Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

The Role of Polyamines in the Neutralization of Bacteriophage Deoxyribonucleic Acid

1960 • 2,598 citations

Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

1983 • 1,937 citations

Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol

1983 • 1,104 citations

The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain.

1980 • 1,099 citations

A simple graphical method for determining the inhibition constants of mixed, uncompetitive and non-competitive inhibitors (Short Communication)

1974 • 908 citations

Micro-injection of inositol 1,3,4,5-tetrakisphosphate activates sea urchin eggs by a mechanism dependent on external Ca2+

1986 • 775 citations

RECEPTORS AND PHOSPHOINOSITIDE-GENERATED SECOND MESSENGERS

1985 • 722 citations

The Metabolism of Phosphoinositide-Derived Messenger Molecules

1986 • 717 citations

The inositol tris/tetrakisphosphate pathway—demonstration of Ins(l,4,5)P3 3-kinase activity in animal tissues

1986 • 702 citations

Rapid formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor stimulation of rat cerebral cortical slices

1985 • 641 citations

Relationship between inositol polyphosphate production and the increase of cytosolic free Ca2+ induced by vasopressin in isolated hepatocytes.

1984 • 358 citations

Stepwise enzymatic dephosphorylation of inositol 1,4,5-trisphosphate to inositol in liver

1984 • 321 citations

Intracellular Ca2+ mobilization by arachidonic acid. Comparison with myo-inositol 1,4,5-trisphosphate in isolated pancreatic islets.

1986 • 310 citations

Inositol trisphosphates in carbachol-stimulated rat parotid glands

1984 • 296 citations

Inositol 1,3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-bisphosphate is the probable precursor of inositol 1,3,4-trisphosphate in agonist-stimulated parotid gland

1986 • 283 citations

Formation and metabolism of inositol 1,3,4,5-tetrakisphosphate in liver.

1986 • 280 citations

Identification and properties of two distinct phosphatidylinositol-specific phospholipase C enzymes from sheep seminal vesicular glands.

1982 • 248 citations

Inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate formation in Ca2+-mobilizing-hormone-activated cells

1985 • 234 citations

Isolation of a phosphomonoesterase from human platelets that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate.

1985 • 233 citations

Hydrolysis of polyphosphoinositides by purified sheep seminal vesicle phospholipase C enzymes.

1984 • 225 citations

Rapid formation of inositol 1,3,4,5-tetrakisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands may both result indirectly from receptor-stimulated release of inositol 1,4,5-trisphosphate from phosphatidylinositol 4,5-bisphosphate

1986 • 224 citations

Short Communication Inositol Tetrakis- And Pentakisphosphates In Gh4 Cells

1985 • 201 citations

Specificity of inositol phosphate-stimulated Ca2+ mobilization from Swiss-mouse 3T3 cells

1986 • 190 citations

Effects of bombesin and insulin on inositol (1,4,5) trisphosphate and inositol (1,3,4) trisphosphate formation in Swiss 3T3 cells

1986 • 185 citations

Ca2+ regulates the inositol tris/tetrakisphosphate pathway in intact and broken preparations of insulin-secreting RINm5F cells.

1986 • 177 citations

Novel aspects of gonadotropin-releasing hormone action on inositol polyphosphate metabolism in cultured pituitary gonadotrophs.

1987 • 169 citations

The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes.

1987 • 164 citations

Modulation of phosphatidylinositol-specific phospholipase C activity by phospholipid interactions, diglycerides, and calcium ions.

1982 • 158 citations

Ca2+-mediated generation of inositol 1,4,5-triphosphate and inositol 1,3,4,5-tetrakisphosphate in pancreatic islets. Studies with K+, glucose, and carbamylcholine.

1987 • 157 citations

Why is uncompetitive inhibition so rare?

1986 • 156 citations

Guanine nucleotides stimulate soluble phosphoinositide-specific phospholipase C in the absence of membranes.

1986 • 116 citations

Pathway for inositol 1,3,4-trisphosphate and 1,4-bisphosphate metabolism.

1987 • 115 citations

Dephosphorylation of myo-inositol 1,4,5-trisphosphate and myo-inositol 1,3,4-triphosphate

1987 • 111 citations

Inositol bis-, tris-, and tetrakis(phosphate)s: analysis in tissues by HPLC.

1986 • 93 citations

Purification and Properties of myo-Inositol-1-Phosphatase from Rat Brain

1985 • 86 citations

The metabolism of inositol 1,3,4-trisphosphate to inositol 1,3-bisphosphate.

1987 • 82 citations

Angiotensin-stimulated production of inositol trisphosphate isomers and rapid metabolism through inositol 4-monophosphate in adrenal glomerulosa cells.

1986 • 81 citations

The role of cytosolic free calcium in the generation of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in HL-60 cells. Differential effects of chemotactic peptide receptor stimulation at distinct Ca2+ levels.

1986 • 71 citations

Glucose-induced accumulation of inositol trisphosphates in isolated pancreatic islets. Predominance of the 1,3,4-isomer

1986 • 67 citations

Isomers of inositol trisphosphate in exocrine pancreas

1986 • 55 citations

Inositol(3,4)bisphosphate and inositol(1,3)bisphosphate in GH4 cells - evidence for complex breakdown of inositol(1,3,4)trisphosphate

1987 • 50 citations

Perturbation of the human T-cell antigen receptor-T3 complex leads to the production of inositol tetrakisphosphate: evidence for conversion from inositol trisphosphate.

1986 • 46 citations

Electrophysiological responses to bradykinin and microinjected inositol polyphosphates in neuroblastoma cells

1987 • 46 citations

Angiotensin-induced formation and metabolism of inositol polyphosphates in bovine adrenal glomerulosa cells

1987 • 45 citations

Evidence for the formation of inositol 4‐monophosphate in stimulated human platelets

1985 • 42 citations

Metabolism of inositol 1,4,5-trisphosphate in guinea-pig hepatocytes

1987 • 35 citations

Enzymic dephosphorylation of <scp>d</scp>-myo-inositol 1,4-bisphosphate in rat brain

1987 • 23 citations

Production of inositol trisphosphates and inositol tetrakisphosphate in stimulated pancreatic islets

1987 • 22 citations

Identification of a novel inositol bisphosphate isomer formed in chemoattractant stimulated human polymorphonuclear leukocytes

1987 • 20 citations

The metabolism of inositol 4-monophosphate in rat mammalian tissues

1987 • 20 citations