Stimulation of Phosphoinositide Hydrolysis by Serotonin in C6 Glioma Cells

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES

1957 • 63,238 citations

Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands

1982 • 2,148 citations

Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

1983 • 1,937 citations

Differentiated Rat Glial Cell Strain in Tissue Culture

1968 • 1,480 citations

Multiple serotonin receptors: differential binding of [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol.

1979 • 1,321 citations

The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain.

1980 • 1,099 citations

[3H]Ketanserin (R 41 468), a selective 3H-ligand for serotonin2 receptor binding sites. Binding properties, brain distribution, and functional role.

1982 • 1,049 citations

8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site

1983 • 869 citations

Receptor binding profile of R 41 468, A novel antagonist at 5-HT2 receptors

1981 • 848 citations

Long-Term Antidepressant Treatment Decreases Spiroperidol-Labeled Serotonin Receptor Binding

1980 • 840 citations

RECEPTORS AND PHOSPHOINOSITIDE-GENERATED SECOND MESSENGERS

1985 • 722 citations

Discrimination of Multiple [³H]5‐Hydroxytryptamine Binding Sites by the Neuroleptic Spiperone in Rat Brain

1981 • 629 citations

Molecular pharmacology of 5-HT1 and 5-HT2 recognition sites in rat and pig brain membranes: Radioligand binding studies with [3H]5-HT, [3H]8-OH-DPAT, (−)[125I]iodocyanopindolol, [3H]mesulergine and [3H]Ketanserin

1985 • 581 citations

Modification of the lowry procedure for the analysis of proteolipid protein

1972 • 563 citations

Inositol Phospholipid Hydrolysis in Rat Cerebral Cortical Slices: I. Receptor Characterisation

1984 • 517 citations

Determination of selective and nonselective compounds for the 5-HT 1A and 5-HT 1B receptor subtypes in rat frontal cortex.

1984 • 324 citations

Stepwise enzymatic dephosphorylation of inositol 1,4,5-trisphosphate to inositol in liver

1984 • 321 citations

PHOSPHATIDYLINOSITOL TURNOVER IN RECEPTOR MECHANISM AND SIGNAL TRANSDUCTION

1985 • 207 citations

Evidence that phospholipid turnover is the signal transducing system coupled to serotonin-S2 receptor sites.

1985 • 206 citations

5-Hydroxytryptamine-stimulated inositol phospholipid hydrolysis in rat cerebral cortex slices: pharmacological characterization and effects of antidepressants.

1985 • 198 citations

Serotonin-stimulated phosphoinositide turnover: mediation by the S2 binding site in rat cerebral cortex but not in subcortical regions.

1985 • 197 citations

Efficient fluorography of 3H and 14C on thin layers

1978 • 190 citations

Selective 5ht-2 antagonists inhibit serotonin stimulated phosphatidylinositol metabolism in cerebral cortex

1984 • 179 citations

Two distinct serotonin receptors: regional variations in receptor binding in mammalian brain

1981 • 176 citations

"Transdifferentiation" of C6 Glial Cells in Culture

1980 • 175 citations

Aortic recognition sites for serotonin (5HT) are coupled to phospholipase C and modulate phosphatidylinositol turnover

1984 • 146 citations

Activation of Muscarinic and of α₁‐Adrenergic Receptors on Astrocytes Results in the Accumulation of Inositol Phosphates

1985 • 136 citations

Histamine Stimulation of Inositol 1‐Phosphate Accumulation in Lithium‐Treated Slices from Regions of Guinea Pig Brain

1984 • 116 citations

SEPARATE 5‐HYDROXYTRYPTAMINE RECEPTORS ON THE SALIVARY GLAND OF THE BLOWFLY ARE LINKED TO THE GENERATION OF EITHER CYCLIC ADENOSINE 3‘,5’‐MONOPHOSPHATE OR CALCIUM SIGNALS

1981 • 111 citations

Regional distribution of polyphosphoinositides in rat brain

1971 • 110 citations

Receptors and phosphoinositide metabolism in the central nervous system

1986 • 104 citations

Cholinergic‐ and Adrenergic‐Stimulated Inositide Hydrolysis in Brain: Interaction, Regional Distribution, and Coupling Mechanisms

1985 • 99 citations

Characterization of alpha-1 adrenergic receptors linked to [3H]inositol metabolism in rat cerebral cortex.

1984 • 99 citations

Inositol phosphates: Profusion and confusion

1986 • 93 citations

Serotonin‐Elicited Amplification of Adenylate Cyclase Activity in Hippocampal Membranes from Adult Rat

1983 • 89 citations

GLIAL CELL LINES

1977 • 88 citations

Characterization of neurotransmitter receptor-mediated phosphatidylinositol hydrolysis in the rat hippocampus

1984 • 86 citations

Astrocytes: Normal, Reactive and Neoplastic

1984 • 85 citations

Solubilization of the enzyme catalyzing CDP-diglyceride-independent incorporation of myo-inositol into phosphatidyl inositol and its comparison to CDP-diglyceride:Inositol transferase

1977 • 66 citations

2-[125Iodo]LSD, a new ligand for the characterisation and localisation of 5-HT2 receptors

1984 • 65 citations

Receptor-stimulated inositol phospholipid metabolism in the central nervous system

1982 • 56 citations

Characteristics of an amiloride‐sensitive sodium entry pathway in cultured rodent glial and neuroblastoma cells

1983 • 50 citations

Central Serotonin Receptors

1984 • 49 citations

Uptake of biogenic amines by glial cells in culture I. A neuronal-like transport system for serotonin

1978 • 41 citations

Manganese Stimulates the Incorporation of [³H]Inositol into a Pool of Phosphatidylinositol in Brain That Is Not Coupled to Agonist‐Induced Hydrolysis

1985 • 37 citations

Alterations of Phospholipid Metabolism in Rat Cerebral Cortex Mince Induced by Cationic Amphiphilic Drugs

1981 • 32 citations

Intracellular Ca2+ elevation induced by a neurotransmitter in a glial cell clone

1984 • 32 citations

Phosphatidyl inositol: myo-Inositol exchange enzyme from rat liver: Partial purification and characterization

1980 • 32 citations

Serotonin-receptor coupled with membrane electrogenesis in a rat glioma clone

1984 • 30 citations

Serotonergic agonists stimulate inositol lipid metabolism in rabbit platelets

1985 • 26 citations

Detection of Receptor-Linked Phosphoinositide Metabolism in Brain of Lithium-Treated Rats

1985 • 25 citations