Secondary leukemias induced by topoisomerase-targeted drugs

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I

1995 • 3,492 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

Proposed Revised Criteria for the Classification of Acute Myeloid Leukemia

1985 • 2,981 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Growth Factors and Cancer

1991 • 2,044 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

DNA TOPOISOMERASES

1985 • 1,524 citations

The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants

1997 • 1,482 citations

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

1991 • 1,463 citations

REPAIR OF OXIDATIVE DAMAGE TO DNA: Enzymology and Biology

1994 • 1,435 citations

The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

1991 • 1,371 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP

1995 • 1,197 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Role of the histone deacetylase complex in acute promyelocytic leukaemia

1998 • 1,091 citations

Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia

1998 • 1,021 citations

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

1992 • 944 citations

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.

1991 • 897 citations

The Cellular Functions of Small GTP-Binding Proteins

1990 • 881 citations

UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells.

1984 • 874 citations

Altered Hox expression and segmental identity in Mll-mutant mice

1995 • 871 citations

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

1992 • 850 citations

Structure and mechanism of DNA topoisomerase II

1996 • 844 citations

The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB–binding protein

1996 • 756 citations

Acute Myeloid Leukemia in Children Treated with Epipodophyllotoxins for Acute Lymphoblastic Leukemia

1991 • 723 citations

DNA Topoisomerases: Essential Enzymes and Lethal Targets

1994 • 722 citations

Exposure of infants to phyto-oestrogens from soy-based infant formula

1997 • 715 citations

Molecular Analysis of Acute Promyelocytic Leukemia Breakpoint Cluster Region on Chromosome 17

1990 • 650 citations

Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt

1992 • 582 citations

An Mll–AF9 Fusion Gene Made by Homologous Recombination Causes Acute Leukemia in Chimeric Mice: A Method to Create Fusion Oncogenes

1996 • 534 citations

Retinoids in cancer therapy.

1992 • 505 citations

Leukemia Following Hodgkin's Disease

1990 • 502 citations

Topoisomerase Poisons: Harnessing the Dark Side of Enzyme Mechanism

1995 • 501 citations

Broad Thumbs and Toes and Facial Abnormalities

1963 • 501 citations

Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt

1992 • 494 citations

Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.

1984 • 491 citations

Acute promyelocytic leukemia: from genetics to treatment

1994 • 474 citations

Characterization of a Zinc Finger Gene Disrupted by the t(15;17) in Acute Promyelocytic Leukemia

1991 • 464 citations

Secondary Acute Myeloid Leukemia in Children Treated for Acute Lymphoid Leukemia

1989 • 457 citations

Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons.

1990 • 427 citations

Deletion of IRF-1 , Mapping to Chromosome 5q31.1, in Human Leukemia and Preleukemic Myelodysplasia

1993 • 392 citations

Acute promyelocytic leukemia: from genetics to treatment

1994 • 384 citations

Increased risk of myelodysplasia and leukaemia after etoposide, cisplatin, and bleomycin for germ-cell tumours

1991 • 373 citations

Acute leukemia with promyelocytic features in PML/RARα transgenic mice

1997 • 366 citations

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene

1997 • 362 citations

The balanced and the unbalanced chromosome aberrations of acute myeloid leukemia may develop in different ways and may contribute differently to malignant transformation

1994 • 361 citations

Leukemia After Therapy With Alkylating Agents for Childhood Cancer2

1987 • 356 citations

Involvement of ras p21 protein in signal-transduction pathways from interleukin 2, interleukin 3, and granulocyte/macrophage colony-stimulating factor, but not from interleukin 4.

1991 • 351 citations

AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia

1995 • 346 citations

Therapy-related acute myeloid leukemia and myelodysplastic syndrome: a clinical and morphologic study of 65 cases

1985 • 329 citations

MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)

1997 • 323 citations

Rearrangements of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA- topoisomerase II

1993 • 319 citations

Clinical characteristics and treatment outcome of childhood acute lymphoblastic leukemia with the t(4;11)(q21;q23): a collaborative study of 40 cases [see comments]

1991 • 307 citations

The capture of a DNA double helix by an ATP-dependent protein clamp: A key step in DNA transport by type II DNA topoisomerases

1992 • 303 citations

Increased risk for myelodysplastic syndromes in individuals with glutathione transferase theta 1 (GSTT1) gene defect

1996 • 301 citations

Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs.

1993 • 297 citations

Persistence of the 8;21 translocation in patients with acute myeloid leukemia type M2 in long-term remission

1993 • 297 citations

Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome

1993 • 294 citations

Homozygous Inactivation of theNF1Gene in Bone Marrow Cells from Children with Neurofibromatosis Type 1 and Malignant Myeloid Disorders

1997 • 292 citations

Mechanism of Action of Antitumor Drug Etoposide: A Review

1988 • 291 citations

Chromosome aberrations and prognostic factors in therapy-related myelodysplasia and acute nonlymphocytic leukemia

1990 • 288 citations

Leukemia Following Chemotherapy for Ovarian Cancer

1990 • 282 citations

p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.

1994 • 276 citations

Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations.

1994 • 272 citations

Secondary acute myeloid leukemia in children with acute lymphoblastic leukemia treated with etoposide.

1993 • 269 citations

Childhood monosomy 7: epidemiology, biology, and mechanistic implications

1995 • 269 citations

Adenoviral E1A-Associated Protein p300 Is Involved in Acute Myeloid Leukemia With t(11; 22)(q23; q13)

1997 • 264 citations

Use of a tourniquet to prolong the effect of penicillin.

1947 • 264 citations

Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation.

1993 • 260 citations

Defects in Yolk Sac Hematopoiesis in Mll-Null Embryos

1997 • 257 citations

Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor alpha locus.

1991 • 253 citations

p53 Protein Exhibits 3′-to-5′ Exonuclease Activity

1996 • 248 citations

Acute Nonlymphocytic Leukemia after Therapy with Alkylating Agents for Ovarian Cancer

1982 • 247 citations

Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23)

1997 • 247 citations

Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases.

1993 • 247 citations

Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: correlation with scaffold attachment regions and topoisomerase II consensus binding sites

1996 • 242 citations

The t(11;16)(q23;p13) Translocation in Myelodysplastic Syndrome Fuses the MLL Gene to the CBP Gene

1997 • 240 citations

The role of DNA topoisomerases in recombination and genome stability: A double-edged sword?

1990 • 236 citations

Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome

1993 • 236 citations

Acute nonlymphocytic leukemia following etoposide and cisplatin combination chemotherapy for advanced non-small-cell carcinoma of the lung

1987 • 233 citations

Biology and treatment of infant leukemias.

1995 • 231 citations

Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product.

1993 • 231 citations

Epipodophyllotoxins, alkylating agents, and radiation and risk of secondary leukaemia after childhood cancer.

1992 • 229 citations

Effect of antineoplastic agents on the DNA cleavage/religation reaction of eukaryotic topoisomerase II: inhibition of DNA religation by etoposide

1989 • 228 citations

Occupational exposures of parents of children with acute nonlymphocytic leukemia: a report from the Childrens Cancer Study Group.

1989 • 227 citations

p53-catalyzed annealing of complementary single-stranded nucleic acids.

1993 • 225 citations

Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia.

1994 • 223 citations

Maternal exposure to potential inhibitors of DNA topoisomerase II and infant leukemia (United States): A report from the Children's Cancer Group

1996 • 222 citations

Molecular pathogenesis of the chromosome 16 inversion in the M4Eo subtype of acute myeloid leukemia [see comments]

1995 • 220 citations

ALL-1 partial duplication in acute leukemia.

1994 • 219 citations

All Patients With the T(11; 16)(q23; p13.3) That Involves MLL and CBP Have Treatment-Related Hematologic Disorders

1997 • 219 citations

Germline p53 mutations are frequently detected in young children with rhabdomyosarcoma.

1995 • 217 citations

Secondary Leukemia Associated With a Conventional Dose of Etoposide: Review of Serial Germ Cell Tumor Protocols

1993 • 216 citations

AF6q21, a Novel Partner of the MLL Gene in t(6; 11)(q21; q23), Defines a Forkhead Transcriptional Factor Subfamily

1997 • 215 citations

Eukaryotic topoisomerase II. Characterization of enzyme turnover.

1986 • 213 citations

Parental Alcohol Consumption, Cigarette Smoking, and Risk of Infant Leukemia: a Childrens Cancer Group Study

1996 • 213 citations

Leukemia and Preleukemia after Adjuvant Treatment of Gastrointestinal Cancer with Semustine (Methyl-CCNU)

1983 • 211 citations

Balanced translocations involving chromosome bands 11q23 and 21q22 are highly characteristic of myelodysplasia and leukemia following therapy with cytostatic agents targeting at DNA-topoisomerase II [letter]

1991 • 210 citations

Risk of Acute Nonlymphocytic Leukemia and Preleukemia in Patients Treated with Cyclophosphamide for Non-Hodgkin's Lymphomas

1985 • 210 citations

Leukemia in breast cancer patients following adjuvant chemotherapy or postoperative radiation: the NSABP experience.

1985 • 207 citations

Acute nonlymphocytic leukemia following etoposide and cisplatin combination chemotherapy for advanced non-small-cell carcinoma of the lung

1987 • 204 citations

When good enzymes go bad: Conversion of topoisomerase II to a cellular toxin by antineoplastic drugs

1993 • 203 citations

Second malignant neoplasms complicating Hodgkin's disease: the National Cancer Institute experience.

1984 • 196 citations

Secondary acute myeloid leukemia in children previously treated with alkylating agents, intercalating topoisomerase II inhibitors, and irradiation.

1993 • 193 citations

Detection of DNA rearrangements in the AML1 and ETO loci and of an AML1/ETO fusion mRNA in patients with t(8;21) acute myeloid leukemia

1993 • 193 citations

Maternal drug use and risk of childhood nonlymphoblastic leukemia among offspring. An epidemiologic investigation implicating marijuana (a report from the childrens cancer study group)

1989 • 189 citations

Single- and double-strand DNA breakage and repair in human lung adenocarcinoma cells exposed to etoposide and teniposide.

1985 • 187 citations

Variability in human cytochrome P450 paclitaxel metabolism.

1995 • 186 citations

Therapy‐related acute myeloid leukemia following treatment with epipodophyllotoxins: Estimating the risks

1994 • 182 citations

The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1.

1993 • 179 citations

Therapy-related acute myeloid leukemia with t(8;21), inv(16), and t(8;16): a report on 25 cases and review of the literature.

1993 • 178 citations

Epipodophyllotoxin-related leukemia. Identification of a new subset of secondary leukemia

1991 • 178 citations

Melphalan May Be a More Potent Leukemogen than Cyclophosphamide

1986 • 177 citations

Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation.

1993 • 174 citations

DNA topoisomerase I and II in cancer chemotherapy: update and perspectives

1993 • 174 citations

Topoisomerase Inhibitors

1995 • 173 citations

The Secondary Leukemias: Challenges and Research Directions

1996 • 172 citations

Site-specific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase II inhibitors [see comments]

1996 • 171 citations

A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia

1995 • 169 citations

Second malignant neoplasms following childhood Hodgkin's disease: Treatment and splenectomy as risk factors

1989 • 167 citations

ALL-1 tandem duplication in acute myeloid leukemia with a normal karyotype involves homologous recombination between Alu elements.

1994 • 167 citations

HRX involvement in de novo and secondary leukemias with diverse chromosome 11q23 abnormalities [see comments]

1993 • 166 citations

Second malignancies after treatment of Hodgkin's disease: the influence of treatment, follow-up time, and age.

1993 • 165 citations

Stem Cell Transplantation for Secondary Acute Myeloid Leukemia: Evaluation of Transplantation as Initial Therapy or Following Induction Chemotherapy

1997 • 161 citations

Cytogenetic studies in patients with secondary leukemia/dysmyelopoietic syndrome after different treatment modalities

1988 • 159 citations

Persistence of the AML1/ETO fusion transcript in patients treated with allogeneic bone marrow transplantation for t(8;21) leukemia

1996 • 157 citations

Cloning and characterization of the t(X;II) breakpoint from a leukemic cell line identify a new member of the forkhead gene family

1994 • 155 citations

Secondary neoplasms following treatment of malignant germ cell tumors.

1993 • 150 citations

Sequence analysis of the breakpoint cluster region in the ALL-1 gene involved in acute leukemia.

1994 • 149 citations

Leukemia or Lymphoma and Coexistent Primary Malignant Lesions: A Review of the Literature and a Study of 120 Cases

1957 • 149 citations

Junctions of the AML1/MTG8(ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction

1993 • 139 citations

Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases.

1993 • 139 citations

The t(10;11) translocation in acute myeloid leukemia (M5) consistently fuses the leucine zipper motif of AF10 onto the HRX gene

1995 • 138 citations

ALL-1 gene rearrangements in DNA topoisomerase II inhibitor-related leukemia in children

1995 • 137 citations

Signal transduction through small GTPases—A tale of two GAPs

1992 • 137 citations

Synergistic up-regulation of the myeloid-specific promoter for the macrophage colony-stimulating factor receptor by AML1 and the t(8;21) fusion protein may contribute to leukemogenesis.

1996 • 137 citations

Epipodophyllotoxin-related acute myeloid leukemia: a study of 35 cases.

1995 • 136 citations

A novel gene, AF1q, fused to MLL in t(1;11) (q21;q23), is specifically expressed in leukemic and immature hematopoietic cells

1995 • 136 citations

Acute monocytic or myelomonocytic leukemia with balanced chromosome translocations to band 11q23 after therapy with 4-epi-doxorubicin and cisplatin or cyclophosphamide for breast cancer.

1992 • 133 citations

Therapy of Secondary Acute Nonlymphocytic Leukemia with Cytarabine

1983 • 133 citations

ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells

1994 • 132 citations

EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia

1997 • 125 citations

Intensive chemotherapy for poor prognosis myelodysplasia (MDS) and secondary acute myeloid leukemia (sAML) following MDS of more than 6 months duration. A pilot study by the Leukemia Cooperative Group of the European Organisation for Research and Treatment in Cancer (EORTC-LCG).

1995 • 125 citations

Local base sequence preferences for DNA cleavage by mammalian topoisomerase II in the presence of amsacrine or teniposide

1991 • 124 citations

Double-stranded DNA cleavage/religation reaction of eukaryotic topoisomerase II: evidence for a nicked DNA intermediate

1989 • 124 citations

Proteolysis patterns of epitopically labeled yeast DNA topoisomerase II suggest an allosteric transition in the enzyme induced by ATP binding.

1991 • 124 citations

Spontaneous DNA Lesions Poison Human Topoisomerase IIα and Stimulate Cleavage Proximal to Leukemic 11q23 Chromosomal Breakpoints

1997 • 119 citations

Mutagenic responses of thirteen anticancer drugs on mutation induction at multiple genetic loci and on sister chromatid exchanges in Chinese hamster ovary cells.

1983 • 117 citations

LCH‐I: A randomized trial of etoposide vs. vinblastine in disseminated langerhans cell histiocytosis

1994 • 117 citations

Involvement of the AML1 gene in the t(3;21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis

1993 • 116 citations

ALL-1 gene at chromosome 11q23 is consistently altered in acute leukemia of early infancy

1993 • 115 citations

Acute Nonlymphocytic Leukemia in Germ Cell Tumor Patients Treated With Etoposide-Containing Chemotherapy

1993 • 114 citations

A novel gene, AF-1p, fused to HRX in t(1;11)(p32;q23), is not related to AF-4, AF-9 nor ENL.

1994 • 111 citations

The Causes and Consequences of Chromosomal Aberrations

1992 • 110 citations

Topoisomerase II-mediated DNA breaks and cytotoxicity in relation to cell proliferation and the cell cycle in NIH 3T3 fibroblasts and L1210 leukemia cells.

1987 • 109 citations

The (4;11)(q21;q23) chromosome translocations in acute leukemias involve the VDJ recombinase.

1992 • 109 citations

Therapy-related acute promyelocytic leukemia: a report on 16 cases.

1992 • 108 citations

Detection of ALL-1/AF4 fusion transcript by reverse transcription- polymerase chain reaction for diagnosis and monitoring of acute leukemias with the t(4;11) translocation

1993 • 108 citations

Myeloid neoplasia in children treated for solid tumours

1990 • 108 citations

Chromosome band 11q23 translocation breakpoints are DNA topoisomerase II cleavage sites.

1995 • 107 citations

Heterogeneity in CBF beta/MYH11 fusion messages encoded by the inv(16)(p13q22) and the t(16;16)(p13;q22) in acute myelogenous leukemia

1995 • 106 citations

Abasic Sites Stimulate Double-stranded DNA Cleavage Mediated by Topoisomerase II

1995 • 105 citations

Cigarette smoking and alcohol consumption by parents of children with acute myeloid leukemia: an analysis within morphological subgroups--a report from the Childrens Cancer Group.

1993 • 102 citations

Potential topoisomerase II DNA-binding sites at the breakpoints of a t(9;11) chromosome translocation in acute myeloid leukemia.

1993 • 101 citations

Histidine 289 Is Essential for Hydrolysis of the Alkyl-enzyme Intermediate of Haloalkane Dehalogenase

1995 • 101 citations

Apurinic Sites Are Position-specific Topoisomerase II Poisons

1997 • 99 citations

A reverse transcriptase-polymerase chain reaction detects heterogeneous chimeric mRNAs in leukemias with 11q23 abnormalities

1994 • 97 citations

Acute non-lymphocytic leukemia in patients with ovarian carcinoma following long-term treatment with treosulfan (=dihydroxybusulfan)

1980 • 95 citations

Sequence specific generation of a DNA panhardle permits PCR amplication of unknown flanking DNA

1992 • 95 citations

ALL-1 gene at chromosome 11q23 is consistently altered in acute leukemia of early infancy

1993 • 95 citations

The ETO portion of acute myeloid leukemia t(8;21) fusion transcript encodes a highly evolutionarily conserved, putative transcription factor.

1994 • 94 citations

Therapy-Related Acute Nonlymphocytic Leukemia with Monocytic Features and Rearrangement of Chromosome 11q

1989 • 93 citations

Monosomy 7 myelodysplastic syndrome and other second malignant neoplasms in children with neurofibromatosis type 1.

1997 • 91 citations

Bone marrow transplantation for myelodysplasia and secondary acute nonlymphoblastic leukemia.

1990 • 90 citations

The topoisomerase II inhibitor VM-26 induces marked changes in histone H1 kinase activity, histones H1 and H3 phosphorylation, and chromosome condensation in G2 phase and mitotic BHK cells.

1990 • 90 citations

Cell death induced by topoisomerase inhibitors

1991 • 89 citations

Etoposide (VP-16-213)-induced gene alterations: potential contribution to cell death.

1991 • 85 citations

Gene Amplification in a p53-Deficient Cell Line Requires Cell Cycle Progression under Conditions That Generate DNA Breakage

1998 • 85 citations

Characterization of a fusion cDNA (RARA/myl) transcribed from the t(15;17) translocation breakpoint in acute promyelocytic leukemia.

1992 • 84 citations

Acute leukemia in association with langerhans cell histiocytosis

1994 • 84 citations

The der(11)-encoded MLL/AF-4 fusion transcript is consistently detected in t(4;11)(q21;q23)-containing acute lymphoblastic leukemia

1994 • 84 citations

Low risk of secondary leukemias after chemotherapy without mechlorethamine in childhood Hodgkin's disease. German-Austrian Pediatric Hodgkin's Disease Group.

1997 • 83 citations

The p53 gene in pediatric therapy-related leukemia and myelodysplasia

1996 • 82 citations

L-asparaginase may potentiate the leukemogenic effect of the epipodophyllotoxins.

1995 • 82 citations

Increased incidence of acute nonlymphocytic leukemia following therapy in patients with small cell carcinoma of the lung.

1984 • 80 citations

p53 gene mutations in pediatric brain tumors

1995 • 78 citations

Monosomy 7 myelodysplastic syndrome and other second malignant neoplasms in children with neurofibromatosis type 1

1997 • 78 citations

Acute myeloid leukemia in patients treated for rhabdomyosarcoma with cyclophosphamide and low‐dose etoposide on intergroup rhabdomyosarcoma study III: An interim report

1994 • 76 citations

Splenectomy and the increasing risk of secondary acute leukemia in Hodgkin's disease.

1993 • 75 citations

The association of specific “favorable” cytogenetic abnormalities with secondary leukemia

1986 • 74 citations

Molecular analysis of infant acute lymphoblastic leukemia: MLL gene rearrangement and reverse transcriptase-polymerase chain reaction for t(4; 11)(q21; q23)

1995 • 74 citations

Human cytochrome P450 metabolism of teniposide and etoposide.

1992 • 74 citations

Acute nonlymphocytic leukemia, preleukemia, and solid tumors following intensive chemotherapy of small cell carcinoma of the lung

1985 • 74 citations

Chromosome aberrations induced by etoposide (VP‐16) are not random

1990 • 73 citations

Disruption of a topoisomerase-DNA cleavage complex by a DNA helicase.

1994 • 73 citations

Mechanism of epipodophyllotoxin-induced cell death in poly(adenosine diphosphate-ribose) synthesis-deficient V79 Chinese hamster cell lines.

1990 • 73 citations

Topoisomerase II inhibitors induce DNA double-strand breaks at a specific site within the AML1 locus

1997 • 73 citations

Double knockout of the ALL-1 gene blocks hematopoietic differentiation in vitro.

1996 • 71 citations

The 8;21 chromosome translocation in acute myeloid leukemia is always detectable by molecular analysis using AML1

1993 • 71 citations

Consistent disruption of the AML1 gene occurs within a single intron in the t(8;21) chromosomal translocation.

1992 • 70 citations

Secondary acute myelogenous leukemia following safe exposure to etoposide.

1997 • 69 citations

Specific chromosomal translocations and therapy related leukemia induced by bimolane therapy for psoriasis

1992 • 68 citations

Complete exon structure of the ALL1 gene.

1996 • 68 citations

Radiotherapy- and chemotherapy-induced myelodysplasia and acute myeloid leukemia. A review

1992 • 68 citations

RT-PCR diagnosis of patients with acute nonlymphocytic leukemia and inv(16)(p13q22) and identification of new alternative splicing in CBFB- MYH11 transcripts

1995 • 67 citations

Chemotherapy-related – and late occurring – Philadelphia chromosome in AML, ALL and CML. Similar events related to treatment with DNA topoisomerase II inhibitors?

1997 • 67 citations

Panhandle PCR strategy to amplify MLL genomic breakpoints in treatment-related leukemias

1997 • 67 citations

Implication of prior treatment with drug combinations including inhibitors of topoisomerase II in therapy‐related monocytic leukemia with a 9;11 translocation

1990 • 63 citations

Frequent Jumping Translocations of Chromosomal Segments Involving the ABL Oncogene Alone or in Combination With CD3-MLL Genes in Secondary Leukemias

1997 • 63 citations

Busulfan/cyclophosphamide as conditioning regimen for allogeneic bone marrow transplantation for myelodysplasia.

1995 • 62 citations

Study of allosteric communication between protomers by immunotagging

1993 • 59 citations

Spontaneous DNA Damage Stimulates Topoisomerase II-mediated DNA Cleavage

1997 • 59 citations

Changing patterns of care in the management of anemia.

1992 • 57 citations

Chromosome pattern in juvenile chronic myelogenous leukemia, myelodysplastic syndrome, and acute leukemia associated with neurofibromatosis.

1989 • 57 citations

Protein kinase C modulates the catalytic activity of topoisomerase II by enhancing the rate of ATP hydrolysis: evidence for a common mechanism of regulation by phosphorylation

1993 • 56 citations

Small Deletion and Insertion Mutations Induced by the Topoisomerase II Inhibitor Teniposide in CHO Cells and Comparison with Sites of Drug-stimulated DNA Cleavage in Vitro

1993 • 54 citations

Treatment of children with epipodophyllotoxin-induced secondary acute myeloid leukemia

1997 • 53 citations

Acute lymphoblastic leukaemia with t(4; 11) follows neuroblastoma: A late effect of treatment?

1985 • 52 citations

Favorable cytogenetic abnormalities in secondary leukemia

1989 • 51 citations

Report of the Cancer Therapy Evaluation Program Monitoring Plan for Secondary Acute Myeloid Leukemia Following Treatment With Epipodophyllotoxins

1993 • 51 citations

Abnormalities in the long arm of chromosome 11 (11q) in patients with de novo and secondary acute myelogenous leukemias and myelodysplastic syndromes.

1994 • 51 citations

Translocation (9;11)(p21;q23) in a child with acute monoblastic leukemia following 2 1/2 years after successful chemotherapy for neuroblastoma.

1986 • 50 citations

Effect of casein kinase II-mediated phosphorylation on the catalytic cycle of topoisomerase II. Regulation of enzyme activity by enhancement of ATP hydrolysis.

1992 • 47 citations

Common region of ALL-1 gene disrupted in epipodophyllotoxin-related secondary acute myeloid leukemia.

1993 • 46 citations

Detection of 11q23/MLL rearrangements in infant leukemias with fluorescence in situ hybridization and molecular analysis.

1995 • 44 citations

Relationship Between Cytotoxicity and Site-Specific DNA Recombination After In Vitro Exposure of Leukemia Cells to Etoposide

1996 • 43 citations

TOPOISOMERASES IN HUMAN DISEASE

1988 • 40 citations

Intensive chemotherapy with idarubicin, cytosine arabinoside, and granulocyte colony-stimulating factor (G-CSF) in patients with secondary and therapy-related acute myelogenous leukemia

1997 • 39 citations

RAS mutations in pediatric leukemias withMLL gene rearrangements

1998 • 39 citations

Sequential development of Wilms tumor, T-cell acute lymphoblastic leukemia, medulloblastoma and myeloid leukemia in a child with type 1 neurofibromatosis: a clinical and cytogenetic case report.

1993 • 39 citations

Intensive Alternating Drug Pairs After Remission Induction for Treatment of Infants With Acute Lymphoblastic Leukemia

1998 • 38 citations

Panhandle Polymerase Chain Reaction Amplifies MLL Genomic Translocation Breakpoint Involving Unknown Partner Gene

1997 • 36 citations

Translocation breakpoints are clustered on both chromosome 8 and chromosome 21 in the t(8;21) of acute myeloid leukemia

1993 • 35 citations

Integration of Simian Virus 40 into Cellular DNA Occurs at or near Topoisomerase II Cleavage Hot Spots Induced by VM-26 (Teniposide)

1993 • 33 citations

YeastSaccharomyces cerevisiae as a model system to study the cytotoxic activity of the antitumor drug camptothecin

1994 • 31 citations

Role of the semi-quinone free radical of the anti-tumour agent etoposide (VP-16-213) in the inactivation of single- and double-stranded ΦX174 DNA

1990 • 31 citations

Two distinct loci on the short arm of chromosome 16 are involved in myeloid leukemia

1991 • 30 citations

Acute nonlymphocytic leukemia after treatment of small cell lung cancer

1986 • 29 citations

Potential role for wild-type p53 in leukemias with MLL gene translocations

1998 • 26 citations

Clinical pharmacokinetics and pharmacodynamics of epipodophyllotoxins.

1993 • 25 citations

Differences in teniposide disposition and pharmacodynamics in patients with newly diagnosed and relapsed acute lymphocytic leukemia.

1992 • 24 citations

Integration of simian virus 40 into cellular DNA occurs at or near topoisomerase II cleavage hot spots induced by VM-26 (teniposide).

1993 • 24 citations

Specific chromosome changes and non-occupational exposure to potentially carcinogenic agents in acute leukemia in china

1989 • 23 citations

Human trithorax gene rearrangements in therapy-related acute leukaemia after etoposide treatment.

1994 • 21 citations

Characterization of tumor cell resistance to 4'-deoxy-4'-iododoxorubicin developed in Ehrlich ascites cells in vivo.

1992 • 18 citations

Cytogenetic effects of etoposide (VP-16) on human lymphocytes; with special reference to the relation between sister chromatid exchange and chromatid breakage.

1986 • 17 citations

Acute Leukemia after Successful Chemotherapy for Oat Cell Carcinoma

1983 • 16 citations

A method for the amplification of unknown flanking DNA: targeted inverted repeat amplification.

1993 • 15 citations

Acute promyelocytic leukemia following treatment of non‐Hodgkin's lymphoma

1989 • 14 citations

Causes of Childhood Leukemia Beginning To Emerge

1998 • 14 citations

Secondary pre-leukaemia and etoposide

1991 • 14 citations

Acute nonlymphoblastic leukemia in children treated for acute lymphoblastic leukemia with an intensive regimen including teniposide

1992 • 12 citations

Acute promyelocytic leukemia following treatment of non-Hodgkin's lymphoma

1989 • 11 citations

Panhandle PCR.

1995 • 7 citations