations

Anatomical, physiological and biochemical studies on the cerebellum from mutant mice. III. Protein differences associated with the weaver, staggerer and nervous mutations

1976 • 122 citations

Lithium-induced reduction in intracellular inositol supply in cholinergically stimulated parotid gland

1986 • 121 citations

Evidence that inositol 1-phosphate in brain of lithium-treated rats results mainly from phosphatidylinositol metabolism

1987 • 121 citations

B-50 phosphorylation and polyphosphoinositide metabolism in nerve growth cone membranes

1988 • 119 citations

Synthesis of myo-inositol 1,3,4,5,6-pentakisphosphate from inositol phosphates generated by receptor activation

1988 • 118 citations

The interaction of lithium with thyrotropin-releasing hormone-stimulated lipid metabolism in GH3 pituitary tumour cells. Enhancement of stimulated 1,2-diacylglycerol formation

1984 • 116 citations

Phosphorylation of Phospholipase C-γ by cAMP-dependent Protein Kinase

1989 • 112 citations

Phospholipase C associated with particulate fractions of bovine brain.

1987 • 111 citations

Emerging functional roles for the glycosyl-phosphatidylinositol membrane protein anchor

1990 • 110 citations

A Novel Extracellular Nucleotide Receptor Coupled to Phosphoinositidase-C in Pituitary Cells*

1990 • 110 citations

Muscarinic receptor regulation of cytoplasmic Ca2+ concentrations in human SK-N-SH neuroblastoma cells: Ca2+ requirements for phospholipase C activation.

1989 • 110 citations

Subacute and Chronic In Vivo Lithium Treatment Inhibits Agonist‐ and Sodium Fluoride‐Stimulated Inositol Phosphate Production in Rat Cortex

1989 • 109 citations

Acute and chronic lithium treatments influence agonist and depolarization-stimulated inositol phospholipid hydrolysis in rat cerebral cortex.

1987 • 108 citations

Isolation and characterization of two different forms of inositol phospholipid-specific phospholipase C from rat brain.

1988 • 108 citations

Cloning and expression of bovine brain inositol monophosphatase.

1990 • 107 citations

Bradykinin Stimulates Phosphoinositide Hydrolysis and Mobilization of Arachidonic Acid in Dorsal Root Ganglion Neurons

1989 • 107 citations

(trans)-1-amino-cyclopentyl-1,3-dicarboxylate stimulates quisqualate phosphoinositide-coupled receptors but not ionotropic glutamate receptors in striatal neurons and Xenopus oocytes.

1990 • 105 citations

Purification of a phosphoinositide-specific phospholipase C from bovine brain.

1987 • 105 citations

Metabolic and structural evidence for the existence of a third species of polyphosphoinositide in cells: <scp>d</scp>-phosphatidyl-myo-inositol 3-phosphate

1989 • 104 citations

Activation of a low specific activity form of DNA polymerase α by inositol-1,4-bisphosphate

1988 • 103 citations

V1-type vasopressin receptors in rat brain septum: binding characteristics and effects on inositol phospholipid metabolism

1988 • 102 citations

Purification and characterization of two types of soluble inositol phosphate 5-phosphomonoesterases from rat brain.

1987 • 102 citations

Tachykinin Receptors of the NK1 Type (Substance P) Coupled Positively to Phospholipase C on Cortical Astrocytes from the Newborn Mouse in Primary Culture

1989 • 100 citations

Stereoselectivity and mode of inhibition of phosphoinositide-coupled excitatory amino acid receptors by 2-amino-3-phosphonopropionic acid.

1990 • 100 citations

The properties and subcellular distribution of phosphatidylinositol kinase in mammalian tissues

1969 • 99 citations

Regulation of inositol trisphosphate accumulation by muscarinic cholinergic and H1-histamine receptors on human astrocytoma cells. Differential induction of desensitization by agonists

1987 • 98 citations

Prostaglandin E receptors in bovine adrenal medulla are coupled to adenylate cyclase via Gi and to phosphoinositide metabolism in a pertussis toxin-insensitive manner

1989 • 97 citations

Inositolphospholipid-linked glutamate receptors mediate cerebellar parallel-fiber-Purkinje-cell synaptic transmission.

1989 • 95 citations

Heterologous Expression of Excitability Proteins: Route to More Specific Drugs?

1988 • 95 citations

A phosphoinositide-linked peptide response in astrocytes: Evidence for regional heterogeneity

1988 • 94 citations

Guanine nucleotide and NaF stimulation of phospholipase C activity in rat cerebral-cortical membranes. Studies on substrate specificity

1987 • 94 citations

Selective activation of phosphoinositide hydrolysis by a rigid analogue of glutamate

1990 • 92 citations

Comparison of extracellular ATP and UTP signalling in rat renal mesangial cells. No indications for the involvement of separate purino- and pyrimidino-ceptors

1990 • 90 citations

Lesions of putative glutamatergic pathways potentiate the increase of inositol phospholipid hydrolysis elicited by excitatory amino acids

1987 • 90 citations

Properties of inositol polyphosphate 1-phosphatase.

1988 • 89 citations

Cloning and expression in Escherichia coli of a rat brain cDNA encoding a Ca2+/calmodulin-sensitive inositol 1,4,5-trisphosphate 3-kinase

1990 • 88 citations

Rat brain inositol 1,4,5-trisphosphate 3-kinase. Ca2+-sensitivity, purification and antibody production

1990 • 87 citations

Stereospecific recognition sites for [3H]inositol(1,4,5)-trisphosphate in particulate preparations of rat cerebellum

1987 • 87 citations

Pertussis toxin inhibits signal transduction at a specific metabolotropic glutamate receptor in primary cultures of cerebellar granule cells

1988 • 85 citations

The dephosphorylation of inositol 1,4-bisphosphate to inositol in liver and brain involves two distinct Li+-sensitive enzymes and proceeds via inositol 4-phosphate

1988 • 82 citations

A Putative M₃ Muscarinic Cholinergic Receptor of High Molecular Weight Couples to Phosphoinositide Hydrolysis in Human SK‐N‐SH Neuroblastoma Cells

1988 • 78 citations

Postnatal changes in glutamate stimulated phosphoinositide turnover in rat neocortical synaptoneurosomes

1989 • 77 citations

Modulation of Neuronal Signal Transduction Systems by Extracellular ATP

1988 • 77 citations

Two forms of phosphatidylinositol-specific phospholipase C from bovine brain

1986 • 77 citations

Stimulation of Inositol Phospholipid Hydrolysis by Excitatory Amino Acids Is Enhanced in Brain Slices from Vulnerable Regions after Transient Global Ischemia

1989 • 77 citations

Immunohistochemical Staining and Enzyme Activity Measurements Show myo‐Inositol‐1‐Phosphate Synthase to Be Localized in the Vasculature of Brain

1987 • 77 citations

Regulation of D-myo-inositol 1,4,5-trisphosphate 3-kinase by cAMP-dependent protein kinase and protein kinase C.

1990 • 74 citations

Muscarinic acetylcholine receptor-mediated phosphoinositide turnover in cultured cerebellar granule cells: desensitization by receptor agonists.

1987 • 73 citations

Thromboxane A2 activates phospholipase C in astrocytoma cells via pertussis toxin-insensitive G-protein

1989 • 71 citations

Relationship between agonist-induced muscarinic receptor loss and desensitization of stimulated phosphoinositide turnover in two neuroblastomas: methodological considerations.

1990 • 69 citations

Perinatal Hypoxic‐Ischemic Brain Injury Enhances Quisqualic Acid‐Stimulated Phosphoinositide Turnover

1988 • 69 citations

Stimulation by ATP of Inositol Trisphosphate Accumulation and Calcium Mobilization in Cultured Adrenal Chromaffin Cells

1989 • 67 citations

Mammalian phosphoinositide-specific phospholipase C isoenzymes

1989 • 67 citations

Purification of D-myo-inositol 1,4,5-trisphosphate 3-kinase from rat brain.

1988 • 67 citations

Phospholipase C I and II brain isozymes: immunohistochemical localization in neuronal systems in rat brain.

1988 • 66 citations

Inositol polyphosphates and intracellular calcium release

1989 • 66 citations

Comparison of P2 purinergic receptors of aortic endothelial cells with those of adrenal medulla: evidence for heterogeneity of receptor subtype and of inositol phosphate response.

1990 • 64 citations

Hormone and growth factor receptor-mediated regulation of phospholipase C activity

1989 • 64 citations

Characterization of D-myo-inositol 1,4,5-trisphosphate phosphatase in rat brain

1986 • 61 citations

Purification and properties of D-myo-inositol 1,4,5-trisphosphate 3-kinase from rat brain. Susceptibility to calpain.

1990 • 61 citations

Characteristics of Phorbol Ester‐ and Agonist‐Induced Down‐Regulation of Astrocyte Receptors Coupled to Inositol Phospholipid Metabolism

1988 • 60 citations

Purification of phosphatidylinositol kinase from bovine brain myelin

1987 • 59 citations

Catalytic properties of a purified phosphatidylinositol-4-phosphate kinase from rat brain

1986 • 59 citations

?1B- but not ?1A-adrenoceptors mediate inositol phosphate generation

1990 • 59 citations

Regulation of Brain Phosphatidylinositol-4-phosphate Kinase by GTP Analogues

1989 • 59 citations

The Intact Human Neuroblastoma Cell (SH‐SY5Y) Exhibits High‐Affinity [³H]Pirenzepine Binding Associated with Hydrolysis of Phosphatidylinositols

1988 • 58 citations

Stimulation of Phosphoinositide Hydrolysis by Serotonin in C6 Glioma Cells

1987 • 57 citations

On the involvement of multiple muscarinic receptor subtypes in the activation of phosphoinositide metabolism in rat cerebral cortex.

1990 • 56 citations

A monoclonal antibody distinguishes two types of phosphatidylinositol 4-kinase

1991 • 56 citations

Differences in the adenosine receptors modulating inositol phosphates and cyclic AMP accumulation in mammalian cerebral cortex

1989 • 56 citations

Chronically Administered Lithium Alters Neither myo‐Inositol Monophosphatase Activity nor Phosphoinositide Levels in Rat Brain

1989 • 55 citations

Carbachol and histamine stimulation of guanine-nucleotide-dependent phosphoinositide hydrolysis in rat brain cortical membranes

1989 • 54 citations

Adenosine Inhibition of Histamine‐Stimulated Inositol Phospholipid Hydrolysis in Mouse Cerebral Cortex

1988 • 54 citations

5-HT1A receptor agonists inhibit carbachol-induced stimulation of phosphoinositide turnover in the rat hippocampus

1988 • 52 citations

Comparative studies of phosphoinositide hydrolysis induced by endothelin-related peptides in cultured cerebellar astrocytes, C6-glioma and cerebellar granule cells

1990 • 52 citations

Are there subtypes of the inositol 1,4,5-trisphosphate receptor?

1990 • 52 citations

Ca2+/Calmodulin-sensitive inositol 1,4,5-trisphosphate 3-kinase in rat and bovine brain tissues

1988 • 51 citations

Purification and partial characterization of the phosphatidylinositol 4-phosphate kinase from rat brain

1984 • 51 citations

Chronic lithium treatment reduces norepinephrine-stimulated inositol phospholipid hydrolysis in rat cortex

1987 • 50 citations

Inositol 1,3,4,6-tetrakisphosphate mobilizes calcium in Xenopus oocytes with high potency

1991 • 50 citations

Purification and characterization of membrane-bound phosphatidylinositol kinase from rat brain.

1988 • 49 citations

Modulation of Phosphoinositide Hydrolysis by NaF and Aluminum in Rat Cortical Slices

1988 • 47 citations

Mastoparan inhibits phosphoinositide hydrolysis via pertussis toxin‐intensive G‐protein in human astrocytoma cells

1990 • 46 citations

Maitotoxin, a potent, general activator of phosphoinositide breakdown

1989 • 46 citations

Serotonergic, adrenergic and histaminergic receptors coupled to phospholipase C in cultured cerebellar granule cells of rats

1987 • 45 citations

Cyclic AMP inhibits inositol polyphosphate production and calcium mobilization in neuroblastoma X glioma NG108-15 cells.

1990 • 45 citations

The Discovery of a 3-Phosphomonoesterase That Hydrolyzes Phosphatidylinositol 3-Phosphate in NIH 3T3 Cells

1989 • 45 citations

Dopamine Receptor Stimulation Does Not Affect Phosphoinositide Hydrolysis in Slices of Rat Striatum

1988 • 44 citations

Purification and properties of inositol-1,4-bisphosphatase from bovine brain

1988 • 44 citations

Myo-inositol(1,4,5)trisphosphorothioate binds to specific [3H]inositol(1,4,5)trisphosphate sites in rat cerebellum and is resistant to 5-phosphatase

1988 • 44 citations

A M3 muscarinic receptor coupled to inositol phosphate formation in the rat cochlea?

1990 • 44 citations

Identification of glycosylphosphatidylinositol-specific phospholipases C in mouse brain membranes

1990 • 43 citations

Pharmacological characterization of serotonin-stimulated phosphoinositide turnover in brain regions of the immature rat.

1988 • 43 citations

Neurotransmitter and Depolarization‐Stimulated Accumulation of Inositol 1,3,4,5‐Tetrakisphosphate Mass in Rat Cerebral Cortex Slices

1990 • 42 citations

The identification of a novel inositol lipid, phosphatidylinostiol trisphosphate (PIP3), in rat cerebrum using in vivo techniques

1989 • 42 citations

Kappa opioid receptors stimulate phosphoinositide turnover in rat brain

1990 • 42 citations

Desensitization of Muscarinic Receptor‐Coupled Phosphoinositide Hydrolysis in Rat Hippocampus: Comparisons with the α₁‐Adrenergic Response

1988 • 41 citations

Lasting increase in excitatory amino acid receptor-mediated polyphosphoinositide hydrolysis in the amygdala/pyriform cortex of amygdala-kindled rats

1989 • 41 citations

Endothelin-1 induces intracellular calcium rise and inositol 1,4,5-trisphosphate formation in cultured rat and human glioma cells

1990 • 40 citations

Pertussis toxin inhibits norepinephrine-stimulated inositol phosphate formation in primary brain cell cultures.

1990 • 39 citations

Extracellular adenosine triphosphate activates phospholipase C and mobilizes intracellular calcium in primary cultures of sheep anterior pituitary cells

1989 • 38 citations

Rapid purification of inositol monophosphate phosphatase from beef brain

1988 • 37 citations

Characteristics of endothelin-1 and endothelin-3 stimulation of phosphoinositide breakdown differ between regions of guinea-pig and rat brain

1990 • 37 citations

Developmental changes in the chemosensitivity of rat brain synaptoneurosomes to excitatory amino acids, estimated by inositol phosphate formation

1989 • 37 citations

Inositol 1,4,5-Trisphosphate 3-Kinase mRNA: High Levels in the Rat Hippocampal CA1 Pyramidal and Dentate Gyrus Granule Cells and in Cerebellar Purkinje Cells

1991 • 37 citations

Histamine H1-receptors mediate phosphoinositide hydrolysis in astrocyte-enriched primary cultures

1988 • 36 citations

Inhibition of Muscarinic‐Coupled Phosphoinositide Hydrolysis by N‐Methyl‐<scp>d</scp>‐Aspartate Is Dependent on Depolarization via Channel Activation

1990 • 36 citations

Stimulatory and inhibitory actions of excitatory amino acids on inositol phospholipid metabolism in rabbit retina. Evidence for a specific quisqualate receptor subtype associated with neurones

1990 • 36 citations

Degradation of inositol 1,3,4,5-tetrakisphosphates by porcine brain cytosol yields inositol 1,3,4-trisphosphate and inositol 1,4,5-trisphosphate

1988 • 36 citations

Antagonism of 5-hydroxytryptamine2 receptor-mediated phosphatidylinositol turnover by d-lysergic acid diethylamide.

1988 • 36 citations

Characterization of Bradykinin‐Induced Phosphoinositide Turnover in Neurohybrid NCB‐20 Cells

1988 • 36 citations

Immunohistochemical localization of a brain isozyme of phospholipase C (PLC III) in astroglia in rat brain

1989 • 35 citations

Purification and characterization of PLC-βm, a muscarinic cholinergic regulated phospholipase C from rabbit brain membrane

1990 • 34 citations

Inhibition of inositol phospholipid synthesis and norepinephrine-stimulated hydrolysis in rat brain slices by excitatory amino acids

1989 • 34 citations

Guanine nucleotides mediate stimulatory and inhibitory effects on cerebral-cortical membrane phospholipase C activity

1989 • 34 citations

Molecular target sizes of inositol 1,4,5-trisphosphate receptors in liver and cerebellum

1990 • 34 citations

Developmental and Regional Studies of the Metabolism of Inositol 1,4,5‐Trisphosphate in Rat Brain

1990 • 33 citations

Sarafotoxin receptors mediate phosphoinositide hydrolysis in various rat brain regions

1989 • 33 citations

Identification of a novel inositol phosphate recognition site: Specific [3H]inositol hexakisphosphate binding to brain regions and cerebellar membranes

1990 • 33 citations

Muscarinic Receptor‐Stimulated Phosphoinositide Turnover in Human SK‐N‐SH Neuroblastoma Cells: Differential Inhibition by Agents that Elevate Cyclic AMP

1989 • 33 citations

Fluoride inhibits agonist-induced formation of inositol phosphates in rat cortex

1988 • 32 citations

Phospholipase C activity in NCB-20 cells is inhibited by protein kinase A-mediated phosphorylation of low molecular mass GTP-binding proteins.

1990 • 32 citations

High‐affinity inositol 1,3,4,5‐tetrakisphosphate receptor from cerebellum: solubilization, partial purification and characterization

1990 • 32 citations

Muscarinic Cholinergic Receptor‐Mediated Phosphoinositide Metabolism in Peripheral Nerve

1991 • 32 citations

Characterization of the Quisqualate Receptor Linked to Phosphoinositide Hydrolysis in Neurocortical Cultures

1990 • 32 citations

Lithium Stimulation of Membrane‐Bound Phospholipase C from PC 12 Cells Exposed to Nerve Growth Factor

1988 • 31 citations

5‐Hydroxytryptamine‐Stimulated Inositol Phospholipid Hydrolysis in the Mouse Cortex Has Pharmacological Characteristics Compatible with Mediation via 5‐HT₂ Receptors but This Response Does Not Reflect Altered 5‐HT₂ Function After 5,7‐Dihydroxytryptamine Lesioning or Repeated Antidepressant Treatments

1988 • 31 citations

Purification of a Phosphatidylinositol 4‐Phosphate Kinase from Bovine Brain Membranes

1990 • 31 citations

Pharmacological differences between muscarinic receptors coupled to phosphoinositide turnover and those coupled to adenylate cyclase inhibition

1989 • 31 citations

G-protein involvement in central-nervous-system muscarinic-receptor-coupled polyphosphoinositide hydrolysis

1988 • 31 citations

Isolation and functional characterization of an inositol trisphosphate receptor from brain

1989 • 30 citations

An inositol phosphatide containing carbohydrate, isolated from human brain

1961 • 29 citations

Comparison of α₁‐Adrenergic Receptor‐Stimulated Inositol Phosphate Formation in Primary Neuronal and Glial Cultures

1990 • 29 citations

Specific binding sites for inositolhexakisphosphate in brain and anterior pituitary.

1990 • 28 citations

Phosphoinositide hydrolysis in permeabilized SH‐SY5Y human neuroblastoma cells is inhibited by mastoparan

1989 • 28 citations

Differential Regulation of Phosphoinositide Phosphodiesterase Activity in Brain Membranes by Guanine Nucleotides and Calcium

1988 • 28 citations

Substrate properties of analogs of myo-inositol.

1988 • 28 citations

Interactions between cyclic AMP and inositol phosphate transduction systems in astrocytes in primary culture

1990 • 27 citations

A phencyclidine recognition site is associated with N-methyl-D-aspartate inhibition of carbachol-stimulated phosphoinositide hydrolysis in rat cortical slices.

1989 • 27 citations

Thyrotrophin-releasing hormone stimulates polyphosphoinositide metabolism in the frog neurointermediate lobe

1990 • 27 citations

κ-Opioid agonist inhibits phospholipase C, possibly via an inhibition of G-protein activity

1990 • 27 citations

Polyphosphoinositides are the major source of inositol phosphates in carbamoylcholine-stimulated SK-N-SH neuroblastoma cells.

1990 • 27 citations

The human astrocytoma cell line 1321 N1 contains M₂‐glandular type muscarinic receptors linked to phosphoinositide turnover

1989 • 27 citations

Reduction of Muscarinic Receptor Density and of Guanine Nucleotide‐Stimulated Phosphoinositide Hydrolysis in Human SH‐SY5Y Neuroblastoma Cells Following Long‐Term Treatment with 12‐O‐Tetradecanoylphorbol 13‐Acetate or Mezerein

1990 • 27 citations

Hormone research

1978 • 26 citations

A novel role for dopamine: inhibition of muscarinic cholinergic-stimulated phosphoinositide hydrolysis in rat brain cortical membranes

1990 • 26 citations

Excitatory amino acids inhibit stimulated phosphoinositide hydrolysis in the rat prefrontal cortex

1989 • 26 citations

M₁ Muscarinic Acetylcholine Receptor in Cultured Rat Neostriatum Regulates Phosphoinositide Hydrolysis

1990 • 26 citations

Molecular mechanisms of homologous desensitization and internalization of muscarinic receptors in primary cultures of neonatal corticostriatal neurons.

1990 • 26 citations

Activation of phospholipase C in rabbit brain membranes by carbachol in the presence of GTPγS; effects of biological detergents

1990 • 26 citations

Glutamate‐Stimulated, Guanine Nucleotide‐Mediated Phosphoinositide Turnover in Astrocytes Is Inhibited by Cyclic AMP

1990 • 25 citations

Excitatory Amino Acid‐Induced Formation of Inositol Phosphates in Guinea‐Pig Cerebral Cortical Slices: Involvement of Ionotropic or Metabotropic Receptors?

1990 • 23 citations

Substance P and related tachykinins induce receptor-mediated hydrolysis of polyphosphoinositides in the rat anterior pituitary

1990 • 23 citations

Stimulus-responsive and rapid formation of inositol pentakisphosphate in cultured adrenal chromaffin cells.

1990 • 23 citations

Rapid accumulation and sustained turnover of inositol phosphates in cerebral-cortex slices after muscarinic-receptor stimulation

1989 • 23 citations

Nerve Growth Factor Potentiates the Hormone‐Stimulated Intracellular Accumulation of Inositol Phosphates and Ca²⁺ in Rat PC12 Pheochromocytoma Cells: Comparison with the Effect of Epidermal Growth Factor

1989 • 23 citations

Effects of opioid compounds on basal and muscarinic induced accumulation of inositol phosphates in cultured bovine chromaffin cells

1988 • 21 citations

Further characterisation of excitatory amino acid receptors coupled to phosphoinositide metabolism in astrocytes

1990 • 21 citations

Muscarinic-stimulated Norepinephrine Release and Phosphoinositide Hydrolysis in PC 12 Cells Are Independent Events

1989 • 21 citations

Modulation of phosphoinositide metabolism in rat brain slices by excitatory amino acids, arachidonic acid, and GABA

1990 • 21 citations

Bradykinin-induced accumulation of [3H]inositol-1-phosphate in human embryonic pituitary tumour cells by activation of a B2-receptor

1988 • 21 citations

Histamine-induced intracellular free Ca++, inositol phosphates and electrical changes in murine N1E-115 neuroblastoma cells.

1988 • 21 citations

Serotonin-2 receptors coupled to phosphoinositide hydrolysis in a clonal cell line.

1990 • 21 citations

Evidence that Phosphoinositide Metabolism in Rat Cerebral Cortex Stimulated by Pilocarpine, Physostigmine, and Pargyline In Vivo Is Not Changed by Chronic Lithium Treatment

1990 • 20 citations

Bradykinin stimulates phosphoinositide metabolism and prolactin secretion in rat anterior pituitary cells

1989 • 20 citations

Differences between muscarinic-receptor- and Ca2+-induced inositol polyphosphate isomer accumulation in rat cerebral-cortex slices

1990 • 20 citations

Effect of angiotensin II and III on inositol polyphosphate production in differentiated NG108-15 hybrid cells

1990 • 20 citations

Type-A cholecystokinin receptors in CHP212 neuroblastoma cells: evidence for association with G protein and activation of phosphoinositide hydrolysis.

1989 • 20 citations

Changes in inositol lipids and phosphates after stimulation of the MAS-transfected NG115-401L-C3 cell line by mitogenic and non-mitogenic stimuli

1990 • 20 citations

Heterologous desensitization of bradykinin-induced phosphatidylinositol response and Ca2+ mobilization by neurotensin in NG108-15 cells

1989 • 19 citations

Further evidence against the coupling of dopamine receptors to phosphoinositide hydrolysis in rat striatum

1990 • 19 citations

Preferential coupling of cell surface muscarinic receptors to phosphoinositide hydrolysis in human neuroblastoma cells.

1991 • 19 citations

[3H]propylbenzilylcholine mustard-labeling of muscarinic cholinergic receptors that selectively couple to phospholipase C or adenylate cyclase in two cultured cell lines.

1987 • 19 citations

Muscarinic receptors and second-messenger responses of neurons in primary culture

1990 • 19 citations

Vasopressin stimulates inositol phospholipid metabolism in rat medulla oblangata in vivo

1988 • 19 citations

Hydrolysis of polyphosphoinositides in astrocytes by platelet-activating factor

1990 • 19 citations

Properties of a soluble inositol 1,3,4,5-tetrakisphosphate 3-phosphatase from porcine brain

1990 • 17 citations

Glycine Potentiates the Stimulation of Inositol Phospholipid Hydrolysis by Excitatory Amino Acids in Primary Cultures of Cerebellar Neurons

1989 • 17 citations

Muscarinic receptor-mediated phosphoinositide hydrolysis in the rat retina.

1988 • 17 citations

Inositol phospholipid hydrolysis in human brain; adenosine inhibition of the response to histamine

1990 • 17 citations

Vasoactive intestinal polypeptide (VIP) potentiates the muscarinic stimulation of phosphoinositide turnover in rat cerebral cortex

1987 • 17 citations

Muscarinic Receptor Stimulation Increases Inositol‐Phospholipid Metabolism and Inhibits Cyclic AMP Accumulation in PC 12 Cells

1989 • 16 citations

Differential regulation of cholecystokinin- and muscarinic-receptor-mediated phosphoinositide turnover in Flow 9000 cells

1988 • 15 citations

In Vivo Determination of 5‐Hydroxytryptamine Receptor‐Stimulated Phosphoinositide Turnover in Rat Brain

1989 • 15 citations

Effects of neurotransmitters and peptides on phospholipid hydrolysis in sympathetic and sensory neurons

1990 • 15 citations

Stimulation of phosphoinositide degradation and phosphatidylinositol-4-phosphate phosphorylation by GTP exclusively in plasma membrane of rat brain

1989 • 15 citations

Evidence for at least four different inositol bisphosphatases in bovine brain

1989 • 14 citations

Gonadotropin-Releasing Hormone-Stimulated Phosphoinositide Hydrolysis in the Anterior Pituitary

1988 • 14 citations

Stimulation of Inositol Incorporation into Lipids of PC 12 Cells by Nerve Growth Factor and Bradykinin

1988 • 14 citations

Identification of Multiple Phosphoinositide‐Linked Receptors on Human SK‐N‐MC Neuroepithelioma Cells

1991 • 13 citations

Thyrotropin-releasing hormone receptor occupancy determines the fraction of the responsive pool of inositol lipids hydrolysed in rat pituitary tumour cells

1990 • 13 citations

Potentiation by γ‐Aminobutyric Acid of α₁‐Agonist‐Induced Accumulation of Inositol Phosphates in Slices of Rat Cerebral Cortex

1990 • 13 citations

Inositol hexakisphosphate stimulus 45Ca2+ uptake in anterior pituitary cells in culture

1990 • 12 citations

Guanosine 5′‐O‐Thiotriphosphate and Sodium Fluoride Activate Polyphosphoinositide Hydrolysis in Rat Cortical Membranes by Distinct Mechanisms

1990 • 12 citations

Phosphatidylinositol-anchored glycoproteins of PC12 pheochromocytoma cells and brain

1988 • 11 citations

GABA pretreatment enhances glutamate mediated phosphoinositide hydrolysis in neurons

1988 • 10 citations

Ca2+-dependence provides evidence for differing mechanisms of GABA-induced inositol phosphate formation and GABA potentiation of inositol phosphate formation induced by noradrenaline in rat cerebral cortex

1990 • 10 citations

Platelet Activating Factor Induces Inositol Phosphate Accumulation in Cultures of Rat and Bovine Anterior Pituitary Cells*

1990 • 10 citations

First pharmacological characterization of TRH receptors linked to phosphoinositide hydrolysis in GH3 pituitary cells using agonist specificity of eight TRH analogs

1989 • 10 citations

Gastrin-releasing peptide receptor in rat brain membranes: specific binding and stimulation of phosphoinositide breakdown.

1989 • 10 citations

Bombesin-like peptides stimulate phosphatidylinositol turnover in rat brain slices

1988 • 9 citations

Altered Nerve Myo-Inositol Metabolism in Experimental Diabetes and Its Relationship to Nerve Function

1985 • 9 citations

Effects of bradykinin, GTPγS, R59022 and N-ethylmaleimide on inositol phosphate production in NG108-15 cells

1989 • 9 citations

The effects of thyrotropin-releasing hormone and potassium depolarization on phosphoinositide metabolism and cytoplasmic calcium in bovine pituitary cells

1989 • 9 citations

Phosphoinositides and Their Stimulated Breakdown

1991 • 8 citations

Effects of dopamine on phosphoinositide hydrolysis in slices of rat striatum and cortex

1990 • 8 citations

The effect of substance P and other tachykinins on inositol phospholipid hydrolysis in rabbit retina, superior colliculus and retinal cultures

1989 • 8 citations

Profile of phosphatidylinositol metabolism stimulated by carbachol and glutamate in primary cultures of rat cerebellar neurons

1989 • 8 citations

Inositol hexakisphosphate biosynthesis in mammalian brain: identification of a novel inositol pentakisphosphate kinase

1990 • 5 citations

Investigation of inositol hexakisphosphate actions in rat nucleus tractus solitarius in vitro

1989 • 4 citations

ChemInform Abstract: Phosphoinositides and Their Stimulated Breakdown

1991 • 3 citations