IL-13 suppresses TNF-induced activation of nuclear factor-kappa B, activation protein-1, and apoptosis.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1993 • 1,330 citations

Production of hybridoma growth factor by human monocytes

1987 • 1,133 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells.

1993 • 1,084 citations

lnterleukin-13 is a new human lymphokine regulating inflammatory and immune responses

1993 • 877 citations

Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

1997 • 791 citations

Prolonged activation of jun and collagenase genes by tumour necrosis factor-α

1989 • 726 citations

Activation of the IκBα Kinase Complex by MEKK1, a Kinase of the JNK Pathway

1997 • 712 citations

Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-gamma or IL-10.

1993 • 657 citations

NF-kappa B as a frequent target for immunosuppressive and anti-inflammatory molecules.

1997 • 576 citations

Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function.

1993 • 565 citations

Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2

1997 • 552 citations

Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction.

1993 • 457 citations

TRAF2 Is Essential for JNK but Not NF-κB Activation and Regulates Lymphocyte Proliferation and Survival

1997 • 449 citations

Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis.

1996 • 352 citations

Interleukin 13 is a B cell stimulating factor.

1994 • 298 citations

Sanguinarine (Pseudochelerythrine) Is a Potent Inhibitor of NF-κB Activation, IκBα Phosphorylation, and Degradation

1997 • 281 citations

Cloning and Characterization of a Specific Interleukin (IL)-13 Binding Protein Structurally Related to the IL-5 Receptor α Chain

1996 • 278 citations

IL-13 induces proliferation and differentiation of human B cells activated by the CD40 ligand

1993 • 260 citations

Molecular Mechanisms of c-Jun N-terminal Kinase-mediated Apoptosis Induced by Anticarcinogenic Isothiocyanates

1998 • 239 citations

Human glioma cells overexpress receptors for interleukin 13 and are extremely sensitive to a novel chimeric protein composed of interleukin 13 and pseudomonas exotoxin.

1995 • 215 citations

Triggering of the Human Interleukin-6 Gene by Interferon-γ and Tumor Necrosis Factor-α in Monocytic Cells Involves Cooperation between Interferon Regulatory Factor-1, NFκB, and Sp1 Transcription Factors

1995 • 213 citations

NF-κB-mediated Induction of mdr1b Expression by Insulin in Rat Hepatoma Cells

1997 • 191 citations

IL-4 and IL-13 receptors: are they one and the same?

1996 • 188 citations

Overexpression of the p80 TNF receptor leads to TNF-dependent apoptosis, nuclear factor-kappa B activation, and c-Jun kinase activation.

1998 • 163 citations

IL-13 protects mice from lipopolysaccharide-induced lethal endotoxemia: correlation with down-modulation of TNF-alpha, IFN-gamma, and IL-12 production.

1997 • 161 citations

Alloreactive cytotoxic T lymphocytes generated in the presence of viral-derived peptides show exquisite peptide and MHC specificity.

1993 • 150 citations

Interleukin-4 Suppression of Tumor Necrosis Factor α-stimulated E-selectin Gene Transcription Is Mediated by STAT6 Antagonism of NF-κB

1997 • 149 citations

Interleukin-13 Signal Transduction in Lymphohemopoietic Cells

1995 • 145 citations

Tumor necrosis factor and lymphotoxin. Qualitative and quantitative differences in the mediation of early and late cellular response.

1994 • 130 citations

Protein-tyrosine Phosphatase Inhibitors Block Tumor Necrosis Factor-dependent Activation of the Nuclear Transcription Factor NF-kB

1995 • 123 citations

IκBα Overexpression in Human Breast Carcinoma MCF7 Cells Inhibits Nuclear Factor-κB Activation but Not Tumor Necrosis Factor-α-induced Apoptosis

1997 • 121 citations

Interleukin 13 inhibits human immunodeficiency virus type 1 production in primary blood-derived human macrophages in vitro.

1993 • 106 citations

Tissue-specific regulation of IL-6 production by IL-4. Differential effects of IL-4 on nuclear factor-kappa B activity in monocytes and fibroblasts.

1993 • 93 citations

Protective effects of IL-4, IL-10, IL-12, and IL-13 in IgG immune complex-induced lung injury: role of endogenous IL-12.

1997 • 87 citations

Activation of Phosphatidylinositol 3-Kinase by Interleukin-13

1997 • 85 citations

Interleukin-13 in Combination With CD40 Ligand Potently Inhibits Apoptosis in Human B Lymphocytes: Upregulation of Bcl-xL and Mcl-1

1997 • 81 citations

Mechanism of suppression of macrophage nitric oxide release by IL-13: influence of the macrophage population.

1997 • 78 citations

Interleukin-13 Inhibits Protein Kinase C-triggered Respiratory Burst in Human Monocytes

1995 • 53 citations

Modulation of Interleukin (IL)-13 Binding and Signaling by the γc Chain of the IL-2 Receptor

1997 • 52 citations

Inhibition of nitric oxide synthesis by interleukin‐4 may involve inhibiting the activation of protein kinase C epsilon

1994 • 48 citations

Interleukin 13 and Interleukin 4 Protect Bronchoalveolar Macrophages from Productive Infection with Human Immunodeficiency Virus Type 1

1994 • 38 citations

Interleukin 4 potentiates the antiproliferative effects of tumor necrosis factor on various tumor cell lines.

1991 • 36 citations

IL-4 upregulates IL-1-induced chemokine gene expression in bone marrow stromal cells by enhancing NF-kB activation.

1996 • 8 citations