Intrinsic tumour suppression

Surfing the p53 network

2000 • 6,487 citations

The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

2002 • 5,914 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

Cell Death

2004 • 4,599 citations

The Pathophysiology of Mitochondrial Cell Death

2004 • 3,258 citations

Proliferation, cell cycle and apoptosis in cancer

2001 • 3,236 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

Apoptosis

2002 • 2,190 citations

Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence

2003 • 2,104 citations

p53 Has a Direct Apoptogenic Role at the Mitochondria

2003 • 1,735 citations

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

1997 • 1,568 citations

The Bcl-2 family: roles in cell survival and oncogenesis

2003 • 1,448 citations

Control of apoptosis by p53

2003 • 1,343 citations

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1998 • 1,248 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF

1999 • 1,068 citations

The CD95(APO-1/Fas) DISC and beyond

2003 • 1,064 citations

A Senescence Program Controlled by p53 and p16INK4a Contributes to the Outcome of Cancer Therapy

2002 • 1,009 citations

The INK4a/ARF network in tumour suppression

2001 • 956 citations

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

2004 • 945 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

Essential role for oncogenic Ras in tumour maintenance

1999 • 880 citations

Reversible Tumorigenesis by MYC in Hematopoietic Lineages

1999 • 871 citations

Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.

1991 • 861 citations

Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells

2001 • 854 citations

p53 and E2F-1 cooperate to mediate apoptosis.

1994 • 844 citations

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

1999 • 828 citations

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

2000 • 826 citations

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

2002 • 803 citations

Endogenous oncogenic K-rasG12D stimulates proliferation and widespread neoplastic and developmental defects

2004 • 780 citations

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

1994 • 747 citations

Tumor suppression by Ink4a–Arf: progress and puzzles

2003 • 700 citations

Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

2002 • 676 citations

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

1997 • 648 citations

Suppression of Myc-Induced Apoptosis in β Cells Exposes Multiple Oncogenic Properties of Myc and Triggers Carcinogenic Progression

2002 • 624 citations

E1A signaling to p53 involves the p19^ARFtumor suppressor

1998 • 614 citations

Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

2003 • 550 citations

Molecular mechanisms of "detachment-induced apoptosis--Anoikis".

2002 • 534 citations

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

2003 • 532 citations

PML is induced by oncogenicrasand promotes premature senescence

2000 • 519 citations

Dissecting p53 tumor suppressor functions in vivo

2002 • 491 citations

Hallmarks of senescence in carcinogenesis and cancer therapy

2004 • 489 citations

Bim is a suppressor of Myc-induced mouse B cell leukemia

2004 • 485 citations

On the shoulders of giants: p63, p73 and the rise of p53

2002 • 485 citations

Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F

1997 • 468 citations

Reversible Activation of c-Myc in Skin

1999 • 468 citations

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53

1999 • 455 citations

A Subset of Tumor-Derived Mutant Forms of p53 Down-Regulate p63 and p73 through a Direct Interaction with the p53 Core Domain

2001 • 454 citations

p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis

2003 • 432 citations

Control of the Replicative Life Span of Human Fibroblasts by p16 and the Polycomb Protein Bmi-1

2002 • 425 citations

Characterization of XIAP-Deficient Mice

2001 • 425 citations

Direct coupling of the cell cycle and cell death machinery by E2F

2002 • 419 citations

Chemosensitivity linked to p73 function

2003 • 404 citations

Regulation of a Senescence Checkpoint Response by the E2F1 Transcription Factor and p14^ARF Tumor Suppressor

2000 • 391 citations

A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis

1994 • 391 citations

Cellular senescence as a tumor-suppressor mechanism

2001 • 362 citations

Induction of ovarian cancer by defined multiple genetic changes in a mouse model system

2002 • 356 citations

Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis

2002 • 339 citations

Up-regulation of Bcl-2 Homology 3 (BH3)-only Proteins by E2F1 Mediates Apoptosis

2004 • 316 citations

Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation

2000 • 311 citations

Myc Requires Distinct E2F Activities to Induce S Phase and Apoptosis

2001 • 253 citations

Regulation of Bcl-xL: a little bit of this and a little bit of STAT

2000 • 235 citations

Identification of Positively and Negatively Acting Elements Regulating Expression of the E2F2 Gene in Response to Cell Growth Signals

1997 • 211 citations

Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation

2001 • 210 citations

Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation

2001 • 209 citations

Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis

2003 • 201 citations

Suppression of tumorigenesis by the p53 target PUMA

2004 • 178 citations

Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics

2004 • 174 citations

E2F1 and c-Myc in Cell Growth and Death

2003 • 169 citations

Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53

1998 • 159 citations

Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1

2001 • 159 citations

Homeostatic control of lymphocyte survival: potential origins and implications

2002 • 157 citations

The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo

2002 • 149 citations

Dual functions of E2F-1 in a transgenic mouse model of liver carcinogenesis

2000 • 148 citations

Arf tumor suppressor promoter monitors latent oncogenic signals in vivo

2003 • 148 citations

Direct repression of the Mcl-1 promoter by E2F1

2002 • 142 citations

Regulation of the cell cycle and apoptosis by the oncogenes of adenovirus

2001 • 135 citations

Apoptosis Associated with Deregulated E2F Activity Is Dependent on E2F1 and Atm/Nbs1/Chk2

2004 • 124 citations

Upstream Regulatory Role for XIAP in Receptor-Mediated Apoptosis

2004 • 115 citations

Normal Human Fibroblasts Are Resistant to RAS-Induced Senescence

2004 • 104 citations

Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion

2000 • 103 citations

Myc-Mediated Proliferation and Lymphomagenesis, but Not Apoptosis, Are Compromised by E2f1 Loss

2003 • 101 citations

Simultaneous modulation of multidrug resistance and antiapoptotic cellular defense by MDR1 and BCL-2 targeted antisense oligonucleotides enhances the anticancer efficacy of doxorubicin.

2003 • 100 citations

Repression of the Human Papillomavirus E6 Gene Initiates p53-Dependent, Telomerase-Independent Senescence and Apoptosis in HeLa Cervical Carcinoma Cells

2004 • 97 citations

The new kid on the block(ade) of the IGF-1 receptor

2004 • 95 citations

p19^ARF Is Dispensable for Oncogenic Stress-Induced p53-Mediated Apoptosis and Tumor Suppression In Vivo

2002 • 86 citations

CIAP1 and the serine protease HTRA2 are involved in a novel p53-dependent apoptosis pathway in mammals

2003 • 84 citations

p63 and p73 are not required for the development and p53-dependent apoptosis of T cells

2004 • 82 citations

p19 Arf Suppresses Growth, Progression, and Metastasis of Hras-Driven Carcinomas through p53-Dependent and -Independent Pathways

2004 • 80 citations

c-Myc Augments the Apoptotic Activity of Cytosolic Death Receptor Signaling Proteins by Engaging the Mitochondrial Apoptotic Pathway

2002 • 78 citations

ARF Differentially Modulates Apoptosis Induced by E2F1 and Myc

2002 • 70 citations

E1A Sensitizes Cells to Tumor Necrosis Factor Alpha by Downregulating c-FLIP_S

2003 • 66 citations

Novel cancer therapy by reactivation of the p53 apoptosis pathway

2003 • 53 citations

The ink4a/arf Tumor Suppressors Cooperate with p21 in the Processes of Mouse Epidermal Differentiation, Senescence, and Carcinogenesis

2001 • 53 citations

The DNA Damage Checkpoint in Embryonic Cell Cycles Is Dependent on the DNA-to-Cytoplasmic Ratio

2004 • 47 citations

Atm Is Dispensable for p53 Apoptosis and Tumor Suppression Triggered by Cell Cycle Dysfunction

1999 • 42 citations

p53 leans on its siblings

2002 • 39 citations