Cytoskeletal control of gene expression: depolymerization of microtubules activates NF-kappa B.

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels

1982 • 2,259 citations

NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control

1989 • 1,622 citations

How does the extracellular matrix direct gene expression?

1982 • 1,475 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway

1993 • 1,141 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

The inducible transcription activator NF-κB: regulation by distinct protein subunits

1991 • 1,079 citations

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.

1993 • 1,047 citations

IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System

1993 • 967 citations

The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product

1990 • 900 citations

Cloning of the p50 DNA binding subunit of NF-κB: Homology to rel and dorsal

1990 • 870 citations

Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activity

1991 • 746 citations

I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention.

1992 • 731 citations

NF-kappa B activation by ultraviolet light not dependent on a nuclear signal

1993 • 646 citations

Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.

1993 • 639 citations

DNA binding and IκB inhibition of the cloned p65 subunit of NF-κB, a rel-related polypeptide

1991 • 604 citations

Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop.

1993 • 600 citations

Nuclear protein migration involves two steps: Rapid binding at the nuclear envelope followed by slower translocation through nuclear pores

1988 • 551 citations

Regulation of the NF-ηB/rel transcription factor and IηB inhibitor system

1993 • 541 citations

Nuclear import can be separated into distinct steps in vitro: Nuclear pore binding and translocation

1988 • 535 citations

Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins

1990 • 528 citations

Isolation of a rel -related Human cDNAThat Potentially Encodes the 65-kD Subunit of NF-κB

1991 • 448 citations

The effects of methyl (5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl) carbamate, (R 17934; NSC 238159), a new synthetic antitumoral drug interfering with microtubules, on mammalian cells cultured in vitro.

1976 • 422 citations

NF-κB and related proteins: Rel/dorsal homologies meet ankyrin-like repeats

1992 • 415 citations

Cloning of an NF-κB subunit which stimulates HIV transcription in synergy with p65

1991 • 410 citations

Taxol induces the assembly of free microtubules in living cells and blocks the organizing capacity of the centrosomes and kinetochores.

1981 • 397 citations

Nuclear uptake control of NF-kappa B by MAD-3, an I kappa B protein present in the nucleus.

1993 • 330 citations

In vivo control of NF-kappa B activation by I kappa B alpha.

1993 • 326 citations

Correlation between effects of 24 different cytochalasins on cellular structures and cellular events and those on actin in vitro

1982 • 316 citations

p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction.

1993 • 291 citations

NF-kappa B contacts DNA by a heterodimer of the p50 and p65 subunit.

1991 • 287 citations

Spatial relationships of microtubule-organizing centers and the contact area of cytotoxic T lymphocytes and target cells.

1982 • 283 citations

Dependence of liver-specific transcription on tissue organization.

1985 • 230 citations

Tumor Necrosis Factor and Interleukin-1 Lead to Phosphorylation and Loss of IκBα: a Mechanism for NF-κB Activation

1993 • 223 citations

The riddle of morphogenesis: A question of solution chemistry or molecular cell engineering?

1993 • 219 citations

Brain ankyrin. A membrane-associated protein with binding sites for spectrin, tubulin, and the cytoplasmic domain of the erythrocyte anion channel.

1984 • 215 citations

Animal cell shape changes and gene expression

1991 • 212 citations

Tubulin sulfhydryl groups as probes and targets for antimitotic and antimicrotubule agents

1991 • 205 citations

Evidence that microtubule depolymerization early in the cell cycle is sufficient to initiate DNA synthesis

1981 • 202 citations

A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene.

1992 • 171 citations

The IκB proteins: members of a multifunctional family

1993 • 169 citations

Microtubule stabilization by taxol inhibits initiation of DNA synthesis by thrombin and by epidermal growth factor

1981 • 157 citations

Characterization of a Functional NF-κB Site in the Human Interleukin 1β Promoter: Evidence for a Positive Autoregulatory Loop

1993 • 156 citations

Intrinsic microtubule stability in interphase cells

1994 • 113 citations

Common structural constituents confer I kappa B activity to NF-kappa B p105 and I kappa B/MAD-3.

1993 • 92 citations

Microtubule assembly in living cells after release from nocodazole block: The effects of metabolic inhibitors, taxol and PH

1981 • 89 citations

Ubiquitin is a component of the microtubule network.

1988 • 88 citations

Disruption of cytoskeletal structures results in the induction of the urokinase-type plasminogen activator gene expression.

1990 • 76 citations

Dependence of Liver-Specific Transcription on Tissue Organization

1985 • 72 citations

Mitosis: basic concepts

1989 • 69 citations

Disruption of microtubule network in human monocytes induces expression of interleukin-1 but not that of interleukin-6 nor tumor necrosis factor-alpha. Involvement of protein kinase A stimulation

1993 • 59 citations

Cytoskeletal reorganizations in human umbilical vein endothelial cells as a result of cytokine exposure

1991 • 56 citations

Cytoskeletal reorganization and TPA differently modify AP-1 to induce the urokinase-type plasminogen activator gene in LLC-PK₁cells

1993 • 55 citations

Tyrosine-phosphorylation of tubulin during monocytic differentiation of HL-60 cells.

1993 • 51 citations

Role of the cytoskeleton during injury‐induced cell migration in corneal endothelium

1990 • 50 citations

Activation of microtubule-associated protein kinase by microtubule disruption in quiescent rat 3Y1 cells

1991 • 40 citations

Regulation of microtubule assembly in cultured fibroblasts.

1980 • 38 citations

Immunofluorescent localization of the ubiquitin-activating enzyme, E1, to the nucleus and cytoskeleton

1993 • 34 citations

Stimulation of human interleukin 1 production and specific mRNA expression by microtubule-disrupting drugs

1990 • 32 citations

Colchicine has opposite effects on interleukin-1 beta and tumor necrosis factor-alpha production

1991 • 30 citations

Changes in the Extent of Microtubule Assembly Can Regulate Initiation of DNA Synthesisa

1986 • 16 citations

A novel T-cell trans-activator that recognizes a phorbol ester-inducible element of the interleukin-2 promoter.

1990 • 13 citations