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Transcription factors as targets for cancer therapy

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Levels of TGF-α and EGFR Protein in Head and Neck Squamous Cell Carcinoma and Patient Survival

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Severe Liver Degeneration in Mice Lacking the IκB Kinase 2 Gene

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The IKKβ Subunit of IκB Kinase (IKK) is Essential for Nuclear Factor κB Activation and Prevention of Apoptosis

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Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer.

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The Transcriptional Activity of NF-κB Is Regulated by the IκB-Associated PKAc Subunit through a Cyclic AMP–Independent Mechanism

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IκB Kinases Phosphorylate NF-κB p65 Subunit on Serine 536 in the Transactivation Domain

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Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity.

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Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound.

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Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor–κB and IκBα kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis

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Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-κB activation via the NIK/IKK signalling complex

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Curcumin Blocks Cytokine-Mediated NF-κB Activation and Proinflammatory Gene Expression by Inhibiting Inhibitory Factor I-κB Kinase Activity

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Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer.

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Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines

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Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl

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Distinct Roles of the IκB Kinase α and β Subunits in Liberating Nuclear Factor κB (NF-κB) from IκB and in Phosphorylating the p65 Subunit of NF-κB

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Curcumin Induces Apoptosis in Human Melanoma Cells through a Fas Receptor/Caspase-8 Pathway Independent of p53

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Curcuminoids Inhibit the Angiogenic Response Stimulated by Fibroblast Growth Factor-2, Including Expression of Matrix Metalloproteinase Gelatinase B

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Curcumin (Diferuloylmethane) Inhibition of Tumor Necrosis Factor (TNF)-Mediated Adhesion of Monocytes to Endothelial Cells by Suppression of Cell Surface Expression of Adhesion Molecules and of Nuclear Factor-κB Activation

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[53] Assay for redox-sensitive transcription factor

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Coexpression of proangiogenic factors IL-8 and VEGF by human head and neck squamous cell carcinoma involves coactivation by MEK-MAPK and IKK-NF-kappaB signal pathways.

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The inhibitory effect of curcumin, genistein, quercetin and cisplatin on the growth of oral cancer cells in vitro.

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Identification of a new serine kinase that activates NF kappa B by direct phosphorylation.

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Clinical development of leukocyte cyclooxygenase 2 activity as a systemic biomarker for cancer chemopreventive agents.

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Specific inhibition of cyclooxygenase‐2 results in inhibition of proliferation of oral cancer cell lines via suppression of prostaglandin E₂ production

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Expression of 92-kDa type IV collagenase correlates with angiogenic markers and poor survival in head and neck squamous cell carcinoma.

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Effects of interleukin-1alpha, interleukin-1 receptor antagonist, and neutralizing antibody on proinflammatory cytokine expression by human squamous cell carcinoma lines.

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An intervention study of tobacco chewing and smoking habits for primary prevention of oral cancer among 12,212 Indian villagers.

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Retinoids in Head and Neck Chemoprevention

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