Intracellular Ca2+ activates phospholipase C

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

Inositol phospholipids and cell surface receptor function

1975 • 2,458 citations

INTRACELLULAR CALCIUM HOMEOSTASIS

1987 • 2,183 citations

Turnover of Inositol Phospholipids and Signal Transduction

1984 • 1,629 citations

Glutamate stimulates inositol phosphate formation in striatal neurones

1985 • 734 citations

Translocation of Protein Kinase C Activity May Mediate Hippocampal Long-Term Potentiation

1986 • 532 citations

Receptor Activation and Inositol Lipid Hydrolysis in Neural Tissues

1987 • 341 citations

Phorbol ester inhibits phosphoinositide hydrolysis and calcium mobilization in cultured astrocytoma cells.

1985 • 274 citations

Guanine nucleotides induce Ca2+-independent insulin secretion from permeabilized RINm5F cells.

1987 • 244 citations

Purification and characterization of two immunologically distinct phosphoinositide-specific phospholipases C from bovine brain.

1987 • 243 citations

Phorbol ester and 1-oleoyl-2-acetylglycerol inhibit angiotensin activation of phospholipase C in cultured vascular smooth muscle cells.

1985 • 240 citations

Hydrolysis of polyphosphoinositides by purified sheep seminal vesicle phospholipase C enzymes.

1984 • 225 citations

Thyrotropin-releasing hormone activates a Ca2+-dependent polyphosphoinositide phosphodiesterase in permeable GH3 cells. GTP gamma S potentiation by a cholera and pertussis toxin-insensitive mechanism.

1986 • 197 citations

Muscarinic Receptors in Chromaffin Cell Cultures Mediate Enhanced Phospholipid Labeling but Not Catecholamine Secretion

1981 • 193 citations

Inositol Phospholipid Hydrolysis in Rat Cerebral Cortical Slices: II. Calcium Requirement

1984 • 182 citations

Calcium-activated hydrolysis of phosphatidyl-myo-inositol 4-phosphate and phosphatidyl-myo-inositol 4,5-bisphosphate in guinea-pig synaptosomes

1978 • 167 citations

Inositol 1,4,5-trisphosphate and guanine nucleotides activate calcium release from endoplasmic reticulum via distinct mechanisms.

1986 • 140 citations

Effects of phorbol esters, diglyceride, and cholinergic agonists on the subcellular distribution of protein kinase C in intact or digitonin-permeabilized adrenal chromaffin cells.

1986 • 134 citations

Cholinergic Stimulation of Inositol Phosphate Formation in Bovine Adrenal Chromaffin Cells: Distinct Nicotinic and Muscarinic Mechanisms

1987 • 132 citations

Dihydropyridine calcium channel activators and antagonists influence depolarization-evoked inositol phospholipid hydrolysis in brain

1985 • 112 citations

Potentiation by thrombin of the secretion of serotonin from permeabilized platelets equilibrated with Ca2+ buffers. Relationship to protein phosphorylation and diacylglycerol formation

1984 • 110 citations

Purification of a phosphoinositide-specific phospholipase C from bovine brain.

1987 • 105 citations

The effects of substance P and carbachol on inositol tris- and tetrakisphosphate formation and cytosolic free calcium in rat parotid acinar cells. A correlation between inositol phosphate levels and calcium entry.

1987 • 105 citations

Enhancement of the muscarinic synaptosomal phospholipid labeling effect by the ionophore A23187.

1981 • 101 citations

Carbachol causes rapid phosphodiesteratic cleavage of phosphatidylinositol 4,5-bisphosphate and accumulation of inositol phosphates in rabbit iris smooth muscle; prazosin inhibits noradrenaline- and ionophore A23187-stimulated accumulation of inositol phosphates

1984 • 97 citations

Magnesium Ions Inhibit the Stimulation of Inositol Phospholipid Hydrolysis by Endogenous Excitatory Amino Acids in Primary Cultures of Cerebellar Granule Cells

1987 • 85 citations

Calcium ion requirement for acetylcholine-stimulated breakdown of triphosphoinositide in rabbit iris smooth muscle.

1978 • 73 citations

Stimulation of phosphoinositide breakdown in brain synaptoneurosomes by agents that activate sodium influx: antagonism by tetrodotoxin, saxitoxin, and cadmium.

1987 • 61 citations

Protein kinase C: a key regulator of neuronal excitability?

1986 • 57 citations

Agricultural research: Towards grant competition

1984 • 3 citations