Thyrotropin-releasing hormone receptor occupancy determines the fraction of the responsive pool of inositol lipids hydrolysed in rat pituitary tumour cells

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

RECEPTORS AND PHOSPHOINOSITIDE-GENERATED SECOND MESSENGERS

1985 • 722 citations

The Metabolism of Phosphoinositide-Derived Messenger Molecules

1986 • 717 citations

The polyphosphoinositide phosphodiesterase of erythrocyte membranes

1981 • 614 citations

Sustained diacylglycerol formation from inositol phospholipids in angiotensin II-stimulated vascular smooth muscle cells.

1986 • 491 citations

Oscillations of cytosolic Ca2+ in pituitary cells due to action potentials

1987 • 331 citations

Thyrotropin-releasing hormone regulates the number of its own receptors in the GH3 strain of pituitary cells in culture

1975 • 300 citations

[46] Clonal strains of hormone-producing pituitary cells

1979 • 296 citations

Mechanism of Thyrotropin Releasing Hormone Stimulation of Pituitary Hormone Secretion

1986 • 292 citations

Phosphoinositide interconversion in thrombin-stimulated human platelets.

1985 • 205 citations

Thyroliberin stimulates rapid hydrolysis of phosphatidylinositol 4,5-bisphosphate by a phosphodiesterase in rat mammotropic pituitary cells. Evidence for an early Ca2+-independent action

1983 • 203 citations

Novel aspects of gonadotropin-releasing hormone action on inositol polyphosphate metabolism in cultured pituitary gonadotrophs.

1987 • 169 citations

Relationship between phosphatidylinositol synthesis and recovery of 5-hydroxytryptamine-responsive Ca2+ flux in blowfly salivary glands

1979 • 135 citations

Independent phosphatidylinositol synthesis in pituitary plasma membrane and endoplasmic reticulum

1987 • 132 citations

Lithium-induced reduction in intracellular inositol supply in cholinergically stimulated parotid gland

1986 • 121 citations

Bihormonal regulation of the thyrotropin-releasing hormone receptor in mouse pituitary thyrotropic tumor cells in culture.

1978 • 106 citations

The relationship of hormone-sensitive and hormone-insensitive phosphatidylinositol to phosphatidylinositol 4,5-bisphosphate in the WRK-1 cell.

1986 • 98 citations

Phosphatidylinositol 4,5-bisphosphate turnover is transient while phosphatidylinositol turnover is persistent in thyrotropin-releasing hormone-stimulated rat pituitary cells.

1986 • 90 citations

Thyrotropin-releasing hormone-stimulated [3H]inositol metabolism in GH3 pituitary tumor cells. Studies with lithium.

1984 • 89 citations

Inositol Lipid Metabolism and Signal Transduction in Clonal Pituitary Cells

1986 • 75 citations

Evidence for multiple metabolic pools of phosphatidylinositol in stimulated platelets.

1982 • 73 citations

Pituitary TRH Receptors

1989 • 65 citations

Characterization of the hormone-sensitive phosphatidylinositol pool in WRK-1 cells.

1983 • 63 citations

Turnover of phosphomonoester groups and compartmentation of polyphosphoinositides in human erythrocytes

1986 • 56 citations

Rapid temperature-dependent transformation of the thyrotropin-releasing hormone-receptor complex in rat pituitary tumor cells.

1982 • 55 citations

Measurement of lipid turnover in response to thyrotropin-releasing hormone

1987 • 51 citations

Thyrotropin-Releasing Hormone Action: Mechanism of Calcium-Mediated Stimulation of Prolactin Secretion

1985 • 51 citations

Solubilization of rat liver vasopressin receptors as a complex with a guanine-nucleotide-binding protein and phosphoinositide-specific phospholipase C

1989 • 46 citations

Inositol metabolism in WRK-1 cells. Relationship of hormone-sensitive to -insensitive pools of phosphoinositides.

1987 • 42 citations

Chlordiazepoxide is a competitive thyrotropin-releasing hormone receptor antagonist in GH3 pituitary tumour cells

1985 • 41 citations

Regulation by phosphatidylinositol of rat pituitary plasma membrane and endoplasmic reticulum phosphatidylinositol synthase activities. A mechanism for activation of phosphoinositide resynthesis during cell stimulation.

1987 • 37 citations

Evidence for Tight Coupling of Receptor Occupancy by Thyrotf opin-Releasing Hormone to Phospholipase CMediated Phosphoinositide Hydrolysis in Rat Pituitary Cells: Use of Chlordiazepoxide as a CompetitiveAntagonist*

1986 • 33 citations

Inositol lipids: receptor-stimulated hydrolysis and cellular lipid pools

1988 • 32 citations

Subcellular localization of inositol lipids in blood platelets as deduced from the use of labelled precursors

1987 • 27 citations

Protein Kinase C-mediated Gonadotropin-releasing Hormone Receptor Sequestration Is Associated with Uncoupling of Phosphoinositide Hydrolysis

1989 • 26 citations

Ca²⁺Transients Induced by Thyrotropin-Releasing Hormone Rapidly Lose Their Ability to Cause Release of Prolactin

1989 • 22 citations

Phosphatidylinositol Depletion in GH₃Rat Pituitary Cells Inhibits Sustained Responses to Thyrotropin-Releasing Hormone. Reversal withmyo-inositol

1987 • 14 citations

Thyrotropin-releasing hormone-stimulated inositol trisphosphate formation is liable to thyrotropin-releasing hormone-induced desensitization by a calcium-dependent mechanism

1988 • 12 citations

Sphingosine Interacts Directly with the Receptor Complex to Inhibit Thyrotropin-Releasing Hormone Binding

1990 • 11 citations

Solubilization of Receptors for Thyrotropin-Releasing Hormone from GH₄C₁Rat Pituitary Cells: Demonstration of Guanyl Nucleotide Sensitivity

1987 • 11 citations

Kinetic analysis of thyrotropin-releasing hormone binding in the central nervous system: evidence for receptor desensitization

1987 • 9 citations

The interaction of benzodiazepines with thyrotropin‐releasing hormone receptors on clonal pituitary cells

1989 • 7 citations