Effect of antineoplastic agents on the DNA cleavage/religation reaction of eukaryotic topoisomerase II: inhibition of DNA religation by etoposide

Construction and characterization of new cloning vehicles. II. A multipurpose cloning system. 1977.

1992 • 4,683 citations

Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.

1984 • 896 citations

Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide.

1984 • 559 citations

Cleavage of DNA by mammalian DNA topoisomerase II.

1983 • 539 citations

Role of topoisomerase II in mediating epipodophyllotoxin-induced DNA cleavage.

1984 • 463 citations

DNA Topoisomerases: Enzymes That Control DNA Conformation

1985 • 337 citations

DNA topoisomerase II from Drosophila melanogaster. Relaxation of supercoiled DNA.

1983 • 302 citations

ATP-dependent DNA topoisomerase from D. melanogaster reversibly catenates duplex DNA rings

1980 • 292 citations

Double strand DNA cleavage by type II DNA topoisomerase from Drosophila melanogaster.

1983 • 284 citations

Biochemical basis for the interactions of type I and type II topoisomerases with DNA

1989 • 251 citations

The podophyllotoxin derivatives VP16-213 and VM26

1982 • 146 citations

DNA topoisomerase II from Drosophila melanogaster. Purification and physical characterization.

1983 • 145 citations

DNA topoisomerase II: A primer on the enzyme and its unique role as a multidrug target in cancer chemotherapy

1987 • 139 citations

Formation and rejoining of deoxyribonucleic acid double-strand breaks induced in isolated cell nuclei by antineoplastic intercalating agents

1984 • 139 citations

Identification of DNA topoisomerase II as an intracellular target of antitumor epipodophyllotoxins in simian virus 40-infected monkey cells.

1985 • 136 citations

Calcium-promoted DNA cleavage by eukaryotic topoisomerase II: trapping the covalent enzyme-DNA complex in an active form

1987 • 134 citations

Effects of DNA intercalating agents on topoisomerase II induced DNA strand cleavage in isolated mammalian cell nuclei

1985 • 127 citations

DNA binding by epipodophyllotoxins and N-acyl anthracyclines: implications for mechanism of topoisomerase II inhibition.

1988 • 100 citations

DNA topoisomerase II as a target of antineoplastic drug therapy

1985 • 83 citations

Topoisomerases as Novel Targets for Cancer Chemotherapy

1988 • 46 citations