Cloning and expression in Escherichia coli of a rat brain cDNA encoding a Ca2+/calmodulin-sensitive inositol 1,4,5-trisphosphate 3-kinase

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

A simplification of the protein assay method of Lowry et al. which is more generally applicable

1977 • 8,485 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

The scanning model for translation: an update.

1989 • 3,525 citations

Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange.

1977 • 2,408 citations

Efficient isolation of genes by using antibody probes.

1983 • 2,065 citations

How calmodulin binds its targets: sequence independent recognition of amphiphilic α-helices

1990 • 839 citations

The inositol tris/tetrakisphosphate pathway—demonstration of Ins(l,4,5)P3 3-kinase activity in animal tissues

1986 • 702 citations

Synergism of inositol trisphosphate and tetrakisphosphate in activating Ca2+-dependent K+ channels

1987 • 529 citations

Substrate specificity of protein kinase C

1986 • 521 citations

Protein kinases. Regulation by autoinhibitory domains.

1990 • 322 citations

Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution.

1989 • 231 citations

Regulation of free calmodulin levels by neuromodulin: neuron growth and regeneration

1990 • 226 citations

Activation of calcineurin by limited proteolysis.

1983 • 178 citations

[7] λgt 11: Gene isolation with antibody probes and other applications

1987 • 155 citations

Molecular Cloning and Expression of a Complementary DNA for Inositol 1,4,5-Trisphosphate 3-Kinase

1990 • 142 citations

Cloning and expression of bovine brain inositol monophosphatase.

1990 • 107 citations

Rat brain inositol 1,4,5-trisphosphate 3-kinase. Ca2+-sensitivity, purification and antibody production

1990 • 87 citations

Catalytic properties of inositol trisphosphate kinase: activation by Ca ²⁺ and calmodulin

1987 • 84 citations

Calcium-calmodulin stimulates inositol 1,4,5-trisphosphate kinase activity from insulin-secreting RINm5F cells.

1987 • 83 citations

Human 27‐kDa calbindin complementary DNA sequence

1987 • 82 citations

Fibroblasts Transformed with v- src Show Enhanced Formation of an Inositol Tetrakisphosphate

1989 • 67 citations

Turkey erythrocytes possess a membrane-associated inositol 1,4,5-trisphosphate 3-kinase that is activated by Ca2+ in the presence of calmodulin

1987 • 62 citations

Purification of bovine brain inositol 1,4,5-trisphosphate 3-kinase. Identification of the enzyme by sodium dodecyl sulphate/polyacrylamide-gel electrophoresis

1989 • 62 citations

Ca2+/Calmodulin-sensitive inositol 1,4,5-trisphosphate 3-kinase in rat and bovine brain tissues

1988 • 51 citations

Purification and characterization of inositol 1,4,5-trisphosphate 3-kinase from pig aortic smooth muscle

1988 • 48 citations

Reversible and irreversible activation of cyclic nucleotide phosphodiesterase: separation of the regulatory and catalytic domains by limited proteolysis.

1984 • 23 citations