Cyclin D1 and human neoplasia

A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group [see comments]

1994 • 6,495 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

G1 phase progression: Cycling on cue

1994 • 2,706 citations

Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells

2005 • 2,216 citations

Cyclins and cancer II: Cyclin D and CDK inhibitors come of age

1994 • 2,122 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

A novel cyclin encoded by a bcl1-linked candidate oncogene

1991 • 1,286 citations

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

1993 • 1,258 citations

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.

1993 • 1,057 citations

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1993 • 1,047 citations

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

1992 • 1,031 citations

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

1989 • 1,031 citations

Cyclin D1 provides a link between development and oncogenesis in the retina and breast

1995 • 1,017 citations

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

1989 • 990 citations

Acceleration of the G₁/S Phase Transition by Expression of Cyclins Dl and E with an Inducible System

1994 • 986 citations

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

1989 • 931 citations

Structural Evidence for the Authenticity of the Human Retinoblastoma Gene

1987 • 809 citations

Physical interaction of the retinoblastoma protein with human D cyclins

1993 • 780 citations

Cyclin-Dependent Regulation of G ₁ in Mammalian Fibroblasts

1993 • 767 citations

Genetic Alterations of Cyclins, Cyclin-Dependent Kinases, and Cdk Inhibitors in Human Cancer

1996 • 751 citations

CDK-Independent Activation of Estrogen Receptor by Cyclin D1

1997 • 698 citations

Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

1995 • 681 citations

Prognostic classification of breast ductal carcinoma-in-situ

1995 • 678 citations

Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining.

1994 • 673 citations

Expression and amplification of cyclin genes in human breast cancer.

1993 • 667 citations

Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system.

1994 • 659 citations

The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity

1987 • 649 citations

Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia.

1995 • 549 citations

Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product

1991 • 541 citations

Mantle Cell Lymphoma A Proposal for Unification of Morphologic, Immunologic, and Molecular Data

1992 • 519 citations

Cyclin D1 protein expression and function in human breast cancer

1994 • 515 citations

The spread of tumors in the human body

1935 • 487 citations

PRAD1, a candidate BCL1 oncogene: mapping and expression in centrocytic lymphoma.

1991 • 454 citations

Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein.

1987 • 432 citations

Amplification and expression of the human cyclin D gene in esophageal cancer.

1992 • 411 citations

Role of the cyclin-dependent kinase inhibitors in the development of cancer

1995 • 404 citations

Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression.

1993 • 393 citations

D11S287, a putative oncogene on chromosome 11q13, is amplified and expressed in squamous cell and mammary carcinomas and linked to BCL-1.

1991 • 376 citations

Overexpression of cyclin D1 correlates with recurrence in a group of forty-seven operable squamous cell carcinomas of the head and neck.

1995 • 368 citations

Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer.

1993 • 367 citations

Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

1997 • 359 citations

Characterization of a candidate bcl-1 gene.

1991 • 357 citations

PRAD-1/cyclin D1 gene overexpression in chronic lymphoproliferative disorders: a highly specific marker of mantle cell lymphoma

1994 • 353 citations

Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions

1995 • 334 citations

Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product

1991 • 334 citations

Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma.

1994 • 327 citations

Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas.

1992 • 322 citations

Role of the cyclin-dependent kinase inhibitors in the development of cancer

1995 • 321 citations

Increased expression of cyclin D1 is an early event in multistage colorectal carcinogenesis

1996 • 318 citations

Cyclin D1 and prognosis in human breast cancer

1996 • 318 citations

Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression.

1994 • 280 citations

DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1.

1994 • 279 citations

The involvement of the chromosome 11q13 region in human malignancies: Cyclin D1 and EMS1 are two new candidate oncogenes-a review

1995 • 276 citations

PRAD-1/cyclin D1 gene amplification correlates with messenger RNA overexpression and tumor progression in human laryngeal carcinomas.

1994 • 263 citations

Overexpression of cyclin D1 in human pancreatic carcinoma is associated with poor prognosis.

1997 • 260 citations

PRAD-1 (CCND1)/Cyclin D1 oncogene amplification in primary head and neck squamous cell carcinoma

1994 • 242 citations

Abnormal patterns of D-type cyclin expression and G1 regulation in human head and neck cancer.

1995 • 238 citations

Amplification and Overexpression of Cyclin D1 in Human Hepatocellular Carcinoma

1993 • 237 citations

Cyclin D1 expression is regulated by the retinoblastoma protein.

1994 • 235 citations

Antisense to cyclin D1 inhibits the growth and tumorigenicity of human colon cancer cells.

1997 • 227 citations

CDK4 amplification is an alternative mechanism to p16 gene homozygous deletion in glioma cell lines.

1994 • 221 citations

Prognostic significance of CCND1 (cyclin D1) overexpression in primary resected non-small-cell lung cancer

1996 • 217 citations

Determination of the prognostic value of cyclin D1 overexpression in breast cancer.

1995 • 215 citations

Amplification of cyclin D1 in squamous cell carcinoma of the head and neck and the prognostic value of chromosomal abnormalities and cyclin D1 overexpression

1997 • 210 citations

Cyclin D1 expression in invasive breast cancer. Correlations and prognostic value.

1997 • 207 citations

Cyclin D1 oncoprotein aberrantly accumulates in malignancies of diverse histogenesis.

1995 • 207 citations

Tumor suppressor genes

1994 • 206 citations

Amplification of cyclin genes in colorectal carcinomas.

1993 • 197 citations

Molecular genetic studies of sporadic pituitary tumors.

1994 • 195 citations

Amplification of genes within the chromosome 11q13 region is indicative of poor prognosis in patients with operable breast cancer.

1992 • 194 citations

Cyclin D1 protein analysis in the diagnosis of mantle cell lymphoma

1995 • 194 citations

Cyclin D1/PRAD1 expression in parathyroid adenomas: an immunohistochemical study.

1996 • 190 citations

Absence of cyclin D/cdk complexes in cells lacking functional retinoblastoma protein.

1994 • 185 citations

Blastoid variants of mantle cell lymphoma: frequent bcl-1 rearrangements at the major translocation cluster region and tetraploid chromosome clones.

1997 • 182 citations

A clinicopathological study on overexpression of cyclin D1 and of p53 in a series of 248 patients with operable breast cancer

1996 • 181 citations

Cyclin gene amplification and overexpression in breast and ovarian cancers: Evidence for the selection ofcyclin D1 in breast andcyclin E in ovarian tumors

1996 • 180 citations

Overexpression of Cyclin D1 Indicates a Poor Prognosis in Squamous Cell Carcinoma of the Head and Neck

1997 • 175 citations

Blastoid Variants of Mantle Cell Lymphoma: Frequent bcl-1 Rearrangements at the Major Translocation Cluster Region and Tetraploid Chromosome Clones

1997 • 169 citations

High incidence of coamplification of hst-1 and int-2 genes in human esophageal carcinomas.

1989 • 162 citations

Proto-oncogene amplification and human breast tumor phenotype

1990 • 154 citations

Rearrangement and overexpression of the BCL-1/PRAD-1 gene in intermediate lymphocytic lymphomas and in t(11q13)-bearing leukemias

1993 • 152 citations

Deregulation of cyclin E and D1 in breast cancer is associated with inactivation of the retinoblastoma protein

1997 • 150 citations

The targeting of the cyclin D1 oncogene by an Epstein-Barr virus promoter in transgenic mice causes dysplasia in the tongue, esophagus and forestomach

1997 • 143 citations

Antisense to cyclin D1 inhibits growth and reverses the transformed phenotype of human esophageal cancer cells.

1995 • 143 citations

Overexpression and localization of cyclin D1 mRNA and antigen in esophageal cancer.

1995 • 142 citations

Significance of int-2/hst-1 coamplification as a prognostic factor in patients with esophageal squamous carcinoma.

1991 • 137 citations

Amplification at chromosome 11q13 in transitional cell tumours of the bladder.

1991 • 135 citations

Amplification of FGF-related genes in human tumors: possible involvement of HST in breast carcinomas.

1989 • 134 citations

Rearrangement of CCND1 (BCL1/PRAD1) 3' untranslated region in mantle- cell lymphomas and t(11q13)-associated leukemias

1994 • 131 citations

Cyclin D1 messenger RNA overexpression as a marker for mantle cell lymphoma.

1995 • 126 citations

Immunohistochemistry of Cyclin D1 in Human Breast Cancer

1994 • 125 citations

Association of INT2/HST1 coamplification in primary breast cancer with hormone-dependent phenotype and poor prognosis

1991 • 124 citations

Cyclin D1 amplification as a new predictive classification for squamous cell carcinoma of the esophagus, adding gene information.

1996 • 124 citations

Prevalence of amplification of the oncogenes c-myc, HER2/neu, and int-2 in one thousand human breast tumours: Correlation with steroid receptors

1992 • 123 citations

Cell cycle: Routine role for Ras

1997 • 123 citations

Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients.

1997 • 119 citations

Gene amplification on chromosome band 11q13 and oestrogen receptor status in breast cancer

1990 • 118 citations

The D-type cyclins and their role in tumorigenesis

1994 • 116 citations

Coding sequence of the overexpressed transcript of the putative oncogene PRAD1/cyclin D1 in two primary human tumors.

1993 • 107 citations

Homozygous deletion frequency and expression levels of the CDKN2 gene in human sarcomas - relationship to amplification and mRNA levels of CDK4 and CCND1

1995 • 106 citations

Significance of cyclin D1 overexpression in transitional cell carcinomas of the urinary bladder and its correlation with histopathologic features

1997 • 104 citations

Expression of cyclin D1 protein in centrocytic/mantle cell lymphomas with and without rearrangement of the BCL1/Cyclin D1 gene*1, *2

1995 • 104 citations

Cyclin D1 overexpression in primary hypopharyngeal carcinomas

1996 • 99 citations

Overexpression of Cyclin D1 in Epithelial Ovarian Cancers

1997 • 98 citations

Changes in p⁵³ and cyclin D1 protein levels and cell proliferation in different stages of human esophageal and gastric‐cardia carcinogenesis

1994 • 96 citations

Dietary estrogens stimulate human breast cells to enter the cell cycle.

1997 • 93 citations

Amplification of CCND1 and expression of its protein product, cyclin D1, in ductal carcinoma in situ of the breast.

1997 • 84 citations

Overexpression of cyclin D1 correlates with early recurrence in superficial bladder cancers

1997 • 83 citations

Overexpression of cyclin D1 and p53 associated with disease recurrence in colorectal adenocarcinoma

1997 • 82 citations

A homozygous deletion in a small cell lung cancer cell line involving a 3p21 region with a marked instability in yeast artificial chromosomes

1995 • 76 citations

Characterization of a Candidate bcl-1 Gene

1991 • 73 citations

Cyclin-d1-gene amplification and expression in breast carcinoma: Relation with clinicopathologic characteristics and with retinoblastoma gene product, p53 and p21waf1 immunohistochemical expression

1997 • 73 citations

Oncogene amplification correlates with dense lymphocyte infiltration in human breast cancers: A role for hematopoietic growth factor release by tumor cells?

1990 • 72 citations

CYCLIN D1 OVEREXPRESSION IN NON-SMALL CELL LUNG CARCINOMA: CORRELATION WITH Ki67 LABELLING INDEX AND POOR CYTOPLASMIC DIFFERENTIATION

1996 • 71 citations

Molecular and immunohistochemical analysis of the bcl-1/cyclin D1 gene in laryngeal squamous cell carcinomas: correlation of protein expression with lymph node metastases and advanced clinical stage.

1997 • 70 citations

Coabnormal expression of cyclin D1 and p53 protein in human uterine endometrial carcinomas

1996 • 69 citations

Cyclin D1 protein in multiple myeloma and plasmacytoma: an immunohistochemical study using fixed, paraffin-embedded tissue sections.

1997 • 69 citations

PRAD1 gene over‐expression in mantle‐cell lymphoma but not in other low‐grade B‐cell lymphomas, including extranodal lymphoma

1994 • 68 citations

An additional breakpoint region in the BCL-1 locus associated with the t(11;14)(q13;q32) translocation of B-lymphocytic malignancy

1989 • 68 citations

Co-amplification of integrated hepatitis B virus DNA and transforming gene hst-1 in a hepatocellular carcinoma.

1988 • 65 citations

Gossypol inhibition of mitosis, cyclin D1 and Rb protein in human mammary cancer cells and cyclin-D1 transfected human fibrosarcoma cells

1997 • 65 citations

bcl-l Rearrangement and Cyclin Dl Protein Expression in Multiple Lymphomatous Polyposis

1996 • 61 citations

COAMPLIFICATION OF THE hst‐1 AND int‐2 GENES IN HUMAM CANCERS

1988 • 61 citations

Clinical significance of cyclin D1 expression in patients with node-positive breast carcinoma treated with adjuvant therapy

1996 • 60 citations

Relevance of cyclin D1 and other molecular markers to cancer chemoprevention

1996 • 58 citations

Monoclonal Antibody against PRADl/Cyclin Dl Stains Nuclei of Tumor Cells with Translocation or Amplification at BCL‐1 Locus

1994 • 57 citations

Abnormalities in thePRAD1 (CYCLIN D1 /BCL-1) oncogene are frequent in cervical and vulvar squamous cell carcinoma cell lines

1995 • 55 citations

Frequent amplification of the bcl-1 locus in poorly differentiated squamous cell carcinoma of the lung. The Lung Cancer Study Group.

1990 • 55 citations

Immunohistochemical Analysis of Cyclin D1 Protein in Hematopoietic Neoplasms with Special Reference to Mantle Cell Lymphoma

1994 • 51 citations

Cyclin D1 in mammary carcinoma

1997 • 51 citations

Abnormal expression of CCNDI and RBI in resection margin epithelia of lung cancer patients

1997 • 51 citations

Molecular and immunohistochemical analysis of thebcl-1/cyclin D1 gene in laryngeal squamous cell carcinomas

1997 • 50 citations

Expression of cyclin D1 and c-Ki-ras gene product in human epithelial ovarian tumors

1996 • 48 citations

Expression of cyclin D1 correlates with malignancy in human ovarian tumours

1997 • 47 citations

Enhanced protein stability: a novel mechanism of D-type cyclin over-abundance identified in human sarcoma cells.

1996 • 47 citations

Oncogene amplifications in early‐stage human prostate carcinomas

1994 • 43 citations

The Positive Nuclear Staining Observed with Monoclonal Antibody against PRAD1/Cyclin D1 Correlates with mRNA Expression in Mantle Cell Lymphoma

1995 • 43 citations

Cellular and Molecular Mechanisms of Hepatocarcinogenesis Associated with Hepadnavirus Infection

1991 • 42 citations

Cyclin and Cyclin-Dependent Kinase Expression in Human Astrocytoma Cell Lines

1997 • 39 citations

Microdeletion associated with the integration process of hepatitis B virus DNA

1988 • 37 citations

Cyclin D1 gene expression in human cervical neoplasia.

1996 • 37 citations

Immunohistochemical detection and gene amplification of cyclin D1 in mammary infiltrating ductal carcinoma.

1996 • 36 citations

Increased expression of G1 cyclins and cyclin-dependent kinases during tumor progression of chemically induced mouse skin neoplasms

1997 • 35 citations

Increased expression of G1 cyclins and cyclin-dependent kinases during tumor progression of chemically induced mouse skin neoplasms.

1997 • 35 citations

Tumour Suppressor Genes in the Pathogenesis of Human Pituitary Tumours

1997 • 33 citations

Expression of Cyclin D1 and p53 Protein in Various Malignant Skin Tumors

1996 • 32 citations

The prognostic value of NCAM, p53 and cyclin D1 in resected non-small cell lung cancer

1996 • 31 citations

Temporal expressions of cyclins and cyclin dependent kinases during renal development and compensatory growth

1997 • 25 citations

Cyclin D1 protein expression in lung cancer

1996 • 24 citations

Analysis of phosphorylation of pRB and its regulatory proteins in breast cancer.

1997 • 20 citations

Significance of Cyclin D1 Overexpression in Transitional Cell Carcinomas of the Urinary Bladder and its Correlation With Histopathologic Features

1998 • 17 citations

<italic>HST</italic>1 and <italic>INT</italic>2 Gene Coamplification in a Squamous Cell Carcinoma of the Gallbladder

1989 • 17 citations

Immunostaining of PRAD1/cyclin D1 protein as a marker for the diagnosis of mantle cell lymphoma.

1997 • 14 citations

Cyclin D1 and retinoblastoma protein expression in oesophageal squamous cell carcinoma.

1997 • 14 citations

Clinical aspects of B-cell malignancy involving the BCL1/PRAD1 locus.

1994 • 13 citations

The cell cycle and cancer

1995 • 5 citations

Clinical aspects of B-cell malignancy involving the BCL1/PRAD1 locus

1995 • 1 citations