Altered Nerve Myo-Inositol Metabolism in Experimental Diabetes and Its Relationship to Nerve Function

Effects of insulin and dietary myoinositol on impaired peripheral motor nerve conduction velocity in acute streptozotocin diabetes.

1975 • 471 citations

A voltage‐clamp analysis of inward (anomalous) rectification in mouse spinal sensory ganglion neurones.

1983 • 444 citations

Hyperglycemia, Polyol Metabolism, and Complications of Diabetes Mellitus

1975 • 326 citations

Aldose Reductase Inhibition Improves Nerve Conduction Velocity in Diabetic Patients

1983 • 314 citations

Scanning Electron Microscopy

1981 • 287 citations

Peripheral nerve structure and function in experimental diabetes

1974 • 266 citations

Impaired rat sciatic nerve sodium-potassium adenosine triphosphatase in acute streptozocin diabetes and its correction by dietary myo-inositol supplementation.

1983 • 246 citations

Diabetic Neuropathy—New Concepts of Its Etiology

1979 • 218 citations

Molecular considerations relevant to the mechanism of active transport

1981 • 210 citations

Nerve Conduction Changes in Experimental Diabetes*

1964 • 195 citations

Polyol Pathway Activity and Myo-Inositol Metabolism: A Suggested Relationship in the Pathogenesis of Diabetic Neuropathy

1983 • 183 citations

Action of Sorbinil in Diabetic Peripheral Nerve: Relationship of Polyol (Sorbitol) Pathway Inhibition to a myo-Inositol-mediated Defect in Sodium-Potassium ATPase Activity

1984 • 178 citations

Diabetic nephropathy and arterial hypertension

1983 • 178 citations

Variations in motor conduction velocity produced by acute changes of the metabolic state in diabetic patients

1968 • 168 citations

POLYOL ACCUMULATIONS IN NERVOUS TISSUE OF RATS WITH EXPERIMENTAL DIABETES AND GALACTOSAEMIA *

1967 • 166 citations

The Effect of Aldose Reductase Inhibition on Motor Nerve Conduction Velocity in Diabetic Rats

1982 • 154 citations

Osmotic changes in experimental galactose cataracts

1962 • 150 citations

Free and lipid myo-inositol in tissues from rats with acute and less severe streptozotocin-induced diabetes

1977 • 147 citations

Sodium- and energy-dependent uptake of myo-inositol by rabbit peripheral nerve. Competitive inhibition by glucose and lack of an insulin effect.

1982 • 146 citations

Peripheral nerves in early experimental diabetes

1978 • 143 citations

Changes in nodal function in nerve fibres of the spontaneously diabetic BB‐Wistar rat: Potential clamp analysis

1981 • 143 citations

Diminished ouabain-sensitive, sodium-potassium ATPase activity in sciatic nerves of rats with streptozotocin-induced diabetes

1976 • 135 citations

Early and preventable changes of peripheral nerve structure and function in insulin-deficient diabetic rats.

1979 • 127 citations

The oxygen consumption of mammalian non‐myelinated nerve fibres at rest and during activity

1967 • 117 citations

Free and lipid inositol, sorbitol and sugars in sciatic nerve obtained post-mortem from diabetic patients and control subjects

1983 • 110 citations

Phosphatidylinositol as the endogenous activator of the (Na+ + K+)-ATPase in microsomes of rabbit kidney

1978 • 98 citations

Effects of Acute Experimental Diabetes on Composite Energy Metabolism in Peripheral Nerve Axons and Schwann Cells

1981 • 95 citations

Distal neuropathy in experimental diabetes mellitus

1980 • 91 citations

Polyol pathway activity and myo-inositol metabolism. A suggested relationship in the pathogenesis of diabetic neuropathy

1983 • 89 citations

Effects of aldose reductase inhibitor treatment in diabetic polyneuropathy - a clinical and neurophysiological study.

1981 • 88 citations

Diabetic Polyneuropathy: The Importance of Insulin Deficiency, Hyperglycemia and Alterations in Myoinositol Metabolism in Its Pathogenesis

1976 • 88 citations

In Vitro Studies of the Substrates for Energy Production and the Effects of Insulin on Glucose Utilization in the Neural Components of Peripheral Nerve

1979 • 87 citations

Significance of Tissue myo -Inositol Concentrations in Metabolic Regulation in Nerve

1982 • 87 citations

The (non) specificity in the lipid-requirement of calcium- and (sodium plus potassium)-transporting adenosine triphosphatases

1981 • 83 citations

Selective Effects of Myo-inositol Administration on Sciatic and Tibial Motor Nerve Conduction Parameters in the Streptozocin-Diabetic Rat

1982 • 81 citations

The effect of aldose reductase inhibition on motor nerve conduction velocity in diabetic rats

1982 • 81 citations

Peripheral neuropathy in the spontaneously diabetic BB-Wistar-rat

1980 • 80 citations

Metabolic abnormalities in diabetic peripheral nerve: Relation to impaired function

1983 • 75 citations

Sorbitol, inositol and nerve conduction in diabetes

1983 • 68 citations

Action of sorbinil in diabetic peripheral nerve. Relationship of polyol (sorbitol) pathway inhibition to a myo-inositol-mediated defect in sodium-potassium ATPase activity

1984 • 65 citations

Abnormal Sciatic Nerve Myo-inositol Metabolism in the Streptozotocin-diabetic Rat: Effect of Insulin Treatment

1980 • 63 citations

Regulation of rat brain (Na+ + K+)-ATPase activity by cyclic AMP

1982 • 56 citations

Alterations of Inositol Lipid Metabolism of Rat Sciatic Nerve in Streptozotocin‐Induced Diabetes

1981 • 50 citations

RABBIT SCIATIC NERVE FASCICLE AND‘ENDONEURIAL’PREPARATIONS FOR IN VITRO STUDIES OF PERIPHERAL NERVE GLUCOSE METABOLISM

1979 • 50 citations

The accumulation of dulcitol and water in rabbit lens incubated with galactose

1962 • 49 citations

In Vivo Functioning of the Na+, K+-Activated ATPase

1981 • 49 citations

Changes in myo-inositol permeability in the lens due to cataractous conditions

1968 • 43 citations

Effect of experimental diabetes and insulin on phosphatidylinositol synthesis in rat sciatic nerve

1979 • 42 citations

Lipid synthesis in peripheral nerve from alloxan diabetic rats

1966 • 37 citations

INSULIN RESPONSE OF PERIPHERAL NERVE

1964 • 36 citations

Comparison of clinical couse and sequential electrophysiological tests in diabetics with symptomatic polyneuropathy and its implications for clinical trials

1981 • 34 citations

Insulin response of peripheral nerve

1965 • 32 citations

Properties of isolated nerve fibres from alloxanized rats.

1969 • 32 citations

Selective effects of myo-inositol administration on sciatic and tibial motor nerve conduction parameters in the streptozocin-diabetic rat

1982 • 24 citations

In vitro studies of the substrates for energy production and the effects of insulin on glucose utilization in the neural components of peripheral nerve

1979 • 23 citations